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Study · Animal study (in vivo) · rat · 1981

2 results

Effects of repeated DSIP and DSIP-P administration on the circadian locomotor activity of rats.

Graf M, Christen H, Tobler HJ, Maier PF, Schoenenberger GA

Pharmacology, biochemistry, and behavior1 Nov 1981Cited by 26 (Europe PMC)

PMID6895555 (opens in a new tab)DOI10.1016/0091-3057(81)90011-3 (opens in a new tab)PepBankPUB-06895555
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats, after 3 days of daily DSIP injections, the normally high locomotor activity during the dark phase was reduced.

    In plain wordsIn rats, after 3 days of daily DSIP, activity during the normally active dark phase fell.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseDark-phase locomotor activity
    Study

    ratn: not reported in source

    rat in vivo, constant 24 hr light:dark cycle
    Outcome group
    Sleep · Sleep
    Studied dose
    30 nmol/kg · intravenous · daily evening injections, 3 daysAs given in this study (rat).

    Source sentences

    Summary
    After 3 days the normally high locomotor activity during the dark phase was reduced
    1 context sentence
    Summary · context
    Daily intravenous evening injections of 30 nmol/kg DSIP (Delta Sleep-Inducing Peptide) in rats adapted to a constant 24 hr light:dark cycle produced changes in the circadian locomotor behavior.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats, after 3 days of daily DSIP injections, the animals became relatively more active during the light (sleeping) phase.

    In plain wordsIn rats, after 3 days of daily DSIP, the animals were relatively more active during their normal sleeping phase.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseLight-phase locomotor activity
    Study

    ratn: not reported in source

    rat in vivo, constant 24 hr light:dark cycle
    Outcome group
    Sleep · Sleep
    Studied dose
    30 nmol/kg · intravenous · daily evening injections, 3 daysAs given in this study (rat).

    Source sentences

    Summary
    while during the light (sleeping) phase the animals became relatively more active
    1 context sentence
    Summary · context
    Daily intravenous evening injections of 30 nmol/kg DSIP (Delta Sleep-Inducing Peptide) in rats adapted to a constant 24 hr light:dark cycle produced changes in the circadian locomotor behavior.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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