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Study · Animal study (in vivo) · rat · 2004

4 results

Delta sleep-inducing peptide and its tetrapeptide analogue alleviate severity of metaphit seizures.

Stanojlović O, Zivanović D, Mirković S, Mikhaleva I

Pharmacology, biochemistry, and behavior1 Feb 2004Cited by 7 (Europe PMC)

PMID14751449 (opens in a new tab)DOI10.1016/j.pbb.2003.10.014 (opens in a new tab)PepBankPUB-14751449
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In male Wistar rats with metaphit-induced seizures, DSIP significantly increased EEG power spectra of delta waves.

    In plain wordsIn rats with induced seizures, DSIP raised the power of slow delta brain waves.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseDelta-wave power spectra
    Study

    ratn: not reported in source

    metaphit-induced audiogenic seizures
    Outcome group
    Seizures · Nervous system and cognition
    Studied dose
    Dose not stated · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Both DSIP and DSIP(1-4) significantly increased power spectra of delta waves and decreased incidence of seizures, mean seizure grade and tonic component of metaphit-induced convulsions.
    1 context sentence
    Summary · context
    Five groups of adult male Wistar rats were intraperitoneally treated with (1) saline, (2) metaphit, (3) DSIP, (4) metaphit+DSIP and (5) metaphit+DSIP(1-4).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In male Wistar rats with metaphit-induced audiogenic seizures, DSIP decreased the incidence of seizures.

    In plain wordsIn rats with induced seizures, DSIP lowered how often seizures happened.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseSeizure incidence
    Study

    ratn: not reported in source

    metaphit-induced audiogenic seizures
    Outcome group
    Seizures · Nervous system and cognition
    Studied dose
    Dose not stated · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Both DSIP and DSIP(1-4) significantly increased power spectra of delta waves and decreased incidence of seizures, mean seizure grade and tonic component of metaphit-induced convulsions.
    1 context sentence
    Summary · context
    Five groups of adult male Wistar rats were intraperitoneally treated with (1) saline, (2) metaphit, (3) DSIP, (4) metaphit+DSIP and (5) metaphit+DSIP(1-4).
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In male Wistar rats with metaphit-induced audiogenic seizures, DSIP decreased mean seizure grade.

    In plain wordsIn rats with induced seizures, DSIP lowered how severe the seizures were.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseMean seizure grade
    Study

    ratn: not reported in source

    metaphit-induced audiogenic seizures
    Outcome group
    Seizures · Nervous system and cognition
    Studied dose
    Dose not stated · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Both DSIP and DSIP(1-4) significantly increased power spectra of delta waves and decreased incidence of seizures, mean seizure grade and tonic component of metaphit-induced convulsions.
    1 context sentence
    Summary · context
    Five groups of adult male Wistar rats were intraperitoneally treated with (1) saline, (2) metaphit, (3) DSIP, (4) metaphit+DSIP and (5) metaphit+DSIP(1-4).
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In male Wistar rats with metaphit-induced audiogenic seizures, DSIP decreased the tonic component of convulsions.

    In plain wordsIn rats with induced seizures, DSIP reduced the stiff, tonic part of the convulsions.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseTonic component of convulsions
    Study

    ratn: not reported in source

    metaphit-induced audiogenic seizures
    Outcome group
    Seizures · Nervous system and cognition
    Studied dose
    Dose not stated · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Both DSIP and DSIP(1-4) significantly increased power spectra of delta waves and decreased incidence of seizures, mean seizure grade and tonic component of metaphit-induced convulsions.
    1 context sentence
    Summary · context
    Five groups of adult male Wistar rats were intraperitoneally treated with (1) saline, (2) metaphit, (3) DSIP, (4) metaphit+DSIP and (5) metaphit+DSIP(1-4).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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