Some pharmacological effects of delta-sleep-inducing peptide (DSIP).

Scherschlicht R, Aeppli L, Polc P, Haefely W

European neurology1 Jan 1984Cited by 20 (Europe PMC)

PMID6548967DOI10.1159/000115712PepBankPUB-06548967

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rabbits, DSIP given intravenously or subcutaneously increased spindle-dominated, light non-REM sleep.
In plain wordsIn rabbits, DSIP increased light non-REM sleep.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
IncreaseSpindle-dominated light non-REM sleep
Study
rabbitn: not reported in source
normal conditions and disturbed sleep
Outcome group
Sleep · Sleep
Studied dose
25 micrograms/kg i.v.; 1 mg/kg s.c. · intravenous; subcutaneousAs given in this study (rabbit).
Source sentences
Summary
In rabbits, DSIP at 25 micrograms X kg-1 i.v. and 1 mg X kg-1 s.c. augmented spindle-dominated, light nonREM sleep
1 context sentence(design, population, supporting numbers)
Summary · context
The synthetic nonapeptide DSIP was studied in rabbits and cats under normal conditions and under conditions of disturbed sleep.
Report a problemFND-0654896701
02AnimalAnimal study (in vivo)Efficacy outcome
In rabbits, DSIP prevented the loss of sleep (hyposomnia) that follows a stressful situation.
In plain wordsIn rabbits, DSIP prevented poor sleep after a stressful event.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
DecreaseHyposomnia after a stressful situation
Study
rabbitn: not reported in source
normal conditions and disturbed sleep
Outcome group
Sleep · Sleep
Studied dose
25 micrograms/kg i.v.; 1 mg/kg s.c. · intravenous; subcutaneousAs given in this study (rabbit).
Source sentences
Summary
In rabbits, DSIP at 25 micrograms X kg-1 i.v. and 1 mg X kg-1 s.c. augmented spindle-dominated, light nonREM sleep and prevented hyposomnia after a stressful situation.
1 context sentence(design, population, supporting numbers)
Summary · context
The synthetic nonapeptide DSIP was studied in rabbits and cats under normal conditions and under conditions of disturbed sleep.
Report a problemFND-0654896702
03AnimalAnimal study (in vivo)Efficacy outcome
In cats, DSIP given intravenously or subcutaneously preferentially increased REM sleep.
In plain wordsIn cats, DSIP mainly increased REM sleep.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
IncreaseREM sleep
Study
catn: not reported in source
normal conditions and disturbed sleep
Outcome group
Sleep · Sleep
Studied dose
25 micrograms/kg i.v.; 100 micrograms/kg s.c. · intravenous; subcutaneousAs given in this study (cat).
Source sentences
Summary
In cats, 25 micrograms X kg-1 i.v. and 100 micrograms X kg-1 s.c. preferentially augmented REM sleep
1 context sentence(design, population, supporting numbers)
Summary · context
The synthetic nonapeptide DSIP was studied in rabbits and cats under normal conditions and under conditions of disturbed sleep.
Report a problemFND-0654896703
04AnimalAnimal study (in vivo)Efficacy outcome
In cats, DSIP abolished the sleep-suppressing effect of morphine.
In plain wordsIn cats, DSIP removed the sleep-suppressing effect of morphine.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
DecreaseMorphine-induced sleep suppression
Study
catn: not reported in source
normal conditions and disturbed sleep
Outcome group
Sleep · Sleep
Studied dose
25 micrograms/kg i.v.; 100 micrograms/kg s.c. · intravenous; subcutaneousAs given in this study (cat).
Source sentences
Summary
In cats, 25 micrograms X kg-1 i.v. and 100 micrograms X kg-1 s.c. preferentially augmented REM sleep and abolished the sleep suppressant effect of morphine.
1 context sentence(design, population, supporting numbers)
Summary · context
The synthetic nonapeptide DSIP was studied in rabbits and cats under normal conditions and under conditions of disturbed sleep.
Report a problemFND-0654896704
05AnimalAnimal study (in vivo)Efficacy outcome
In morphine-dependent mice, DSIP given intravenously or subcutaneously attenuated naloxone-induced withdrawal jumping.
In plain wordsIn morphine-dependent mice, DSIP reduced withdrawal jumping triggered by naloxone.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
DecreaseNaloxone-induced withdrawal jumping
Study
mousen: not reported in source
morphine-dependent mice
Outcome group
Pain · Nervous system and cognition
Studied dose
25.5 micrograms/kg i.v.; above 85 micrograms/kg s.c. · intravenous; subcutaneousAs given in this study (mouse).
Source sentences
Summary
In morphine-dependent mice, 25.5 micrograms X kg-1 i.v. as well as doses beyond 85 micrograms X kg-1 s.c. attenuated naloxone-induced withdrawal jumping.
1 context sentence(design, population, supporting numbers)
Summary · context
In other experiments, the effect of the oligopeptide on withdrawal jumping provoked by naloxone in morphine-dependent mice was studied.
Report a problemFND-0654896705
06AnimalAnimal study (in vivo)Mechanism
In most experimental situations in rabbits, cats and mice, DSIP showed indications of bell-shaped dose-response curves.
In plain wordsIn rabbits, cats and mice, DSIP often showed bell-shaped dose-response curves.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
Not applicableShape of the dose-response curve
Study
rabbit, cat, mousen: not reported in source
in vivo studies
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
In most experimental situations, indications for bell-shaped dose-response curves of DSIP were found.
Report a problemFND-0654896706

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
9 Oct 2026, 18:17 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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