Skip to content

Study · Animal study (in vivo) · cat · 1987

10 results

The effects of delta-sleep-inducing peptide (DSIP) on wakefulness and sleep patterns in the cat.

Susić V, Masirević G, Totić S

Brain research1 Jun 1987Cited by 4 (Europe PMC)

PMID3620931 (opens in a new tab)DOI10.1016/0006-8993(87)90006-0 (opens in a new tab)PepBankPUB-03620931
Publisher pagePubMedAsk about this study
Jump to 10 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

10 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In cats, a single DSIP injection into the lateral ventricle significantly decreased sleep latency.

    In plain wordsIn cats, DSIP injected into the brain ventricle shortened the time to fall asleep.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseSleep latency
    Study

    catn = 10

    Outcome group
    Sleep · Sleep
    Studied dose
    7 nmol/kg · intraventricular (lateral ventricle) · single injection, 8 h monitoringAs given in this study (cat).

    Source sentences

    Summary
    A significant decrease in sleep latency and a significant increase in total sleep and in total slow wave sleep (SWS) was found following DSIP administration.
    1 context sentence
    Summary · context
    The effect of a single injection of synthetic delta-sleep-inducing peptide (DSIP, 7 nmol/kg) into the lateral ventricle of 10 cats was investigated by monitoring the sleep-wake cycle during an 8 h period.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In cats, DSIP significantly increased total sleep.

    In plain wordsIn cats, DSIP injected into the brain ventricle increased total sleep.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseTotal sleep
    Study

    catn = 10

    Outcome group
    Sleep · Sleep
    Studied dose
    7 nmol/kg · intraventricular (lateral ventricle) · single injection, 8 h monitoringAs given in this study (cat).

    Source sentences

    Summary
    A significant decrease in sleep latency and a significant increase in total sleep and in total slow wave sleep (SWS) was found following DSIP administration.
    1 context sentence
    Summary · context
    The effect of a single injection of synthetic delta-sleep-inducing peptide (DSIP, 7 nmol/kg) into the lateral ventricle of 10 cats was investigated by monitoring the sleep-wake cycle during an 8 h period.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In cats, DSIP significantly increased total slow wave sleep.

    In plain wordsIn cats, DSIP injected into the brain ventricle increased slow wave sleep.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseTotal slow wave sleep (SWS)
    Study

    catn = 10

    Outcome group
    Sleep · Sleep
    Studied dose
    7 nmol/kg · intraventricular (lateral ventricle) · single injection, 8 h monitoringAs given in this study (cat).

    Source sentences

    Summary
    A significant decrease in sleep latency and a significant increase in total sleep and in total slow wave sleep (SWS) was found following DSIP administration.
    1 context sentence
    Summary · context
    The effect of a single injection of synthetic delta-sleep-inducing peptide (DSIP, 7 nmol/kg) into the lateral ventricle of 10 cats was investigated by monitoring the sleep-wake cycle during an 8 h period.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In cats, the increase in sleep after DSIP resulted exclusively from a significant increase in deep slow wave sleep (S2).

    In plain wordsIn cats, the extra sleep after DSIP was all deep slow wave sleep.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseDeep slow wave sleep (S2)
    Study

    catn = 10

    Outcome group
    Sleep · Sleep
    Studied dose
    7 nmol/kg · intraventricular (lateral ventricle) · single injection, 8 h monitoringAs given in this study (cat).

    Source sentences

    Summary
    The increase in sleep resulted exclusively from a significant increase in deep slow wave sleep (S2)
    1 context sentence
    Summary · context
    The effect of a single injection of synthetic delta-sleep-inducing peptide (DSIP, 7 nmol/kg) into the lateral ventricle of 10 cats was investigated by monitoring the sleep-wake cycle during an 8 h period.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In cats, light slow wave sleep (S1) was significantly decreased after DSIP.

    In plain wordsIn cats, DSIP reduced light slow wave sleep.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseLight slow wave sleep (S1)
    Study

    catn = 10

    Outcome group
    Sleep · Sleep
    Studied dose
    7 nmol/kg · intraventricular (lateral ventricle) · single injection, 8 h monitoringAs given in this study (cat).

    Source sentences

    Summary
    while light slow wave sleep (S1) was significantly decreased.
    1 context sentence
    Summary · context
    The effect of a single injection of synthetic delta-sleep-inducing peptide (DSIP, 7 nmol/kg) into the lateral ventricle of 10 cats was investigated by monitoring the sleep-wake cycle during an 8 h period.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In cats, DSIP did not change total REM sleep or hourly REM sleep values.

