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Study · Animal study (in vivo) · mouse · 1988

4 results

[Antimetastatic effect of the delta-sleep peptide during stress in mice with Lewis' lung carcinoma].

Shmal'ko IuP, Mikhaleva II

Eksperimental'naia onkologiia1 Jan 1988

PMID2899023 (opens in a new tab)PepBankPUB-02899023
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice with Lewis lung carcinoma, DSIP lowered the stimulation of metastatic spreading seen after tumour removal together with emotional-painful stress.

    In plain wordsIn mice with lung cancer, DSIP reduced the stress-driven spread of cancer after surgery.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseStress-stimulated metastatic spreading
    Study

    mousen: not reported in source

    C57Bl mice with metastatic Lewis lung carcinoma, surgery plus emotional-painful stress
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    peptide delta-sleep (DSIP) lowers the stimulation of metastatic spreading which is observed in combination of the surgical removal of the tumour with the emotional-painful stress.
    1 context sentence
    Summary · context
    The experiments on C57Bl mice with metastatic Lewis lung carcinoma have shown that peptide delta-sleep (DSIP) lowers the stimulation of metastatic spreading which is observed in combination of the surgical removal of the tumour with the emotional-painful stress.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In mice with Lewis lung carcinoma, the antimetastatic effect of DSIP was accompanied by stabilization of neurohumoral indices.

    In plain wordsIn mice with lung cancer, DSIP's effect on cancer spread came with more stable neurohumoral measures.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Not applicableNeurohumoral indices
    Study

    mousen: not reported in source

    C57Bl mice with metastatic Lewis lung carcinoma, surgery plus emotional-painful stress
    Outcome group
    Receptor activity and mechanism · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The antimetastatic effect is accompanied by stabilization of neurohumoral indices
    1 context sentence
    Summary · context
    The experiments on C57Bl mice with metastatic Lewis lung carcinoma have shown that peptide delta-sleep (DSIP) lowers the stimulation of metastatic spreading which is observed in combination of the surgical removal of the tumour with the emotional-painful stress.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In mice with Lewis lung carcinoma, the antimetastatic effect of DSIP was accompanied by a decrease in lipid peroxidation in blood vessels and lung tissue.

    In plain wordsIn mice with lung cancer, DSIP's effect on cancer spread came with less fat oxidation damage in blood vessels and lung.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseLipid peroxidation intensity in blood vessels and lung tissue
    Study

    mousen: not reported in source

    C57Bl mice with metastatic Lewis lung carcinoma, surgery plus emotional-painful stress
    Outcome group
    Inflammation markers · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    a decrease in the intensity of lipid peroxidation and of the acid cathepsin activity in the blood vessels and in the lung tissue.
    1 context sentence
    Summary · context
    The experiments on C57Bl mice with metastatic Lewis lung carcinoma have shown that peptide delta-sleep (DSIP) lowers the stimulation of metastatic spreading which is observed in combination of the surgical removal of the tumour with the emotional-painful stress.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In mice with Lewis lung carcinoma, the antimetastatic effect of DSIP was accompanied by a decrease in acid cathepsin activity in blood vessels and lung tissue.

    In plain wordsIn mice with lung cancer, DSIP's effect on cancer spread came with lower activity of an enzyme in blood vessels and lung.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseAcid cathepsin activity in blood vessels and lung tissue
    Study

    mousen: not reported in source

    C57Bl mice with metastatic Lewis lung carcinoma, surgery plus emotional-painful stress
    Outcome group
    Inflammation markers · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    a decrease in the intensity of lipid peroxidation and of the acid cathepsin activity in the blood vessels and in the lung tissue.
    1 context sentence
    Summary · context
    The experiments on C57Bl mice with metastatic Lewis lung carcinoma have shown that peptide delta-sleep (DSIP) lowers the stimulation of metastatic spreading which is observed in combination of the surgical removal of the tumour with the emotional-painful stress.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 17:28 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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