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Study · Animal study (in vivo) · rat · 1990

5 results

The effect of delta sleep-inducing peptide (DSIP) and phosphorylated DSIP (P-DSIP) on the apomorphine-induced hypothermia in rats.

Tsunashima K, Masui A, Kato N

Brain research1 Feb 1990Cited by 1 (Europe PMC)

PMID2322843 (opens in a new tab)DOI10.1016/0006-8993(90)90748-z (opens in a new tab)PepBankPUB-02322843
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats, DSIP enhanced the hypothermia induced by intraperitoneal injection of the dopamine agonist apomorphine.

    In plain wordsIn rats, DSIP made the drop in body temperature caused by apomorphine stronger.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseApomorphine-induced hypothermia
    Study

    ratn: not reported in source

    Apomorphine-induced hypothermia model
    Outcome group
    Body temperature · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Delta sleep-inducing peptide (DSIP) and P-DSIP, phosphorylated analogue, were found to have enhancing effects on hypothermia induced by i.p. injection of apomorphine (2 mg/kg), a dopamine agonist.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats, the action of DSIP on apomorphine-induced hypothermia appeared and diminished more slowly than that of P-DSIP.

    In plain wordsIn rats, the effect of DSIP began and faded more slowly than the effect of its phosphorylated form P-DSIP.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Not applicableTime course of DSIP effect versus P-DSIP
    Study

    ratn: not reported in source

    Apomorphine-induced hypothermia model
    Comparator
    P-DSIP
    Outcome group
    Body temperature · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Further, the action of P-DSIP appeared and diminished more quickly than that of DSIP.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats, DSIP and P-DSIP had a minimal effective dose of 10 ng and an inverted bell-shaped dose-response with a maximal effective dose of 1 microgram.

    In plain wordsIn rats, the smallest effective dose of these peptides was 10 ng, and the best dose was 1 microgram.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Not applicableDose-response of hypothermia enhancement
    Study

    ratn: not reported in source

    Apomorphine-induced hypothermia model
    Outcome group
    Body temperature · Nervous system and cognition
    Studied dose
    10 ng to 1 microgramAs given in this study (rat).

    Measurements

    Minimal effective dose
    10 ng
    DSIP and P-DSIP
    Maximal effective dose
    1 microgram
    DSIP and P-DSIP

    Source sentences

    Summary
    A minimal effective dose of these peptides was 10 ng and the dose-response relationship exhibited an inverted bell-shape with a maximal effective dose of 1 microgram.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In rats, pretreatment with anti-DSIP totally abolished the enhancing effect of DSIP on apomorphine-induced hypothermia.

    In plain wordsIn rats, an antibody against DSIP fully blocked the extra drop in body temperature that DSIP caused.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseDSIP effect after anti-DSIP pretreatment
    Study

    ratn: not reported in source

    Apomorphine-induced hypothermia model
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    By the pretreatment of anti-DSIP the enhancing effect of DSIP but not P-DSIP, was totally abolished
  5. 05AnimalAnimal study (in vivo)Mechanism

    In rats, haloperidol antagonized the action of DSIP and P-DSIP on apomorphine-induced hypothermia.

    In plain wordsIn rats, the dopamine blocker haloperidol worked against the effect of DSIP on body temperature.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseDSIP effect after haloperidol
    Study

    ratn: not reported in source

    Apomorphine-induced hypothermia model
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    the action of both peptides was antagonized by haloperidol.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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