    In plain wordsIn cats, DSIP did not change the amount of REM sleep.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeTotal REM sleep and hourly REM values
    Study

    catn = 10

    Outcome group
    Sleep · Sleep
    Studied dose
    7 nmol/kg · intraventricular (lateral ventricle) · single injection, 8 h monitoringAs given in this study (cat).

    Source sentences

    Summary
    Neither the total amount of REM sleep, nor hourly values of REM sleep were affected by DSIP application.
    1 context sentence
    Summary · context
    The effect of a single injection of synthetic delta-sleep-inducing peptide (DSIP, 7 nmol/kg) into the lateral ventricle of 10 cats was investigated by monitoring the sleep-wake cycle during an 8 h period.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In cats, REM sleep latency, mean episode number and mean episode length after DSIP did not differ from control conditions.

    In plain wordsIn cats, DSIP did not change how soon REM sleep started or how often or how long REM episodes lasted.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeREM sleep latency, episode number and episode length
    Study

    catn = 10

    Comparator
    Control conditions
    Outcome group
    Sleep · Sleep
    Studied dose
    7 nmol/kg · intraventricular (lateral ventricle) · single injection, 8 h monitoringAs given in this study (cat).

    Source sentences

    Summary
    Additional measures of REM sleep, like REM sleep latency, mean episode number and mean episode length were not different from those found in control conditions.
    1 context sentence
    Summary · context
    The effect of a single injection of synthetic delta-sleep-inducing peptide (DSIP, 7 nmol/kg) into the lateral ventricle of 10 cats was investigated by monitoring the sleep-wake cycle during an 8 h period.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In cats, DSIP acted immediately: S2 rose to more than 50% in the first postinjection hour, with a highly significant difference from control.

    In plain wordsIn cats, DSIP worked at once: deep slow wave sleep rose within the first hour compared with control.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseDeep slow wave sleep (S2) in first postinjection hour
    Study

    catn = 10

    Comparator
    Control
    Outcome group
    Sleep · Sleep
    Studied dose
    7 nmol/kg · intraventricular (lateral ventricle) · single injection, 8 h monitoringAs given in this study (cat).

    Measurements

    S2 share of time
    > 50%
    first postinjection hour

    Source sentences

    Summary
    DSIP was immediately effective since the amount of S2 increased to more than 50% in the first postinjection hour and the difference from the control value was highly significant.
    1 context sentence
    Summary · context
    The effect of a single injection of synthetic delta-sleep-inducing peptide (DSIP, 7 nmol/kg) into the lateral ventricle of 10 cats was investigated by monitoring the sleep-wake cycle during an 8 h period.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In cats, the increase in S2 after DSIP was maintained over 7 h and had disappeared by the eighth hour.

    In plain wordsIn cats, the extra deep slow wave sleep after one DSIP injection lasted 7 hours and had gone by the eighth hour.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseDuration of S2 increase
    Study

    catn = 10

    Outcome group
    Sleep · Sleep
    Studied dose
    7 nmol/kg · intraventricular (lateral ventricle) · single injection, 8 h monitoringAs given in this study (cat).

    Source sentences

    Summary
    The increase in S2 was maintained over 7 h, and disappeared by the eighth hour.
    1 context sentence
    Summary · context
    The effect of a single injection of synthetic delta-sleep-inducing peptide (DSIP, 7 nmol/kg) into the lateral ventricle of 10 cats was investigated by monitoring the sleep-wake cycle during an 8 h period.
  10. 10AnimalAnimal study (in vivo)Mechanism

    In cats, the increase in S2 after DSIP came from longer S2 episodes and not from more frequent episodes.

    In plain wordsIn cats, DSIP made deep slow wave sleep episodes last longer, not occur more often.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseS2 episode length and frequency
    Study

    catn = 10

    Outcome group
    Sleep · Sleep
    Studied dose
    7 nmol/kg · intraventricular (lateral ventricle) · single injection, 8 h monitoringAs given in this study (cat).

    Source sentences

    Summary
    The increase in S2 was caused by a prolongation of S2 episodes and not by their more frequent occurrence.
    1 context sentence
    Summary · context
    The effect of a single injection of synthetic delta-sleep-inducing peptide (DSIP, 7 nmol/kg) into the lateral ventricle of 10 cats was investigated by monitoring the sleep-wake cycle during an 8 h period.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.