Regulation of free radical processes by delta-sleep inducing peptide in rat tissues under cold stress.

Shustanova TA, Bondarenko TI, Milyutina NP, Mikhaleva II

Biochemistry. Biokhimiia1 Jun 2001Cited by 6 (Europe PMC)

PMID11421812DOI10.1023/a:1010255230338PepBankPUB-11421812

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Mechanism
In intact rats, intraperitoneal DSIP increased the activities of antioxidant enzymes (superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase) in tissues and erythrocytes.
In plain wordsIn rats, DSIP raised the activity of antioxidant enzymes in tissues and red blood cells.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
IncreaseAntioxidant enzyme activities in tissues and erythrocytes (intact rats)
Study
ratn: not reported in source
Outcome group
Oxidative stress · Whole body
Studied dose
12 ug/100 g body weight · intraperitonealAs given in this study (rat).
Source sentences
Summary
the activities of antioxidant enzymes (superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase) and the concentrations of antioxidants (reduced glutathione in particular) increased
1 context sentence(design, population, supporting numbers)
Summary · context
An intraperitoneal injection of an exogenous delta-sleep inducing peptide (DSIP) at a dose of 12 microg/100 g body weight
Report a problemFND-1142181201
02AnimalAnimal study (in vivo)Mechanism
In intact rats, intraperitoneal DSIP increased concentrations of antioxidants, reduced glutathione in particular.
In plain wordsIn rats, DSIP raised levels of antioxidants, especially reduced glutathione.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
IncreaseAntioxidant concentrations incl. reduced glutathione (intact rats)
Study
ratn: not reported in source
Outcome group
Oxidative stress · Whole body
Studied dose
12 ug/100 g body weight · intraperitonealAs given in this study (rat).
Source sentences
Summary
the concentrations of antioxidants (reduced glutathione in particular) increased
1 context sentence(design, population, supporting numbers)
Summary · context
An intraperitoneal injection of an exogenous delta-sleep inducing peptide (DSIP) at a dose of 12 microg/100 g body weight
Report a problemFND-1142181202
03AnimalAnimal study (in vivo)Mechanism
In intact rats, DSIP stimulated myeloperoxidase activity in blood neutrophils.
In plain wordsIn rats, DSIP raised the activity of an enzyme in white blood cells.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
IncreaseMyeloperoxidase activity in blood neutrophils (intact rats)
Study
ratn: not reported in source
Outcome group
Oxidative stress · Whole body
Studied dose
Dose not stated
Source sentences
Summary
The DSIP stimulated the myeloperoxidase activity in blood neutrophils and had no effect on the activity of xanthine oxidase, a prooxidant enzyme, in the brain and liver.
Report a problemFND-1142181203
04AnimalAnimal study (in vivo)Mechanism
In intact rats, DSIP had no effect on xanthine oxidase activity in the brain and liver.
In plain wordsIn rats, DSIP did not change the activity of the pro-oxidant enzyme xanthine oxidase in brain and liver.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
No significant changeXanthine oxidase activity in brain and liver (intact rats)
Study
ratn: not reported in source
Outcome group
Oxidative stress · Whole body
Studied dose
Dose not stated
Source sentences
Summary
had no effect on the activity of xanthine oxidase, a prooxidant enzyme, in the brain and liver.
Report a problemFND-1142181204
05AnimalAnimal study (in vivo)Mechanism
In cold-stressed rats, preliminary DSIP administration normalized myeloperoxidase activity in blood neutrophils.
In plain wordsIn cold-stressed rats, DSIP given beforehand brought the activity of a white blood cell enzyme back to normal.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
IncreaseMyeloperoxidase activity in blood neutrophils (cold stress)
Study
ratn: not reported in source
Outcome group
Oxidative stress · Whole body
Studied dose
Dose not stated
Source sentences
Summary
Preliminary administration of DSIP to animals exposed to cold stress restored the prooxidant-antioxidant balance: it normalized the myeloperoxidase activity in blood neutrophils
1 context sentence(design, population, supporting numbers)
Summary · context
Cold stress displaced the prooxidant-antioxidant balance by increasing the xanthine oxidase activity in tissues and decreasing the myeloperoxidase activity in blood neutrophils; it also inhibited the enzyme antioxidant activities in tissues and erythrocytes that was neutralized by an increased cerul…
Report a problemFND-1142181205
06AnimalAnimal study (in vivo)Mechanism
In cold-stressed rats, preliminary DSIP administration decreased xanthine oxidase activity.
In plain wordsIn cold-stressed rats, DSIP given beforehand lowered the activity of the pro-oxidant enzyme xanthine oxidase.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
DecreaseXanthine oxidase activity (cold stress)
Study
ratn: not reported in source
Outcome group
Oxidative stress · Whole body
Studied dose
Dose not stated
Source sentences
Summary
Preliminary administration of DSIP to animals exposed to cold stress restored the prooxidant-antioxidant balance: it normalized the myeloperoxidase activity in blood neutrophils, decreased the xanthine oxidase activity, and increased the activity of antioxidant enzymes in tissues and erythrocytes re…
1 context sentence(design, population, supporting numbers)
Summary · context
Cold stress displaced the prooxidant-antioxidant balance by increasing the xanthine oxidase activity in tissues and decreasing the myeloperoxidase activity in blood neutrophils; it also inhibited the enzyme antioxidant activities in tissues and erythrocytes that was neutralized by an increased cerul…
Report a problemFND-1142181206
07AnimalAnimal study (in vivo)Mechanism
In cold-stressed rats, preliminary DSIP administration increased the activity of antioxidant enzymes in tissues and erythrocytes.
In plain wordsIn cold-stressed rats, DSIP given beforehand raised antioxidant enzyme activity in tissues and red blood cells.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
IncreaseAntioxidant enzyme activities in tissues and erythrocytes (cold stress)
Study
ratn: not reported in source
Outcome group
Oxidative stress · Whole body
Studied dose
Dose not stated
Source sentences
Summary
increased the activity of antioxidant enzymes in tissues and erythrocytes
1 context sentence(design, population, supporting numbers)
Summary · context
Cold stress displaced the prooxidant-antioxidant balance by increasing the xanthine oxidase activity in tissues and decreasing the myeloperoxidase activity in blood neutrophils; it also inhibited the enzyme antioxidant activities in tissues and erythrocytes that was neutralized by an increased cerul…
Report a problemFND-1142181207
08AnimalAnimal study (in vivo)Mechanism
In cold-stressed rats, preliminary DSIP administration restored the antioxidant level; the direction is not stated.
In plain wordsIn cold-stressed rats, DSIP given beforehand restored the level of antioxidants.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
Direction not reportedAntioxidant level (cold stress)
Study
ratn: not reported in source
Outcome group
Oxidative stress · Whole body
Studied dose
Dose not stated
Source sentences
Summary
restoring the antioxidant level.
1 context sentence(design, population, supporting numbers)
Summary · context
Cold stress displaced the prooxidant-antioxidant balance by increasing the xanthine oxidase activity in tissues and decreasing the myeloperoxidase activity in blood neutrophils; it also inhibited the enzyme antioxidant activities in tissues and erythrocytes that was neutralized by an increased cerul…
Report a problemFND-1142181208

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 08:55 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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