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Study · Animal study (in vivo) · rat · 2014

4 results

Effect of delta sleep-inducing peptide on the expression of antioxidant enzyme genes in the brain and blood of rats during physiological aging.

Kutilin DS, Bondarenko TI, Kornienko IV, Mikhaleva II

Bulletin of experimental biology and medicine26 Sept 2014Cited by 3 (Europe PMC)

PMID25257425 (opens in a new tab)DOI10.1007/s10517-014-2628-4 (opens in a new tab)PepBankPUB-25257425
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In rats aged 2-24 months, subcutaneous DSIP increased Sod1 gene expression in the brain.

    In plain wordsIn rats of various ages, DSIP injections raised expression of the Sod1 antioxidant gene in the brain.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseSod1 expression in brain
    Study

    ratn: not reported in source

    Physiological aging (2-24 months)
    Outcome group
    Aging markers · Aging and longevity
    Studied dose
    100 µg/kg · subcutaneous · monthly 5-day coursesAs given in this study (rat).

    Source sentences

    Summary
    Subcutaneous injections of exogenous delta sleep-inducing peptide in a dose of 100 μg/kg (monthly, 5-day courses) to rats of various age groups (2-24 months) were followed by an increase in the expression of genes for SOD 1 (Sod1) and glutathione peroxidase 1 (Gpx1) in the brain and nucleated blood cells.
    1 context sentence
    Title · context
    Effect of delta sleep-inducing peptide on the expression of antioxidant enzyme genes in the brain and blood of rats during physiological aging.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rats aged 2-24 months, subcutaneous DSIP increased Sod1 gene expression in nucleated blood cells.

    In plain wordsIn rats of various ages, DSIP injections raised expression of the Sod1 antioxidant gene in blood cells.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseSod1 expression in nucleated blood cells
    Study

    ratn: not reported in source

    Physiological aging (2-24 months)
    Outcome group
    Aging markers · Aging and longevity
    Studied dose
    100 µg/kg · subcutaneous · monthly 5-day coursesAs given in this study (rat).

    Source sentences

    Summary
    Subcutaneous injections of exogenous delta sleep-inducing peptide in a dose of 100 μg/kg (monthly, 5-day courses) to rats of various age groups (2-24 months) were followed by an increase in the expression of genes for SOD 1 (Sod1) and glutathione peroxidase 1 (Gpx1) in the brain and nucleated blood cells.
    1 context sentence
    Title · context
    Effect of delta sleep-inducing peptide on the expression of antioxidant enzyme genes in the brain and blood of rats during physiological aging.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rats aged 2-24 months, subcutaneous DSIP increased Gpx1 gene expression in the brain.

    In plain wordsIn rats of various ages, DSIP injections raised expression of the Gpx1 antioxidant gene in the brain.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseGpx1 expression in brain
    Study

    ratn: not reported in source

    Physiological aging (2-24 months)
    Outcome group
    Aging markers · Aging and longevity
    Studied dose
    100 µg/kg · subcutaneous · monthly 5-day coursesAs given in this study (rat).

    Source sentences

    Summary
    Subcutaneous injections of exogenous delta sleep-inducing peptide in a dose of 100 μg/kg (monthly, 5-day courses) to rats of various age groups (2-24 months) were followed by an increase in the expression of genes for SOD 1 (Sod1) and glutathione peroxidase 1 (Gpx1) in the brain and nucleated blood cells.
    1 context sentence
    Title · context
    Effect of delta sleep-inducing peptide on the expression of antioxidant enzyme genes in the brain and blood of rats during physiological aging.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In rats aged 2-24 months, subcutaneous DSIP increased Gpx1 gene expression in nucleated blood cells.

    In plain wordsIn rats of various ages, DSIP injections raised expression of the Gpx1 antioxidant gene in blood cells.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseGpx1 expression in nucleated blood cells
    Study

    ratn: not reported in source

    Physiological aging (2-24 months)
    Outcome group
    Aging markers · Aging and longevity
    Studied dose
    100 µg/kg · subcutaneous · monthly 5-day coursesAs given in this study (rat).

    Source sentences

    Summary
    Subcutaneous injections of exogenous delta sleep-inducing peptide in a dose of 100 μg/kg (monthly, 5-day courses) to rats of various age groups (2-24 months) were followed by an increase in the expression of genes for SOD 1 (Sod1) and glutathione peroxidase 1 (Gpx1) in the brain and nucleated blood cells.
    1 context sentence
    Title · context
    Effect of delta sleep-inducing peptide on the expression of antioxidant enzyme genes in the brain and blood of rats during physiological aging.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

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