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Study · Ex vivo tissue · 1999

5 results

[Interaction of delta-sleep-inducing peptide with cell membranes in vitro].

Rikhireva GT, Golubev IN, Kopylovskiĭ SA, Prudchenko IA, Mikhaleva II

Bioorganicheskaia khimiia1 May 1999

PMID10495890 (opens in a new tab)PepBankPUB-10495890
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueMechanism

    In human erythrocyte suspension, DSIP significantly increased the mobility of the hydrophobic area of the membrane bilayer at a depth of 20-22 A.

    In plain wordsIn lab tests, DSIP made the inner part of human red blood cell membranes more mobile.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseMobility of the membrane bilayer at 20-22 A depth
    Study

    humann: not reported in source

    human donor erythrocyte membranes
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The application of paramagnetic probes, 5-, 12-, and 16-doxylstearic acids and 3-doxylandrostanol, demonstrated that the introduction of DSIP in an erythrocytic suspension significantly increased the mobility of the hydrophobic area of the membrane bilayer both at a depth of 20-22 A and in the subsurface area (4-6 A).
    1 context sentence
    Summary · context
    The effect of delta-sleep-inducing peptide (DSIP) on erythrocytic membranes of human donor blood was studied by the spin label and spin probe methods.
  2. 02LabEx vivo tissueMechanism

    In human erythrocyte suspension, DSIP significantly increased the mobility of the membrane bilayer in the subsurface area (4-6 A).

    In plain wordsIn lab tests, DSIP made the outer layer of human red blood cell membranes more mobile.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseMobility of the membrane bilayer in the subsurface area
    Study

    humann: not reported in source

    human donor erythrocyte membranes
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The application of paramagnetic probes, 5-, 12-, and 16-doxylstearic acids and 3-doxylandrostanol, demonstrated that the introduction of DSIP in an erythrocytic suspension significantly increased the mobility of the hydrophobic area of the membrane bilayer both at a depth of 20-22 A and in the subsurface area (4-6 A).
    1 context sentence
    Summary · context
    The effect of delta-sleep-inducing peptide (DSIP) on erythrocytic membranes of human donor blood was studied by the spin label and spin probe methods.
  3. 03LabEx vivo tissueMechanism

    In human erythrocyte suspension, DSIP caused maximal disordering of membrane lipids at concentrations of 10(-9) and 10(-6) M.

    In plain wordsIn lab tests, DSIP disordered human red blood cell membrane fats most at two concentrations.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseMembrane lipid disordering by DSIP concentration
    Study

    humann: not reported in source

    human donor erythrocyte membranes
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    10(-9) and 10(-6) MAs given in this study (human).

    Source sentences

    Summary
    The maximal disordering of membrane lipids was observed at peptide concentrations of 10(-9) and 10(-6) M.
    1 context sentence
    Summary · context
    The effect of delta-sleep-inducing peptide (DSIP) on erythrocytic membranes of human donor blood was studied by the spin label and spin probe methods.

Studies that did not test the peptide alone2

In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Delta sleep-inducing peptide (DSIP).

  1. 04LabNot a test of Delta sleep-inducing peptide (DSIP) aloneEx vivo tissueMechanism

    A spin-labeled DSIP derivative incubated with human erythrocytes showed a lower rotational correlation time than in phosphate buffer.

    In plain wordsIn lab tests, a labeled DSIP derivative moved more freely with red blood cells than in buffer alone.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseRotational correlation time of spin-labeled DSIP derivative
    Study

    humann: not reported in source

    human donor erythrocyte membranes
    Comparator
    Peptide in phosphate buffer
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    An analysis of the ESR spectra of the spin-labeled DSIP derivative recorded after its incubation with a human erythrocyte suspension at 37 degrees C revealed a decrease in the rotational correlation time (tau c) and molecular order parameter (S) in comparison with the control solutions of the peptid…
    1 context sentence
    Summary · context
    The effect of delta-sleep-inducing peptide (DSIP) on erythrocytic membranes of human donor blood was studied by the spin label and spin probe methods.

    In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).

  2. 05LabNot a test of Delta sleep-inducing peptide (DSIP) aloneEx vivo tissueMechanism

    A spin-labeled DSIP derivative incubated with human erythrocytes showed a lower molecular order parameter than in phosphate buffer.

    In plain wordsIn lab tests, a labeled DSIP derivative was less ordered with red blood cells than in buffer alone.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseMolecular order parameter of spin-labeled DSIP derivative
    Study

    humann: not reported in source

    human donor erythrocyte membranes
    Comparator
    Peptide in phosphate buffer
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    An analysis of the ESR spectra of the spin-labeled DSIP derivative recorded after its incubation with a human erythrocyte suspension at 37 degrees C revealed a decrease in the rotational correlation time (tau c) and molecular order parameter (S) in comparison with the control solutions of the peptid…
    1 context sentence
    Summary · context
    The effect of delta-sleep-inducing peptide (DSIP) on erythrocytic membranes of human donor blood was studied by the spin label and spin probe methods.

    In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 17:28 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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