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Study · Animal study (in vivo) · mouse · 1993

3 results

[Synthesis and biological properties of delta-sleep peptide analogs. 2. Antimetastatic effect].

Prudchenko- IA, Stashevskaia LV, Shepel' EN, Mikhaleva II, Ivanov VT, Shmal'ko IuP, Chalyĭ AP, Umanskiĭ VIu, Grinzhevskaia SN

Bioorganicheskaia khimiia1 Dec 1993Cited by 5 (Europe PMC)

PMID8117335 (opens in a new tab)PepBankPUB-08117335
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In C57B1 mice with metastatic Lewis lung carcinoma, some DSIP analogues were more efficient antimetastatic agents than DSIP after intravenous administration.

    In plain wordsIn mice with lung cancer spread, some DSIP-like compounds worked better against spread than DSIP itself.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Not applicableAntimetastatic activity of DSIP compared with analogues
    Study

    mousen: not reported in source

    metastatic Lewis lung carcinoma
    Comparator
    DSIP analogues
    Outcome group
    Tumor growth · Cancer
    Studied dose
    50 micrograms/kg · intravenousAs given in this study (mouse).

    Source sentences

    Summary
    Experiments on C57B1 mice with metastatic Lewis lung carcinoma showed some analogues to be more efficient as antimetastatic agents then DSIP after i.v. (50 micrograms/kg) administration.

Studies that did not test the peptide alone2

In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Delta sleep-inducing peptide (DSIP).

  1. 02AnimalNot a test of Delta sleep-inducing peptide (DSIP) aloneAnimal study (in vivo)Efficacy outcome

    In mice with metastatic Lewis lung carcinoma, injection of DSIP and some analogues together was reported to normalize neuroendocrine status.

    In plain wordsIn mice with lung cancer spread, DSIP and some similar compounds together brought hormone-related status toward normal. No DSIP-alone result.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    MixedNeuroendocrine status
    Study

    mousen: not reported in source

    metastatic Lewis lung carcinoma
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    Normalization of neuroendocrine status and activity of peritoneal, alveolar and spleen macrophages after the DSIP and some analogues injections in mice with metastatic Lewis lung carcinoma took place.
    1 context sentence
    Summary · context
    Experiments on C57B1 mice with metastatic Lewis lung carcinoma showed some analogues to be more efficient as antimetastatic agents then DSIP after i.v. (50 micrograms/kg) administration.

    In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).

  2. 03AnimalNot a test of Delta sleep-inducing peptide (DSIP) aloneAnimal study (in vivo)Efficacy outcome

    In mice with metastatic Lewis lung carcinoma, injection of DSIP and some analogues together was reported to normalize the activity of peritoneal, alveolar and spleen macrophages.

    In plain wordsIn mice with lung cancer spread, DSIP and some similar compounds together brought immune cell activity toward normal. No DSIP-alone result.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    MixedMacrophage activity (peritoneal, alveolar, spleen)
    Study

    mousen: not reported in source

    metastatic Lewis lung carcinoma
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    Normalization of neuroendocrine status and activity of peritoneal, alveolar and spleen macrophages after the DSIP and some analogues injections in mice with metastatic Lewis lung carcinoma took place.
    1 context sentence
    Summary · context
    Experiments on C57B1 mice with metastatic Lewis lung carcinoma showed some analogues to be more efficient as antimetastatic agents then DSIP after i.v. (50 micrograms/kg) administration.

    In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 17:28 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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