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Study · Animal study (in vivo) · rat · 1979

3 results

Additional evidence that small amounts of a peptide can cross the blood-brain barrier.

Kastin AJ, Nissen C, Schally AV, Coy DH

Pharmacology, biochemistry, and behavior1 Dec 1979Cited by 65 (Europe PMC)

PMID583452 (opens in a new tab)DOI10.1016/0091-3057(79)90269-7 (opens in a new tab)PepBankPUB-00583452
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Pharmacokinetics

    In rats, injecting 200 microgram DSIP into the carotid artery doubled brain levels of peptide measured shortly afterwards by RIA.

    In plain wordsIn rats, DSIP injected into an artery to the head doubled DSIP-like levels in the brain shortly afterwards.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseRat brain DSIP-like levels after intracarotid DSIP
    Study

    ratn: not reported in source

    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    200 microgram · carotid artery injectionAs given in this study (rat).

    Source sentences

    Summary
    Injection of 200 microgram DSIP into the carotid artery of rats resulted in a doubling of brain levels of peptide as measured shortly afterwards by RIA.
  2. 02AnimalAnimal study (in vivo)Pharmacokinetics

    In rats, the brain tissue to plasma ratio of radioactivity was much higher after labeled DSIP than after labeled inulin.

    In plain wordsIn rats, labeled DSIP reached brain tissue at a much higher ratio than labeled inulin, so it was not just trapped in blood vessels.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseBrain tissue to plasma radioactivity ratio of labeled DSIP versus inulin
    Study

    ratn: not reported in source

    Comparator
    Labeled inulin
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The brain tissue to plasma ratio of radioactivity in rats injected with labeled DSIP was much higher than that in rats injected with labeled inulin; this suggests that the increased amount of material measured by RIA was not merely trapped in the blood vessels.

Studies that did not test the peptide alone1

In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Delta sleep-inducing peptide (DSIP).

  1. 03LabNot a test of Delta sleep-inducing peptide (DSIP) aloneIn vitro (cell-free)Other

    An antiserum against DSIP required eight of the nine amino acids for antigenic activity.

    In plain wordsIn lab tests, an antibody against DSIP needed eight of its nine amino acids to detect it.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Not applicableAntiserum requirement for antigenic activity
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    It was determined that an antiserum against delta-sleep inducing peptide (DSIP) required eight of the nine constituent amino acids for antigenic activity.

    In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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