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Study · Animal study (in vivo) · rat · 2015

9 results

[THE INFLUENCE OF DELTA SLEEP-INDUCING PEPTIDE ON FUNCTIONAL STATE OF RATS HEPATOCYTES IN FOOT-SHOCK STRESS].

Belykh AE, Bobyntsev II, Kryukov AA, Dudka VT

Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova1 Jun 2015

PMID26470489 (opens in a new tab)PepBankPUB-26470489
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with acute foot-shock stress, DSIP at 120 mcg/kg normalized the stress-induced rise of malondialdehyde in liver homogenate.

    In plain wordsIn rats under acute stress, DSIP brought a liver marker of oxidative damage back to normal.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseLiver malondialdehyde in acute foot-shock stress
    Study

    ratn: not reported in source

    male Wistar rats with foot-shock stress
    Outcome group
    Oxidative stress · Liver
    Studied dose
    120 mcg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    It was observed that 120 mcg/kg peptide normalized the elevation of malondialdehyde (MDA) level in the liver homogenate caused by acute foot-shock stress
    1 context sentence
    Summary · context
    The effect of delta sleep-inducing peptide (DSIP) intraperitoneal injection in the doses of 40, 120, 360, and 1080 mcg/kg b. w. on lipid peroxidation and functional hepatocyte state in Wistar male rats subjected to acute and chronic electrical foot-shock stress was investigated.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with acute foot-shock stress, DSIP significantly decreased liver catalase activity at all investigated doses.

    In plain wordsIn rats under acute stress, DSIP lowered a liver antioxidant enzyme at every dose tested.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseLiver catalase activity in acute foot-shock stress
    Study

    ratn: not reported in source

    male Wistar rats with foot-shock stress
    Outcome group
    Oxidative stress · Liver
    Studied dose
    40, 120, 360 and 1080 mcg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    also significantly decreased catalase activity in all investigated doses.
    1 context sentence
    Summary · context
    The effect of delta sleep-inducing peptide (DSIP) intraperitoneal injection in the doses of 40, 120, 360, and 1080 mcg/kg b. w. on lipid peroxidation and functional hepatocyte state in Wistar male rats subjected to acute and chronic electrical foot-shock stress was investigated.
  3. 03AnimalAnimal study (in vivo)Other

    In rats, DSIP injection up to 40 mcg/kg increased serum aminotransferase activity.

    In plain wordsIn rats, low doses of DSIP raised blood levels of liver enzymes.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseSerum aminotransferase activity
    Study

    ratn: not reported in source

    male Wistar rats with foot-shock stress
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    up to 40 mcg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    In serum the injection of DSIP up to 40 mcg/kg increased aminotransferase activity.
    1 context sentence
    Summary · context
    The effect of delta sleep-inducing peptide (DSIP) intraperitoneal injection in the doses of 40, 120, 360, and 1080 mcg/kg b. w. on lipid peroxidation and functional hepatocyte state in Wistar male rats subjected to acute and chronic electrical foot-shock stress was investigated.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats with chronic foot-shock stress, DSIP at all doses normalized the protein synthetic function of hepatocytes.

    In plain wordsIn rats under chronic stress, DSIP at every dose brought liver cell protein production back to normal.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Not applicableProtein synthetic function of hepatocytes in chronic stress
    Study

    ratn: not reported in source

    male Wistar rats with foot-shock stress
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    40, 120, 360 and 1080 mcg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Peptide in all doses provided the normalization of protein synthetic hepatocyte function
    1 context sentence
    Summary · context
    The effect of delta sleep-inducing peptide (DSIP) intraperitoneal injection in the doses of 40, 120, 360, and 1080 mcg/kg b. w. on lipid peroxidation and functional hepatocyte state in Wistar male rats subjected to acute and chronic electrical foot-shock stress was investigated.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats with chronic foot-shock stress, DSIP at all doses increased liver catalase activity.

