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Study · Animal study (in vivo) · mouse · 1982

3 results

Amphetamine-induced locomotor behavior of mice is influenced by DSIP.

Graf M, Zadina JE, Schoenenberger GA

Peptides1 Sept 1982Cited by 11 (Europe PMC)

PMID6897447 (opens in a new tab)DOI10.1016/0196-9781(82)90006-7 (opens in a new tab)PepBankPUB-06897447
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice, DSIP-treated animals generally showed lower locomotor activity after amphetamine than controls.

    In plain wordsIn mice, DSIP-treated animals were generally less active after amphetamine than controls.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseAmphetamine-induced locomotor activity
    Study

    mousen: not reported in source

    mouse in vivo, amphetamine challenge, 22 degrees C
    Comparator
    Controls
    Outcome group
    Exercise and physical function · Nervous system and cognition
    Studied dose
    30 and 120 nmol/kgAs given in this study (mouse).

    Source sentences

    Summary
    In general, DSIP-treated mice showed lower locomotor activity after amphetamine than controls
    1 context sentence
    Summary · context
    However, two different doses of DSIP (30 and 120 nmol/kg) and 3 doses of amphetamine (4, 10, and 15 mg/kg) produced a complex pattern of effects in mice tested at 22 degrees C.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice given 15 mg/kg amphetamine, 30 nmol/kg DSIP produced higher locomotor scores than controls in the first two hours after amphetamine.

    In plain wordsIn mice given a high amphetamine dose, one DSIP dose led to higher activity than in controls in the first two hours.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseLocomotor activity after 15 mg/kg amphetamine, DSIP 30 nmol/kg
    Study

    mousen: not reported in source

    mouse in vivo, amphetamine challenge, 22 degrees C
    Comparator
    Controls
    Outcome group
    Exercise and physical function · Nervous system and cognition
    Studied dose
    30 nmol/kgAs given in this study (mouse).

    Source sentences

    Summary
    In general, DSIP-treated mice showed lower locomotor activity after amphetamine than controls, but under two conditions, both using 15 mg/kg amphetamine, DSIP produced higher scores; this occurred in the first two hours after amphetamine for the 30 nmol/kg DSIP group and in the third hour for mice g…
    1 context sentence
    Summary · context
    However, two different doses of DSIP (30 and 120 nmol/kg) and 3 doses of amphetamine (4, 10, and 15 mg/kg) produced a complex pattern of effects in mice tested at 22 degrees C.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice given 15 mg/kg amphetamine, 120 nmol/kg DSIP produced higher locomotor scores than controls in the third hour.

    In plain wordsIn mice given a high amphetamine dose, a higher DSIP dose led to higher activity than in controls in the third hour.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseLocomotor activity after 15 mg/kg amphetamine, DSIP 120 nmol/kg
    Study

    mousen: not reported in source

    mouse in vivo, amphetamine challenge, 22 degrees C
    Comparator
    Controls
    Outcome group
    Exercise and physical function · Nervous system and cognition
    Studied dose
    120 nmol/kgAs given in this study (mouse).

    Source sentences

    Summary
    In general, DSIP-treated mice showed lower locomotor activity after amphetamine than controls, but under two conditions, both using 15 mg/kg amphetamine, DSIP produced higher scores; this occurred in the first two hours after amphetamine for the 30 nmol/kg DSIP group and in the third hour for mice g…
    1 context sentence
    Summary · context
    However, two different doses of DSIP (30 and 120 nmol/kg) and 3 doses of amphetamine (4, 10, and 15 mg/kg) produced a complex pattern of effects in mice tested at 22 degrees C.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

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