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Delta sleep-inducing peptide (DSIP) / Studies
Natural peptide · 9 amino acids · 848.8 Da

Delta sleep-inducing peptide (DSIP) studies and research data

PepBank has 371 DSIP studies with results. 246 of them gave DSIP, with 877 results, grouped by what the studies measured. In each group, results from studies in people come first. Data as of 2026-10-30.

Searches 877 results and 462 papers. Newer studies from Europe PMC

Results in people
113
13% of 877 results
Results in animals
650
74% of 877 results
Results in lab cells
114
13% of 877 results
From computer models
0
0% of 877 results
The molecule

DSIP identity

Identifiers, parent molecule, targets and development stage, from curated data.

Delta sleep-inducing peptide (INN emideltide) is the nonapeptide H-Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu-OH. It was first found in rabbit cerebral venous blood (Monnier, 1963) and characterized in 1977 (Schoenenberger and Monnier). FDA's 2026 briefing states that its primary mechanisms of action are unknown and that it is not a registered drug in any country FDA searched (GlobalEdge). That search missed Russia: Deltaran (lyophilisate for intranasal use, 0.3 mg synthetic DSIP with 3.0 mg glycine per ampoule) is a registered medicine there (Vidal and RLS listings). No precursor gene is identified in the sources checked.

Kind
Natural peptide · 9 residues
Identifiers
ChEMBLCHEMBL2104403 (opens in a new tab)PubChem CID68816 (opens in a new tab)UNIIYN28Z5YZ73 (opens in a new tab)CAS62568-57-4
Development
Approved in Russia only (registered as Deltaran / Дельтаран)Deltaran (DSIP + glycine): registration holder Scientific Research Center KOMKON LLC (Russia); manufacturer 'Gos.NII OChB FMBA' (Russia), per Vidal. FDA's briefing, citing Popovich et al. 2003, says Deltaran was designed at the Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences. No developer of the bare peptide identified.Registered in Russia only as far as checked (Deltaran, Vidal and RLS listings); registrations in other countries were not checked. No FDA or EMA approval. ChEMBL max_phase is 2.0 but ChEMBL shows no indication rows, so the basis is not visible. No studies on ClinicalTrials.gov (queries for emideltide, DSIP, Deltaran with synonym expansion off, 2026-10-09). FDA's briefing reviews small human studies from 1981 onward (insomnia, narcolepsy, opioid withdrawal). First found in rabbit blood by Monnier (1963, per FDA); characterized by Schoenenberger and Monnier 1977 (PMID 265572). Source (opens in a new tab)

Targets

No molecular target is recorded for this peptide.

Sequence and structure

Residues, differences from the parent, calculated properties and 3D structure. Source values and calculated values are shown separately.

Sequence

9 amino acids

H-
Residues 1 to 9:
WAGGDASGE
-OH
  • HydrophobicA V I L M
  • AromaticF W Y
  • NegativeD E
  • PolarS T N Q
  • SpecialC G P

Properties

From identity sources

Formula
C35H48N10O15
Molecular weight
848.8 g/mol
Monoisotopic mass
848.3301 Da

Calculated from the sequence

Average mass
848.82 Da
Sum of ExPASy residue masses + water · ExPASy Compute pI/Mw; FindMod
Monoisotopic mass
848.3300 Da
Sum of ExPASy residue masses + water · ExPASy FindMod
Isoelectric point (pI)
3.55
pH of zero net charge, EMBOSS pKa set · EMBOSS iep, Epk.dat
Net charge at pH 7.4
−2.06
Henderson-Hasselbalch, EMBOSS pKa set · EMBOSS iep, Epk.dat
GRAVY (hydropathy)
−0.700
Mean Kyte-Doolittle hydropathy · Kyte and Doolittle 1982
Negative: hydrophilic on average.
Extinction coefficient, 280 nm (Cys reduced)
5,500 M⁻¹ cm⁻¹
5500 x Trp + 1490 x Tyr · Pace et al. 1995 (ExPASy ProtParam)
Instability index
−2.48
Dipeptide instability weights (DIWV) · Guruprasad et al. 1990
40 or below: classed as stable (ExPASy).
Aliphatic index
22.2
Mole % A + 2.9 V + 3.9 (I + L) · Ikai 1980
Boman index
1.13 kcal/mol
Mean solubility value (negated) · Boman 2003
2.48 or below: lower protein-binding potential (Boman).
Hydrophobic moment (μH)
Not calculated
The sequence is too short for this method.
pI with each pKa set
EMBOSS 3.55Bjellqvist (ExPASy) 4.09IPC peptide 3.05IPC protein 3.29
  • Defined and validated for proteins; use with care for short peptides.
  • Assumes an ideal alpha helix. Many short peptides are not helical.

@pepdb/chem 0.2.0 · EMBOSS pKa set · ExPASy residue masses

Net charge by pH

pI 3.55 · Net charge at pH 7.4: −2.06

Point or use arrow keys

Net charge of Delta sleep-inducing peptide (DSIP) from pH 0 to 14 (EMBOSS pKa set). Isoelectric point 3.55. Net charge at pH 7.4: -2.06.−3−2−10+102468101214pHNet chargepH 7.4pI 3.55

Henderson-Hasselbalch, EMBOSS pKa set. Calculated, not measured.

Show as table
pHNet charge
01.00
11.00
20.96
30.61
4−0.72
5−1.78
6−1.98
7−2.02
8−2.20
9−2.72
10−2.96
11−3.00
12−3.00
13−3.00
14−3.00

Composition

  • Hydrophobic22% (2)
  • Aromatic11% (1)
  • Negative22% (2)
  • Polar11% (1)
  • Special33% (3)

9 residues. Each residue counts in one class; F and W count as aromatic.

A Ala2 · 22%
I Ile0 · 0%
L Leu0 · 0%
M Met0 · 0%
V Val0 · 0%
F Phe0 · 0%
W Trp1 · 11%
Y Tyr0 · 0%
H His0 · 0%
K Lys0 · 0%
R Arg0 · 0%
D Asp1 · 11%
E Glu1 · 11%
N Asn0 · 0%
Q Gln0 · 0%
S Ser1 · 11%
T Thr0 · 0%
C Cys0 · 0%
G Gly3 · 33%
P Pro0 · 0%

3D structure

No 3D structure

No experimental structure (PDB) and no UniProt entry for an AlphaFold model are listed for this peptide. Synthetic peptides often have neither. The sequence view above is the reference.

2D structure

Draws the structure in your browser with RDKit (about 2.3 MB, loaded once).

SMILES fromPubChem CID 68816(opens in a new tab)

C[C@@H](C(=O)NCC(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)O)NC(=O)[C@H](CC1=CNC2=CC=CC=C21)N
Results by area

What the studies measured

People first in each area, then animals, then lab cells. Counts are exact and come from studies that gave the peptide.

Trials and papers
Status and safety
Data