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Study · Non-randomized trial · n = 10 · 1995

4 results

Delta-sleep-inducing peptide does not affect CRH and meal-induced ACTH and cortisol secretion.

Späth-Schwalbe E, Schäfer A, Uthgenannt D, Born J, Fehm HL

Psychoneuroendocrinology1 Jan 1995Cited by 4 (Europe PMC)

PMID7777652 (opens in a new tab)DOI10.1016/0306-4530(94)00050-k (opens in a new tab)PepBankPUB-07777652
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In healthy men, intravenous DSIP did not affect the meal-related midday surge of ACTH.

    In plain wordsIn healthy men, DSIP did not change the rise in ACTH after a meal.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeMeal-related ACTH surge
    Study

    n = 10

    Comparator
    Placebo
    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    4 mg · intravenous infusionAs given in this study (human).

    Source sentences

    Summary
    Meal-related midday surge of ACTH and cortisol was also not affected by DSIP.
    1 context sentence
    Summary · context
    In a second experiment, the influence of DSIP (4 mg, also administered as intravenous infusion) on meal-related ACTH and cortisol secretion was studied in another 10 men.
  2. 02HumanNon-randomized trialEfficacy outcome

    In healthy men, intravenous DSIP did not affect the meal-related midday surge of cortisol.

    In plain wordsIn healthy men, DSIP did not change the rise in cortisol after a meal.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeMeal-related cortisol surge
    Study

    n = 10

    Comparator
    Placebo
    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    4 mg · intravenous infusionAs given in this study (human).

    Source sentences

    Summary
    Meal-related midday surge of ACTH and cortisol was also not affected by DSIP.
    1 context sentence
    Summary · context
    In a second experiment, the influence of DSIP (4 mg, also administered as intravenous infusion) on meal-related ACTH and cortisol secretion was studied in another 10 men.
  3. 03HumanNon-randomized trialEfficacy outcome

    In healthy young men, intravenous DSIP did not change the ACTH response to human CRH compared with placebo.

    In plain wordsIn healthy young men, DSIP did not change the ACTH response to a stimulating hormone compared with placebo.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeACTH response to CRH
    Study

    n = 5

    Comparator
    Placebo
    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    3 and 4 mg total doses · intravenous infusion · from 30 min before to 90 min after CRH injectionAs given in this study (human).

    Source sentences

    Summary
    Responses of ACTH and cortisol were almost identical during and after infusion of DSIP and placebo.
    2 context sentences
    Summary · context
    We examined, first, the influence of DSIP on ACTH and cortisol release following stimulation with human corticotropin-releasing hormone (h-CRH; 1.0 microgram/kg body weight, and 0.5 microgram/kg body weight, respectively) in healthy young men (n = 5 in each condition).
    Summary · context
    DSIP (total doses of 3 and 4 mg, respectively, vs. placebo) was infused intravenously between 30 min prior to and 90 min after CRH injections.
  4. 04HumanNon-randomized trialEfficacy outcome

    In healthy young men, intravenous DSIP did not change the cortisol response to human CRH compared with placebo.

    In plain wordsIn healthy young men, DSIP did not change the cortisol response to a stimulating hormone compared with placebo.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeCortisol response to CRH
    Study

    n = 5

    Comparator
    Placebo
    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    3 and 4 mg total doses · intravenous infusion · from 30 min before to 90 min after CRH injectionAs given in this study (human).

    Source sentences

    Summary
    Responses of ACTH and cortisol were almost identical during and after infusion of DSIP and placebo.
    2 context sentences
    Summary · context
    We examined, first, the influence of DSIP on ACTH and cortisol release following stimulation with human corticotropin-releasing hormone (h-CRH; 1.0 microgram/kg body weight, and 0.5 microgram/kg body weight, respectively) in healthy young men (n = 5 in each condition).
    Summary · context
    DSIP (total doses of 3 and 4 mg, respectively, vs. placebo) was infused intravenously between 30 min prior to and 90 min after CRH injections.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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