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Study · Non-randomized trial · n = 6 · 1981

7 results

Acute and delayed effects of DSIP (delta sleep-inducing peptide) on human sleep behavior.

Schneider-Helmert D, Gnirss F, Monnier M, Schenker J, Schoenenberger GA

International journal of clinical pharmacology, therapy, and toxicology1 Aug 1981Cited by 14 (Europe PMC)

PMID6895513 (opens in a new tab)PepBankPUB-06895513
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. 7 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In six healthy volunteers, DSIP infusion increased median total sleep time by 59% within 130 min compared with placebo.

    In plain wordsIn six healthy adults, DSIP increased sleep time by 59% in the next 130 minutes compared with placebo.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseTotal sleep time within 130 min after treatment
    Study

    n = 6

    Comparator
    Placebo
    Outcome group
    Sleep · Sleep
    Studied dose
    25 nmol/kg · intravenousAs given in this study (human).

    Measurements

    Increase in median total sleep time
    59%
    within 130 min vs placebo

    Source sentences

    Summary
    sleep increased by 59% (median of total sleep time) within a 130-min interval after the treatment as compared with placebo.
    2 context sentences
    Summary · context
    DSIP was applied as slow intravenous infusions at a dosage of 25 nmol/kg in the morning.
    Summary · context
    A first study of DSIP (= synthetic delta sleep-inducing peptide) application to humans was carried out in six normal volunteers (four males and two females) under extensive psychophysiologic observations and measurements in a double-blind cross-over design.
  2. 02HumanNon-randomized trialEfficacy outcome

    In six healthy volunteers, subjects reported a feeling of sleep pressure immediately after the DSIP infusion.

    In plain wordsIn six healthy adults, people felt a sense of sleep pressure right after DSIP.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseReported sleep pressure
    Study

    n = 6

    Outcome group
    Sleep · Sleep
    Studied dose
    25 nmol/kg · intravenousAs given in this study (human).

    Source sentences

    Summary
    The subjects immediately reported a feeling of sleep pressure, and sleep increased by 59% (median of total sleep time) within a 130-min interval after the treatment as compared with placebo.
    2 context sentences
    Summary · context
    DSIP was applied as slow intravenous infusions at a dosage of 25 nmol/kg in the morning.
    Summary · context
    A first study of DSIP (= synthetic delta sleep-inducing peptide) application to humans was carried out in six normal volunteers (four males and two females) under extensive psychophysiologic observations and measurements in a double-blind cross-over design.
  3. 03HumanNon-randomized trialEfficacy outcome

    In six healthy volunteers, DSIP shortened sleep onset on the following night.

    In plain wordsIn six healthy adults, DSIP was followed by quicker sleep onset the next night.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseSleep onset latency on the following night
    Study

    n = 6

    Outcome group
    Sleep · Sleep
    Studied dose
    25 nmol/kg · intravenousAs given in this study (human).

    Source sentences

    Summary
    shorter sleep onset
    2 context sentences
    Summary · context
    DSIP was applied as slow intravenous infusions at a dosage of 25 nmol/kg in the morning.
    Summary · context
    A first study of DSIP (= synthetic delta sleep-inducing peptide) application to humans was carried out in six normal volunteers (four males and two females) under extensive psychophysiologic observations and measurements in a double-blind cross-over design.
  4. 04HumanNon-randomized trialEfficacy outcome

    In six healthy volunteers, DSIP reduced the percentage of stage 1 sleep on the following night.

    In plain wordsIn six healthy adults, DSIP was followed by less light stage 1 sleep the next night.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreasePercentage of stage 1 sleep on the following night
    Study

    n = 6

    Outcome group
    Sleep · Sleep
    Studied dose
    25 nmol/kg · intravenousAs given in this study (human).

    Source sentences

    Summary
    reduced percentage of stage 1
    2 context sentences
    Summary · context
    DSIP was applied as slow intravenous infusions at a dosage of 25 nmol/kg in the morning.
    Summary · context
    A first study of DSIP (= synthetic delta sleep-inducing peptide) application to humans was carried out in six normal volunteers (four males and two females) under extensive psychophysiologic observations and measurements in a double-blind cross-over design.
  5. 05HumanNon-randomized trialEfficacy outcome

    In six healthy volunteers, DSIP improved sleep efficiency on the following night.

    In plain wordsIn six healthy adults, DSIP was followed by better sleep efficiency the next night.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseSleep efficiency on the following night
    Study

    n = 6

    Outcome group
    Sleep · Sleep
    Studied dose
    25 nmol/kg · intravenousAs given in this study (human).

    Source sentences

    Summary
    better sleep efficiency
    2 context sentences
    Summary · context
    DSIP was applied as slow intravenous infusions at a dosage of 25 nmol/kg in the morning.
    Summary · context
    A first study of DSIP (= synthetic delta sleep-inducing peptide) application to humans was carried out in six normal volunteers (four males and two females) under extensive psychophysiologic observations and measurements in a double-blind cross-over design.
  6. 06HumanNon-randomized trialSafety outcome

    In six healthy volunteers, behavioral and EEG analyses showed no sedation in the classic pharmacologic way after DSIP.

    In plain wordsIn six healthy adults, DSIP did not cause classic sedation on behavioral and brain-wave tests.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeSedation (behavioral and EEG analyses)
    Study

    n = 6

    Outcome group
    Adverse events · Sleep
    Studied dose
    25 nmol/kg · intravenousAs given in this study (human).

    Source sentences

    Summary
    sophisticated behavioral and EEG analyses revealed no sedation in the classic pharmacologic way.
    2 context sentences
    Summary · context
    DSIP was applied as slow intravenous infusions at a dosage of 25 nmol/kg in the morning.
    Summary · context
    A first study of DSIP (= synthetic delta sleep-inducing peptide) application to humans was carried out in six normal volunteers (four males and two females) under extensive psychophysiologic observations and measurements in a double-blind cross-over design.
  7. 07HumanNon-randomized trialSafety outcome

    In six healthy volunteers, DSIP was well tolerated, with no psychologic, physiologic or biochemical side effects observed.

    In plain wordsIn six healthy adults, DSIP was well tolerated and no side effects were seen.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeSide effects (psychologic, physiologic, biochemical)
    Study

    n = 6

    Outcome group
    Adverse events · Whole body
    Studied dose
    25 nmol/kg · intravenousAs given in this study (human).

    Source sentences

    Summary
    The compound was well-tolerated and no psychologic, physiologic, or biochemical side effects were observed.
    2 context sentences
    Summary · context
    DSIP was applied as slow intravenous infusions at a dosage of 25 nmol/kg in the morning.
    Summary · context
    A first study of DSIP (= synthetic delta sleep-inducing peptide) application to humans was carried out in six normal volunteers (four males and two females) under extensive psychophysiologic observations and measurements in a double-blind cross-over design.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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