Effects of delta-sleep-inducing peptide on 24-hour sleep-wake behaviour in severe chronic insomnia.

Schneider-Helmert D

European neurology1 Jan 1987Cited by 1 (Europe PMC)

PMID3622582DOI10.1159/000116143PepBankPUB-03622582

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. 6 results from people.

01HumanNon-randomized trialEfficacy outcome
In middle-aged chronic insomniacs, DSIP substantially improved night sleep with the first dose and with repeated doses.
In plain wordsIn middle-aged people with chronic insomnia, DSIP improved night sleep after the first dose and after repeated doses.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
IncreaseNight sleep
Study
n = 14
Comparator
Placebo
Outcome group
Sleep · Sleep
Studied dose
Dose not stated · 7 successive nightsAs given in this study (human).
Source sentences
Summary
The treatment substantially improved night sleep with the first and additionally with repeated doses.
2 context sentences(design, population, supporting numbers)
Summary · context
Therefore, the effects of intermediate-term delta-sleep-inducing peptide (DSIP) administration on sleep and daytime performance were investigated in 14 middle-aged chronic insomniacs.
Summary · context
DSIP was administered under placebo-controlled, double-blind conditions for 7 successive nights.
Report a problemFND-0362258201
02HumanNon-randomized trialEfficacy outcome
In middle-aged chronic insomniacs, the sleep improvement was maintained on the first posttreatment placebo night.
In plain wordsIn middle-aged people with chronic insomnia, the sleep improvement from DSIP lasted into the first night after treatment ended.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
IncreaseNight sleep on first posttreatment placebo night
Study
n = 14
Comparator
Placebo
Outcome group
Sleep · Sleep
Studied dose
Dose not stated · 7 successive nightsAs given in this study (human).
Source sentences
Summary
These effects were maintained for the first posttreatment (placebo) night.
2 context sentences(design, population, supporting numbers)
Summary · context
Therefore, the effects of intermediate-term delta-sleep-inducing peptide (DSIP) administration on sleep and daytime performance were investigated in 14 middle-aged chronic insomniacs.
Summary · context
DSIP was administered under placebo-controlled, double-blind conditions for 7 successive nights.
Report a problemFND-0362258202
03HumanNon-randomized trialEfficacy outcome
In middle-aged chronic insomniacs, DSIP raised the efficiency of night sleep to the level of normal controls.
In plain wordsIn middle-aged people with chronic insomnia, DSIP raised sleep efficiency to the level of normal controls.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
IncreaseEfficiency of night sleep
Study
n = 14
Comparator
Placebo
Outcome group
Sleep · Sleep
Studied dose
Dose not stated · 7 successive nightsAs given in this study (human).
Source sentences
Summary
Efficiency of night sleep and daytime rest reached the levels of normal controls.
2 context sentences(design, population, supporting numbers)
Summary · context
Therefore, the effects of intermediate-term delta-sleep-inducing peptide (DSIP) administration on sleep and daytime performance were investigated in 14 middle-aged chronic insomniacs.
Summary · context
DSIP was administered under placebo-controlled, double-blind conditions for 7 successive nights.
Report a problemFND-0362258203
04HumanNon-randomized trialEfficacy outcome
In middle-aged chronic insomniacs, DSIP raised the efficiency of daytime rest to the level of normal controls.
In plain wordsIn middle-aged people with chronic insomnia, DSIP raised daytime rest efficiency to the level of normal controls.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
IncreaseEfficiency of daytime rest
Study
n = 14
Comparator
Placebo
Outcome group
Sleep · Sleep
Studied dose
Dose not stated · 7 successive nightsAs given in this study (human).
Source sentences
Summary
Efficiency of night sleep and daytime rest reached the levels of normal controls.
2 context sentences(design, population, supporting numbers)
Summary · context
Therefore, the effects of intermediate-term delta-sleep-inducing peptide (DSIP) administration on sleep and daytime performance were investigated in 14 middle-aged chronic insomniacs.
Summary · context
DSIP was administered under placebo-controlled, double-blind conditions for 7 successive nights.
Report a problemFND-0362258204
05HumanNon-randomized trialEfficacy outcome
In middle-aged chronic insomniacs, daytime alertness increased significantly with DSIP.
In plain wordsIn middle-aged people with chronic insomnia, daytime alertness was higher after DSIP treatment.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
IncreaseDaytime alertness
Study
n = 14
Comparator
Placebo
Outcome group
Cognition and memory · Sleep
Studied dose
Dose not stated · 7 successive nightsAs given in this study (human).
Source sentences
Summary
Alertness and performance at daytime increased significantly.
2 context sentences(design, population, supporting numbers)
Summary · context
Therefore, the effects of intermediate-term delta-sleep-inducing peptide (DSIP) administration on sleep and daytime performance were investigated in 14 middle-aged chronic insomniacs.
Summary · context
DSIP was administered under placebo-controlled, double-blind conditions for 7 successive nights.
Report a problemFND-0362258205
06HumanNon-randomized trialEfficacy outcome
In middle-aged chronic insomniacs, daytime performance increased significantly with DSIP.
In plain wordsIn middle-aged people with chronic insomnia, daytime performance was higher after DSIP treatment.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
IncreaseDaytime performance
Study
n = 14
Comparator
Placebo
Outcome group
Cognition and memory · Sleep
Studied dose
Dose not stated · 7 successive nightsAs given in this study (human).
Source sentences
Summary
Alertness and performance at daytime increased significantly.
2 context sentences(design, population, supporting numbers)
Summary · context
Therefore, the effects of intermediate-term delta-sleep-inducing peptide (DSIP) administration on sleep and daytime performance were investigated in 14 middle-aged chronic insomniacs.
Summary · context
DSIP was administered under placebo-controlled, double-blind conditions for 7 successive nights.
Report a problemFND-0362258206

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
9 Oct 2026, 18:17 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

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