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Study · Animal study (in vivo) · rat · 1982

3 results

Differential penetration of DSIP peptides into rat brain.

Kastin AJ, Banks WA, Castellanos PF, Nissen C, Coy DH

Pharmacology, biochemistry, and behavior1 Dec 1982Cited by 32 (Europe PMC)

PMID6897680 (opens in a new tab)DOI10.1016/0091-3057(82)90118-6 (opens in a new tab)PepBankPUB-06897680
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Pharmacokinetics

    In rats, brain immunoreactivity was higher after peripheral des Trp1-DSIP and D-Ala4-DSIP (and D-Ala4-DSIP-NH2 after correction) than after the other peptides tested.

    In plain wordsIn rats, some DSIP analogs reached brain tissue at higher levels than the other tested peptides.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Not applicableBrain DSIP-like immunoreactivity by peptide
    Study

    ratn: not reported in source

    Comparator
    Other DSIP peptides
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · peripheral injectionAs given in this study (rat).

    Source sentences

    Summary
    Higher concentrations of immunoreactive material were found in brain tissue with injection of des Trp1-DSIP, D-Ala4-DSIP, and, after correction for cross-reactivity, with D-Ala4-DSIP-NH2 than with the other peptides.
    1 context sentence
    Summary · context
    Delta sleep-inducing peptide (DSIP) or five closely related peptides were injected peripherally and the levels of DSIP-like immunoreactivity measured in the brains of 100 g and 500 g rats decapitated a minute later after washout with 0.9% NaCl.
  2. 02AnimalAnimal study (in vivo)Pharmacokinetics

    In rats, both D-Ala4-substituted peptides reached higher brain concentrations in 500 g rats than in 100 g rats, possibly an age effect.

    In plain wordsIn rats, two DSIP analogs reached higher brain levels in larger rats than in smaller rats, which may relate to age.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseBrain levels of D-Ala4 analogs in 500 g versus 100 g rats
    Study

    ratn: not reported in source

    Comparator
    100 g rats
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · peripheral injectionAs given in this study (rat).

    Source sentences

    Summary
    Both peptides substituted in the fourth position with D-alanine resulted in higher concentrations in 500 g rats than in 100 g rats, indicating a possible effect of age.
    1 context sentence
    Summary · context
    Delta sleep-inducing peptide (DSIP) or five closely related peptides were injected peripherally and the levels of DSIP-like immunoreactivity measured in the brains of 100 g and 500 g rats decapitated a minute later after washout with 0.9% NaCl.
  3. 03AnimalAnimal study (in vivo)Pharmacokinetics

    In rats, the brain to blood radioactivity ratio was 5-10 fold greater after 125I-N-Tyr-DSIP than after RISA, against non-specific leakage.

    In plain wordsIn rats, labeled DSIP reached the brain at a much higher ratio than labeled albumin, which argues against simple blood contamination.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseBrain to blood ratio of radioactivity after 125I-N-Tyr-DSIP versus RISA
    Study

    ratn: not reported in source

    Comparator
    125I radioiodinated serum albumin (RISA)
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · peripheral injectionAs given in this study (rat).

    Measurements

    Brain to blood ratio fold difference
    5 to 10 fold
    125I-N-Tyr-DSIP vs RISA

    Source sentences

    Summary
    The 5-10 fold greater brain to blood ratios of radioactivity after 125I-N-Tyr-DSIP than after 125-I radioiodinated serum albumin (RISA) provided additional evidence against non-specific leakage or contamination of the brains with substantial amounts of residual blood.
    1 context sentence
    Summary · context
    Delta sleep-inducing peptide (DSIP) or five closely related peptides were injected peripherally and the levels of DSIP-like immunoreactivity measured in the brains of 100 g and 500 g rats decapitated a minute later after washout with 0.9% NaCl.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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