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Study · Animal study (in vivo) · mouse and rat · 1984

4 results

DSIP reduces amphetamine-induced hyperthermia in mice.

Graf MV, Kastin AJ, Coy DH, Zadina JE

Physiology & behavior1 Aug 1984Cited by 13 (Europe PMC)

PMID6548818 (opens in a new tab)DOI10.1016/0031-9384(84)90114-8 (opens in a new tab)PepBankPUB-06548818
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice, DSIP pretreatment at 0.1 and 150 nmol/kg significantly reduced the temperature rise caused by d-amphetamine.

    In plain wordsIn mice, DSIP at two of the doses tested reduced the rise in body temperature caused by amphetamine.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseAmphetamine-induced rise in body temperature, DSIP 0.1 and 150 nmol/kg
    Study

    mousen: not reported in source

    d-amphetamine-induced hyperthermia
    Outcome group
    Body temperature · Whole body
    Studied dose
    0.1 and 150 nmol/kgAs given in this study (mouse).

    Source sentences

    Summary
    This effect was only significant after pretreatment with 0.1 and 150 nmol DSIP/kg, but not the other doses.
    1 context sentence
    Summary · context
    We examined this effect in mice with 9 different concentrations of DSIP in addition to D-Ala4-DSIP and an analog, DSIP-P, phosphorylated at the serine in position 7.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice, DSIP doses other than 0.1 and 150 nmol/kg did not significantly reduce the d-amphetamine temperature rise.

    In plain wordsIn mice, the other DSIP doses tested did not significantly reduce the rise in body temperature caused by amphetamine.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeAmphetamine-induced rise in body temperature, other DSIP doses
    Study

    mousen: not reported in source

    d-amphetamine-induced hyperthermia
    Outcome group
    Body temperature · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    This effect was only significant after pretreatment with 0.1 and 150 nmol DSIP/kg, but not the other doses.
    1 context sentence
    Summary · context
    We examined this effect in mice with 9 different concentrations of DSIP in addition to D-Ala4-DSIP and an analog, DSIP-P, phosphorylated at the serine in position 7.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice, DSIP did not significantly reduce the temperature rise induced by the larger d-amphetamine dose of 30 mg/kg.

    In plain wordsIn mice, DSIP did not significantly reduce the temperature rise caused by the larger amphetamine dose.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeHyperthermia induced by 30 mg/kg d-amphetamine
    Study

    mousen: not reported in source

    d-amphetamine-induced hyperthermia
    Outcome group
    Body temperature · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    nor was DSIP able to significantly reduce the increase of temperature induced by the larger dose of 30 mg/kg d-amphetamine
    1 context sentence
    Summary · context
    We examined this effect in mice with 9 different concentrations of DSIP in addition to D-Ala4-DSIP and an analog, DSIP-P, phosphorylated at the serine in position 7.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats, DSIP did not reduce the d-amphetamine-induced rise in temperature, unlike in mice.

    In plain wordsIn rats, DSIP did not reduce the rise in body temperature caused by amphetamine, unlike in mice.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeAmphetamine-induced hyperthermia in rats
    Study

    ratn: not reported in source

    d-amphetamine-induced hyperthermia (rats)
    Outcome group
    Body temperature · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    A reduction of the increased temperature was observed in mice but not in rats.
    1 context sentence
    Summary · context
    We examined this effect in mice with 9 different concentrations of DSIP in addition to D-Ala4-DSIP and an analog, DSIP-P, phosphorylated at the serine in position 7.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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