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Study · Animal study (in vivo) · rat · 1985

6 results

[Effect of the delta-sleep peptide on erythrocyte membrane function during low-temperature exposure].

Bondarenko TI, Krichevskaia AA, Krupennikova EIu, Mikhaleva II

Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova1 Mar 1985Cited by 2 (Europe PMC)

PMID3838950 (opens in a new tab)PepBankPUB-03838950
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In intact rats, DSIP at 6, 12 or 18 micrograms/100 g body weight did not change the amount of extraerythrocyte hemoglobin in blood serum.

    In plain wordsIn rats at normal temperature, DSIP did not change the amount of hemoglobin outside red blood cells in the blood.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeExtraerythrocyte hemoglobin in serum of intact rats
    Study

    ratn: not reported in source

    Outcome group
    Aging markers · Whole body
    Studied dose
    6, 12 or 18 micrograms/100 g body weightAs given in this study (rat).

    Source sentences

    Summary
    Administration of 6.12 or 18 micrograms/100 g body weight of the delta-sleep peptide (DSIP) induces on change in amount of extraerythrocyte hemoglobin in the blood serum of intact rats.
    1 context sentence
    Summary · context
    3-day effect of low temperature increases the amount of extraerythrocyte hemoglobin by 64% in the blood serum, the activity of glucose-6-phosphatedehydrogenase increasing by 231%.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In intact rats, DSIP at 6 micrograms/100 g increased glucose-6-phosphate dehydrogenase activity by 251.6%.

    In plain wordsIn rats at normal temperature, a low DSIP dose raised the activity of an enzyme, glucose-6-phosphate dehydrogenase, by 251.6%.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseGlucose-6-phosphate dehydrogenase activity in intact rats
    Study

    ratn: not reported in source

    Outcome group
    Aging markers · Whole body
    Studied dose
    6 micrograms/100 g body weightAs given in this study (rat).

    Measurements

    G6PD activity increase
    251.6%
    6 micrograms/100 g DSIP

    Source sentences

    Summary
    6 micrograms/100 g DSIP increases the activity of glucose-6-phosphatedehydrogenase by 251.6%
    1 context sentence
    Summary · context
    3-day effect of low temperature increases the amount of extraerythrocyte hemoglobin by 64% in the blood serum, the activity of glucose-6-phosphatedehydrogenase increasing by 231%.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In intact rats, DSIP at 12 micrograms/100 g increased glucose-6-phosphate dehydrogenase activity by 165.6%.

    In plain wordsIn rats at normal temperature, a medium DSIP dose raised the activity of an enzyme, glucose-6-phosphate dehydrogenase, by 165.6%.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseGlucose-6-phosphate dehydrogenase activity in intact rats
    Study

    ratn: not reported in source

    Outcome group
    Aging markers · Whole body
    Studied dose
    12 micrograms/100 g body weightAs given in this study (rat).

    Measurements

    G6PD activity increase
    165.6%
    12 micrograms/100 g DSIP

    Source sentences

    Summary
    12 micrograms/100 g-- by 165.6%
    1 context sentence
    Summary · context
    3-day effect of low temperature increases the amount of extraerythrocyte hemoglobin by 64% in the blood serum, the activity of glucose-6-phosphatedehydrogenase increasing by 231%.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In intact rats, DSIP at 18 micrograms/100 g increased glucose-6-phosphate dehydrogenase activity by 90.6%.

    In plain wordsIn rats at normal temperature, a high DSIP dose raised the activity of an enzyme, glucose-6-phosphate dehydrogenase, by 90.6%.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseGlucose-6-phosphate dehydrogenase activity in intact rats
    Study

    ratn: not reported in source

    Outcome group
    Aging markers · Whole body
    Studied dose
    18 micrograms/100 g body weightAs given in this study (rat).

    Measurements

    G6PD activity increase
    90.6%
    18 micrograms/100 g DSIP

    Source sentences

    Summary
    18 micrograms/100 g--by 90.6%
    1 context sentence
    Summary · context
    3-day effect of low temperature increases the amount of extraerythrocyte hemoglobin by 64% in the blood serum, the activity of glucose-6-phosphatedehydrogenase increasing by 231%.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats exposed to low ambient temperature, DSIP at 12 micrograms/100 g body weight normalized the level of extraerythrocyte hemoglobin.

    In plain wordsIn cold-exposed rats, a DSIP dose brought hemoglobin outside red blood cells back toward normal levels.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseExtraerythrocyte hemoglobin during low temperature exposure
    Study

    ratn: not reported in source

    Outcome group
    Aging markers · Whole body
    Studied dose
    12 micrograms/100 g body weightAs given in this study (rat).

    Source sentences

    Summary
    The normalizing effect on the level of extraerythrocyte hemoglobin and activity of glucose-6-phosphatedehydrogenase in low ambient temperature occurs at the dose of DSIP 12 micrograms/100 g body weight.
    1 context sentence
    Summary · context
    3-day effect of low temperature increases the amount of extraerythrocyte hemoglobin by 64% in the blood serum, the activity of glucose-6-phosphatedehydrogenase increasing by 231%.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In rats exposed to low ambient temperature, DSIP at 12 micrograms/100 g body weight normalized glucose-6-phosphate dehydrogenase activity.

    In plain wordsIn cold-exposed rats, a DSIP dose brought the activity of an enzyme, glucose-6-phosphate dehydrogenase, back toward normal.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseGlucose-6-phosphate dehydrogenase activity during low temperature exposure
    Study

    ratn: not reported in source

    Outcome group
    Aging markers · Whole body
    Studied dose
    12 micrograms/100 g body weightAs given in this study (rat).

    Source sentences

    Summary
    The normalizing effect on the level of extraerythrocyte hemoglobin and activity of glucose-6-phosphatedehydrogenase in low ambient temperature occurs at the dose of DSIP 12 micrograms/100 g body weight.
    1 context sentence
    Summary · context
    3-day effect of low temperature increases the amount of extraerythrocyte hemoglobin by 64% in the blood serum, the activity of glucose-6-phosphatedehydrogenase increasing by 231%.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 17:28 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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