Delta sleep-inducing peptide alters bispectral index, the electroencephalogram and heart rate variability when used as an adjunct to isoflurane anaesthesia.

Pomfrett CJ, Dolling S, Anders NR, Glover DG, Bryan A, Pollard BJ

European journal of anaesthesiology1 Feb 2009Cited by 8 (Europe PMC)

PMID19142086DOI10.1097/eja.0b013e32831c8644PepBankPUB-19142086

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. 6 results from people.

01HumanRandomized controlled trialMechanism
In female patients, DSIP significantly altered the symmetry of the EEG between the two cerebral hemispheres.
In plain wordsIn women, DSIP changed how similar the brain waves of the two sides of the brain were.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
Direction not reportedBilateral EEG symmetry
Study
n = 24
Comparator
Saline
Outcome group
Anesthesia depth · Nervous system and cognition
Studied dose
Dose not stated · intravenous bolusAs given in this study (human).
Source sentences
Summary
DSIP also significantly altered bilateral symmetry of EEG.
1 context sentence(design, population, supporting numbers)
Summary · context
Twenty-four female ASA I or II patients gave written, informed consent to a protocol approved by our local research ethics committee. Twelve were randomly assigned as controls to receive saline. The other 12 were randomly allocated to receive one of three intravenous bolus doses of DSIP (Clinalfa) a…
Report a problemFND-1914208606
02HumanRandomized controlled trialSafety outcome
In female patients under isoflurane anaesthesia, DSIP significantly increased heart rate.
In plain wordsIn women under anaesthesia, DSIP raised the heart rate.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
IncreaseHeart rate
Study
n: not reported in source
Comparator
Saline
Outcome group
Heart function · Cardiovascular
Studied dose
25 nmol kg(-1) · intravenous bolusAs given in this study (human).
Source sentences
Summary
DSIP significantly increased heart rate, decreased HRV and, paradoxically, significantly reduced delta rhythm along with reducing burst suppression and increasing BIS at 25 nmol kg(-1) during isoflurane anaesthesia.
1 context sentence(design, population, supporting numbers)
Summary · context
Twenty-four female ASA I or II patients gave written, informed consent to a protocol approved by our local research ethics committee. Twelve were randomly assigned as controls to receive saline. The other 12 were randomly allocated to receive one of three intravenous bolus doses of DSIP (Clinalfa) a…
Report a problemFND-1914208601
03HumanRandomized controlled trialSafety outcome
In female patients under isoflurane anaesthesia, DSIP significantly decreased heart rate variability.
In plain wordsIn women under anaesthesia, DSIP lowered heart rate variability.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
DecreaseHeart rate variability
Study
n: not reported in source
Comparator
Saline
Outcome group
Heart function · Cardiovascular
Studied dose
25 nmol kg(-1) · intravenous bolusAs given in this study (human).
Source sentences
Summary
DSIP significantly increased heart rate, decreased HRV and, paradoxically, significantly reduced delta rhythm along with reducing burst suppression and increasing BIS at 25 nmol kg(-1) during isoflurane anaesthesia.
1 context sentence(design, population, supporting numbers)
Summary · context
Twenty-four female ASA I or II patients gave written, informed consent to a protocol approved by our local research ethics committee. Twelve were randomly assigned as controls to receive saline. The other 12 were randomly allocated to receive one of three intravenous bolus doses of DSIP (Clinalfa) a…
Report a problemFND-1914208602
04HumanRandomized controlled trialMechanism
In female patients under isoflurane anaesthesia, DSIP significantly reduced EEG delta rhythm.
In plain wordsIn women under anaesthesia, DSIP reduced delta brain waves, the opposite of what the researchers expected.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
DecreaseEEG delta rhythm
Study
n: not reported in source
Comparator
Saline
Outcome group
Anesthesia depth · Nervous system and cognition
Studied dose
25 nmol kg(-1) · intravenous bolusAs given in this study (human).
Source sentences
Summary
DSIP significantly increased heart rate, decreased HRV and, paradoxically, significantly reduced delta rhythm along with reducing burst suppression and increasing BIS at 25 nmol kg(-1) during isoflurane anaesthesia.
1 context sentence(design, population, supporting numbers)
Summary · context
Twenty-four female ASA I or II patients gave written, informed consent to a protocol approved by our local research ethics committee. Twelve were randomly assigned as controls to receive saline. The other 12 were randomly allocated to receive one of three intravenous bolus doses of DSIP (Clinalfa) a…
Report a problemFND-1914208603
05HumanRandomized controlled trialMechanism
In female patients under isoflurane anaesthesia, DSIP reduced EEG burst suppression.
In plain wordsIn women under anaesthesia, DSIP reduced burst suppression in brain waves.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
DecreaseEEG burst suppression
Study
n: not reported in source
Comparator
Saline
Outcome group
Anesthesia depth · Nervous system and cognition
Studied dose
25 nmol kg(-1) · intravenous bolusAs given in this study (human).
Source sentences
Summary
DSIP significantly increased heart rate, decreased HRV and, paradoxically, significantly reduced delta rhythm along with reducing burst suppression and increasing BIS at 25 nmol kg(-1) during isoflurane anaesthesia.
1 context sentence(design, population, supporting numbers)
Summary · context
Twenty-four female ASA I or II patients gave written, informed consent to a protocol approved by our local research ethics committee. Twelve were randomly assigned as controls to receive saline. The other 12 were randomly allocated to receive one of three intravenous bolus doses of DSIP (Clinalfa) a…
Report a problemFND-1914208604
06HumanRandomized controlled trialEfficacy outcome
In female patients under isoflurane anaesthesia, DSIP increased the bispectral index, which means lighter anaesthesia.
In plain wordsIn women under anaesthesia, DSIP made the anaesthesia lighter, not deeper, as measured by the bispectral index.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
IncreaseBispectral index (BIS)
Study
n: not reported in source
Comparator
Saline
Outcome group
Anesthesia depth · Nervous system and cognition
Studied dose
25 nmol kg(-1) · intravenous bolusAs given in this study (human).
Source sentences
Summary
DSIP significantly increased heart rate, decreased HRV and, paradoxically, significantly reduced delta rhythm along with reducing burst suppression and increasing BIS at 25 nmol kg(-1) during isoflurane anaesthesia.
2 context sentences(design, population, supporting numbers)
Summary · context
DSIP probably reduced parasympathetic tone and decreased (lightened) the depth of anaesthesia measured using BIS.
Summary · context
Twenty-four female ASA I or II patients gave written, informed consent to a protocol approved by our local research ethics committee. Twelve were randomly assigned as controls to receive saline. The other 12 were randomly allocated to receive one of three intravenous bolus doses of DSIP (Clinalfa) a…
Report a problemFND-1914208605

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
9 Oct 2026, 18:17 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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