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Study · Animal study (in vivo) · rat · 1982

2 results

DSIP-induced changes of the daily concentrations of brain neurotransmitters and plasma proteins in rats.

Graf M, Baumann JB, Girard J, Tobler HJ, Schoenenberger GA

Pharmacology, biochemistry, and behavior1 Sept 1982Cited by 15 (Europe PMC)

PMID6128743 (opens in a new tab)DOI10.1016/0091-3057(82)90312-4 (opens in a new tab)PepBankPUB-06128743
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In rats, DSIP given in the morning or evening changed nearly all measured brain neurotransmitter, plasma protein and corticosterone parameters.

    In plain wordsIn rats, DSIP changed nearly all measured brain chemicals and blood proteins, and the effects differed by time of day.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Direction not reportedBrain neurotransmitters, plasma proteins and corticosterone
    Study

    ratn: not reported in source

    rat in vivo
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    30 nmol/kg · intravenousAs given in this study (rat).

    Source sentences

    Summary
    DSIP administered in the morning or in the evening respectively induced changes in nearly all measured parameters. Different effects were observed for different times of administration.
    1 context sentence
    Summary · context
    The influence of delta sleep-inducing peptide (DSIP) on the brain neurotransmitters 5-HT, dopamine and norepinephrine and plasma proteins/corticosterone concentrations for four time points within the 24 hr following IV injection of 30 nmol/kg was investigated in rats.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rats, DSIP produced its most marked change in brain serotonin level during daytime.

    In plain wordsIn rats, DSIP changed brain serotonin level most clearly during daytime.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Direction not reportedSerotonin level during daytime
    Study

    ratn: not reported in source

    rat in vivo
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    30 nmol/kg · intravenousAs given in this study (rat).

    Source sentences

    Summary
    The most marked changes were found in the level of serotonin during daytime.
    1 context sentence
    Summary · context
    The influence of delta sleep-inducing peptide (DSIP) on the brain neurotransmitters 5-HT, dopamine and norepinephrine and plasma proteins/corticosterone concentrations for four time points within the 24 hr following IV injection of 30 nmol/kg was investigated in rats.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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