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Study · Animal study (in vivo) · dog · 1982

6 results

Delta sleep-inducing peptide crosses the blood-brain-barrier in dogs: some correlations with protein binding.

Banks WA, Kastin AJ, Coy DH

Pharmacology, biochemistry, and behavior1 Nov 1982Cited by 42 (Europe PMC)

PMID6897451 (opens in a new tab)DOI10.1016/0091-3057(82)90486-5 (opens in a new tab)PepBankPUB-06897451
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Pharmacokinetics

    In anesthetized dogs, intravenous DSIP, desTrp1-DSIP and D-Ala3-DSIP each significantly increased immunoreactive peptide in cerebrospinal fluid.

    In plain wordsIn dogs, peptide given into a vein reached the fluid around the brain and spinal cord at higher levels.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseCSF DSIP-like immunoreactivity after IV injection
    Study

    dogn: not reported in source

    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    100 micrograms/kg bolus · intravenousAs given in this study (dog).

    Source sentences

    Summary
    Using an antibody that is highly specific for these nonapeptides, we found significant increases in CSF after IV injection of each.
    1 context sentence
    Summary · context
    To determine if the nonapeptide delta sleep-inducing peptide (DSIP) and some of its analogs can enter the cerebrospinal fluid (CSF) from the peripheral circulation, dogs anesthetized with sodium pentobarbital were injected with a 100 micrograms/kg bolus of DSIP, desTrp1-DSIP, or D-Ala3-DSIP.
  2. 02AnimalAnimal study (in vivo)Pharmacokinetics

    In dogs, column chromatography showed that the rise in CSF immunoreactivity after an IV DSIP bolus was due to DSIP and desTrp1-DSIP.

    In plain wordsIn dogs, the extra peptide found in the fluid around the brain was DSIP and one of its analogs.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Not applicableIdentity of CSF immunoreactivity after DSIP bolus (chromatography)
    Study

    dogn: not reported in source

    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    100 micrograms/kg bolus · intravenousAs given in this study (dog).

    Source sentences

    Summary
    Column chromatography of CSF withdrawn after an IV bolus of DSIP showed the increase in immunoreactivity to be due to DSIP and desTrp1-DSIP.
    1 context sentence
    Summary · context
    To determine if the nonapeptide delta sleep-inducing peptide (DSIP) and some of its analogs can enter the cerebrospinal fluid (CSF) from the peripheral circulation, dogs anesthetized with sodium pentobarbital were injected with a 100 micrograms/kg bolus of DSIP, desTrp1-DSIP, or D-Ala3-DSIP.
  3. 03AnimalAnimal study (in vivo)Pharmacokinetics

    In dogs, radioactivity in CSF after IV 125I-N-Tyr-DSIP co-eluted with the intact labeled peptide.

    In plain wordsIn dogs, labeled DSIP that reached the fluid around the brain was still intact.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Not applicableIntegrity of radiolabelled DSIP in CSF
    Study

    dogn: not reported in source

    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    100 micrograms/kg bolus · intravenousAs given in this study (dog).

    Source sentences

    Summary
    Chromatography of radioactivity appearing in the CSF after an IV bolus of 125I-N-Tyr-DSIP showed co-elution with the intact labeled peptide.
    1 context sentence
    Summary · context
    To determine if the nonapeptide delta sleep-inducing peptide (DSIP) and some of its analogs can enter the cerebrospinal fluid (CSF) from the peripheral circulation, dogs anesthetized with sodium pentobarbital were injected with a 100 micrograms/kg bolus of DSIP, desTrp1-DSIP, or D-Ala3-DSIP.
  4. 04AnimalAnimal study (in vivo)Pharmacokinetics

    In dogs, CSF/plasma ratios for DSIP and 125I-N-Tyr-DSIP were higher than the ratio for tritiated insulin injected IV.

    In plain wordsIn dogs, DSIP entered the fluid around the brain better than insulin did.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseCSF/plasma ratio of DSIP versus insulin
    Study

    dogn: not reported in source

    Comparator
    Tritiated insulin injected IV
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    100 micrograms/kg bolus · intravenousAs given in this study (dog).

    Source sentences

    Summary
    The CSF/plasma ratios for DSIP and 125I-N-Tyr-DSIP were higher than that for tritiated insulin injected IV.
    1 context sentence
    Summary · context
    To determine if the nonapeptide delta sleep-inducing peptide (DSIP) and some of its analogs can enter the cerebrospinal fluid (CSF) from the peripheral circulation, dogs anesthetized with sodium pentobarbital were injected with a 100 micrograms/kg bolus of DSIP, desTrp1-DSIP, or D-Ala3-DSIP.
  5. 05AnimalAnimal study (in vivo)Pharmacokinetics

    In dog plasma and CSF, DSIP was reversibly bound to a large molecule, and the binding was greater in blood than in CSF.

    In plain wordsIn dogs, DSIP bound loosely to a large molecule, more in blood than in the fluid around the brain.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Not applicablePlasma and CSF protein binding of DSIP
    Study

    dogn: not reported in source

    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    100 micrograms/kg bolus · intravenousAs given in this study (dog).

    Source sentences

    Summary
    It was also shown that DSIP is reversibly bound to a large molecule in dog plasma and CSF, and that the binding is greater in blood than in CSF.
    1 context sentence
    Summary · context
    To determine if the nonapeptide delta sleep-inducing peptide (DSIP) and some of its analogs can enter the cerebrospinal fluid (CSF) from the peripheral circulation, dogs anesthetized with sodium pentobarbital were injected with a 100 micrograms/kg bolus of DSIP, desTrp1-DSIP, or D-Ala3-DSIP.
  6. 06AnimalAnimal study (in vivo)Pharmacokinetics

    In dogs, the plasma binding protein bound a smaller percentage of D-Ala3-DSIP than of DSIP, and free DSIP probably crosses the blood-brain barrier.

    In plain wordsIn dogs, the binding protein held less D-Ala3-DSIP than DSIP, and free DSIP probably crosses into the brain.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Not applicableBinding protein specificity (D-Ala3-DSIP versus DSIP)
    Study

    dogn: not reported in source

    Comparator
    DSIP
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    100 micrograms/kg bolus · intravenousAs given in this study (dog).

    Source sentences

    Summary
    The binding protein demonstrates some specificity for DSIP, binding a smaller percentage of D-Ala3-DSIP
    1 context sentence
    Summary · context
    To determine if the nonapeptide delta sleep-inducing peptide (DSIP) and some of its analogs can enter the cerebrospinal fluid (CSF) from the peripheral circulation, dogs anesthetized with sodium pentobarbital were injected with a 100 micrograms/kg bolus of DSIP, desTrp1-DSIP, or D-Ala3-DSIP.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

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