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Study · Non-randomized trial · n = 8 · 1993

6 results

Delta sleep-inducing peptide administration does not influence growth hormone and prolactin secretion in normal women.

Giusti M, Carraro A, Porcella E, Valenti S, Nicora D, Sessarego P, Giordano G

Psychoneuroendocrinology1 Jan 1993Cited by 3 (Europe PMC)

PMID8475226 (opens in a new tab)DOI10.1016/0306-4530(93)90057-r (opens in a new tab)PepBankPUB-08475226
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. 6 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In healthy women, DSIP infusion had no effect on basal serum growth hormone levels.

    In plain wordsIn healthy women, DSIP did not change growth hormone levels compared with before the infusion.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeBasal GH secretion
    Study

    n = 8

    Comparator
    Basal conditions
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    25 micrograms/kg bw · IV · 30 min infusionAs given in this study (human).

    Source sentences

    Summary
    Serum GH and PRL levels were normal under basal conditions and no effects were noted after the infusion of DSIP.
    1 context sentence
    Summary · context
    The aim of this study was to analyze the effects of delta sleep-inducing peptide (DSIP) on growth hormone (GH) and prolactin (PRL) secretion in eight healthy women with normal cycles (aged 17-36 years).
  2. 02HumanNon-randomized trialEfficacy outcome

    In healthy women, DSIP infusion had no effect on basal serum prolactin levels.

    In plain wordsIn healthy women, DSIP did not change prolactin levels compared with before the infusion.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeBasal PRL secretion
    Study

    n = 8

    Comparator
    Basal conditions
    Outcome group
    Pituitary hormones · Endocrine and hormones
    Studied dose
    25 micrograms/kg bw · IV · 30 min infusionAs given in this study (human).

    Source sentences

    Summary
    Serum GH and PRL levels were normal under basal conditions and no effects were noted after the infusion of DSIP.
    1 context sentence
    Summary · context
    The aim of this study was to analyze the effects of delta sleep-inducing peptide (DSIP) on growth hormone (GH) and prolactin (PRL) secretion in eight healthy women with normal cycles (aged 17-36 years).
  3. 03HumanNon-randomized trialEfficacy outcome

    In healthy women, DSIP did not influence the growth hormone response to arginine chlorhydrate.

    In plain wordsIn healthy women, DSIP did not change the growth hormone rise caused by arginine compared with arginine alone.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeGH response to arginine chlorhydrate
    Study

    n = 5

    Comparator
    Arginine chlorhydrate alone
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    25 micrograms/kg bw · IV · 30 min infusionAs given in this study (human).

    Source sentences

    Summary
    DSIP did not influence GH and PRL responsiveness to arginine chlorhydrate.
    2 context sentences
    Summary · context
    GH and PRL secretion was studied in five women after DSIP (25 micrograms/kg bw IV over 30 min), arginine chlorhydrate (0.5 g/kg bw IV over 30 min) and simultaneous DSIP plus arginine chlorhydrate administration.
    Summary · context
    The aim of this study was to analyze the effects of delta sleep-inducing peptide (DSIP) on growth hormone (GH) and prolactin (PRL) secretion in eight healthy women with normal cycles (aged 17-36 years).
  4. 04HumanNon-randomized trialEfficacy outcome

    In healthy women, DSIP did not influence the prolactin response to arginine chlorhydrate.

    In plain wordsIn healthy women, DSIP did not change the prolactin rise caused by arginine compared with arginine alone.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changePRL response to arginine chlorhydrate
    Study

    n = 5

    Comparator
    Arginine chlorhydrate alone
    Outcome group
    Pituitary hormones · Endocrine and hormones
    Studied dose
    25 micrograms/kg bw · IV · 30 min infusionAs given in this study (human).

    Source sentences

    Summary
    DSIP did not influence GH and PRL responsiveness to arginine chlorhydrate.
    2 context sentences
    Summary · context
    GH and PRL secretion was studied in five women after DSIP (25 micrograms/kg bw IV over 30 min), arginine chlorhydrate (0.5 g/kg bw IV over 30 min) and simultaneous DSIP plus arginine chlorhydrate administration.
    Summary · context
    The aim of this study was to analyze the effects of delta sleep-inducing peptide (DSIP) on growth hormone (GH) and prolactin (PRL) secretion in eight healthy women with normal cycles (aged 17-36 years).
  5. 05HumanNon-randomized trialEfficacy outcome

    In healthy women, DSIP did not modify the circadian rhythm of growth hormone versus placebo infusion.

    In plain wordsIn healthy women, DSIP did not change the daily rhythm of growth hormone compared with placebo.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeGH circadian rhythm
    Study

    n = 3

    Comparator
    Placebo infusion
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    25 micrograms/kg bw · IV · 1 h infusion (2130h to 2230h)As given in this study (human).

    Source sentences

    Summary
    The GH and PRL circadian rhythm was not modified by DSIP administration.
    2 context sentences
    Summary · context
    In three other women the circadian rhythm of GH and PRL was studied during DSIP (25 micrograms/kg bw from 2130h to 2230h) and placebo IV infusion.
    Summary · context
    The aim of this study was to analyze the effects of delta sleep-inducing peptide (DSIP) on growth hormone (GH) and prolactin (PRL) secretion in eight healthy women with normal cycles (aged 17-36 years).
  6. 06HumanNon-randomized trialEfficacy outcome

    In healthy women, DSIP did not modify the circadian rhythm of prolactin versus placebo infusion.

    In plain wordsIn healthy women, DSIP did not change the daily rhythm of prolactin compared with placebo.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changePRL circadian rhythm
    Study

    n = 3

    Comparator
    Placebo infusion
    Outcome group
    Pituitary hormones · Endocrine and hormones
    Studied dose
    25 micrograms/kg bw · IV · 1 h infusion (2130h to 2230h)As given in this study (human).

    Source sentences

    Summary
    The GH and PRL circadian rhythm was not modified by DSIP administration.
    2 context sentences
    Summary · context
    In three other women the circadian rhythm of GH and PRL was studied during DSIP (25 micrograms/kg bw from 2130h to 2230h) and placebo IV infusion.
    Summary · context
    The aim of this study was to analyze the effects of delta sleep-inducing peptide (DSIP) on growth hormone (GH) and prolactin (PRL) secretion in eight healthy women with normal cycles (aged 17-36 years).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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