    In plain wordsIn rats under chronic stress, DSIP raised a liver antioxidant enzyme at every dose.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseLiver catalase activity in chronic stress
    Study

    ratn: not reported in source

    male Wistar rats with foot-shock stress
    Outcome group
    Oxidative stress · Liver
    Studied dose
    40, 120, 360 and 1080 mcg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    increased catalase and superoxide dismutase activity in chronic stress.
    1 context sentence
    Summary · context
    The effect of delta sleep-inducing peptide (DSIP) intraperitoneal injection in the doses of 40, 120, 360, and 1080 mcg/kg b. w. on lipid peroxidation and functional hepatocyte state in Wistar male rats subjected to acute and chronic electrical foot-shock stress was investigated.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In rats with chronic foot-shock stress, DSIP at all doses increased liver superoxide dismutase activity.

    In plain wordsIn rats under chronic stress, DSIP raised another liver antioxidant enzyme at every dose.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseLiver superoxide dismutase activity in chronic stress
    Study

    ratn: not reported in source

    male Wistar rats with foot-shock stress
    Outcome group
    Oxidative stress · Liver
    Studied dose
    40, 120, 360 and 1080 mcg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    increased catalase and superoxide dismutase activity in chronic stress.
    1 context sentence
    Summary · context
    The effect of delta sleep-inducing peptide (DSIP) intraperitoneal injection in the doses of 40, 120, 360, and 1080 mcg/kg b. w. on lipid peroxidation and functional hepatocyte state in Wistar male rats subjected to acute and chronic electrical foot-shock stress was investigated.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In rats, DSIP at 40 mcg/kg significantly decreased malondialdehyde content in liver homogenate.

    In plain wordsIn rats, the lowest DSIP dose reduced a liver marker of oxidative damage.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseLiver malondialdehyde at 40 mcg/kg
    Study

    ratn: not reported in source

    male Wistar rats with foot-shock stress
    Outcome group
    Oxidative stress · Liver
    Studied dose
    40 mcg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    In addition malondialdehyde content in the liver homogenate was significantly decreased in the dose of 40 mcg/kg and in other cases it was significantly increased against the background of the common antioxidative activity reduction.
    1 context sentence
    Summary · context
    The effect of delta sleep-inducing peptide (DSIP) intraperitoneal injection in the doses of 40, 120, 360, and 1080 mcg/kg b. w. on lipid peroxidation and functional hepatocyte state in Wistar male rats subjected to acute and chronic electrical foot-shock stress was investigated.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In rats, DSIP at doses other than 40 mcg/kg significantly increased malondialdehyde in liver homogenate, against a background of reduced common antioxidative activity.

    In plain wordsIn rats, DSIP at doses other than 40 mcg/kg raised a liver marker of oxidative damage.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseLiver malondialdehyde at doses other than 40 mcg/kg
    Study

    ratn: not reported in source

    male Wistar rats with foot-shock stress
    Outcome group
    Oxidative stress · Liver
    Studied dose
    doses other than 40 mcg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    In addition malondialdehyde content in the liver homogenate was significantly decreased in the dose of 40 mcg/kg and in other cases it was significantly increased against the background of the common antioxidative activity reduction.
    1 context sentence
    Summary · context
    The effect of delta sleep-inducing peptide (DSIP) intraperitoneal injection in the doses of 40, 120, 360, and 1080 mcg/kg b. w. on lipid peroxidation and functional hepatocyte state in Wistar male rats subjected to acute and chronic electrical foot-shock stress was investigated.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In rats, DSIP at 120, 360 and 1080 mcg/kg normalized the stress-induced increase in serum alanine aminotransferase activity.

    In plain wordsIn stressed rats, DSIP brought a raised liver enzyme in the blood back to normal.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseSerum alanine aminotransferase in stress
    Study

    ratn: not reported in source

    male Wistar rats with foot-shock stress
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    120, 360 and 1080 mcg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    The stress-induced increase in serum alanine aminotransferase activity was normalized by peptide administration in the doses of 120, 360, and 1080 mcg/kg.
    1 context sentence
    Summary · context
    The effect of delta sleep-inducing peptide (DSIP) intraperitoneal injection in the doses of 40, 120, 360, and 1080 mcg/kg b. w. on lipid peroxidation and functional hepatocyte state in Wistar male rats subjected to acute and chronic electrical foot-shock stress was investigated.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 17:28 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

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