The effect of subcutaneous administration of delta sleep-inducing peptide (DSIP) on some parameters of sleep in the cat.

Susić V

Physiology & behavior1 Jan 1987Cited by 3 (Europe PMC)

PMID3671519DOI10.1016/0031-9384(87)90098-9PepBankPUB-03671519

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In cats, subcutaneous DSIP significantly increased deep slow-wave sleep.
In plain wordsIn cats, DSIP injected under the skin increased deep slow-wave sleep.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
IncreaseDeep slow-wave sleep (DSWS)
Study
catn = 8
Comparator
Ringer injection
Outcome group
Sleep · Sleep
Studied dose
120 nmol/kg · subcutaneousAs given in this study (cat).
Source sentences
Summary
Delta sleep inducing peptide (DSIP) significantly increases deep-slow-wave sleep (DSWS) of cats after subcutaneous (SC) injection.
1 context sentence(design, population, supporting numbers)
Summary · context
Cats (n = 8) were SC injected with DSIP (120 nmol.kg-1) prior to polygraphic recording of EEG combined with electro-oculography, EOG) and electromyography (EMG) for 8 hours.
Report a problemFND-0367151901
02AnimalAnimal study (in vivo)Efficacy outcome
In cats, subcutaneous DSIP significantly increased slow waves (delta sleep) in the sleep EEG.
In plain wordsIn cats, DSIP injected under the skin increased slow brain waves typical of deep sleep.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
IncreaseSlow waves (delta sleep) in sleep EEG
Study
catn = 8
Comparator
Ringer injection
Outcome group
Sleep · Sleep
Studied dose
120 nmol/kg · subcutaneousAs given in this study (cat).
Source sentences
Summary
DSIP was found to significantly increase slow-waves (delta sleep) in the sleep EEG.
1 context sentence(design, population, supporting numbers)
Summary · context
Cats (n = 8) were SC injected with DSIP (120 nmol.kg-1) prior to polygraphic recording of EEG combined with electro-oculography, EOG) and electromyography (EMG) for 8 hours.
Report a problemFND-0367151902
03AnimalAnimal study (in vivo)Efficacy outcome
In cats, DSIP showed a tendency to reduce waking time, but the difference from control was not statistically significant.
In plain wordsIn cats, DSIP did not significantly change waking time compared with a control injection.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
No significant changeWaking time
Study
catn = 8
Comparator
Ringer injection
Outcome group
Sleep · Sleep
Studied dose
120 nmol/kg · subcutaneousAs given in this study (cat).
Source sentences
Summary
There was a tendency to reduced waking time and a prolongation of slow wave sleep time, and a shortening of sleep onset and REM sleep latencies but the differences from control (Ringer injection) were not statistically significant.
1 context sentence(design, population, supporting numbers)
Summary · context
Cats (n = 8) were SC injected with DSIP (120 nmol.kg-1) prior to polygraphic recording of EEG combined with electro-oculography, EOG) and electromyography (EMG) for 8 hours.
Report a problemFND-0367151903
04AnimalAnimal study (in vivo)Efficacy outcome
In cats, the prolongation of slow wave sleep time after DSIP was not statistically significant versus control.
In plain wordsIn cats, DSIP did not significantly lengthen slow wave sleep compared with a control injection.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
No significant changeSlow wave sleep time
Study
catn = 8
Comparator
Ringer injection
Outcome group
Sleep · Sleep
Studied dose
120 nmol/kg · subcutaneousAs given in this study (cat).
Source sentences
Summary
There was a tendency to reduced waking time and a prolongation of slow wave sleep time, and a shortening of sleep onset and REM sleep latencies but the differences from control (Ringer injection) were not statistically significant.
1 context sentence(design, population, supporting numbers)
Summary · context
Cats (n = 8) were SC injected with DSIP (120 nmol.kg-1) prior to polygraphic recording of EEG combined with electro-oculography, EOG) and electromyography (EMG) for 8 hours.
Report a problemFND-0367151904
05AnimalAnimal study (in vivo)Efficacy outcome
In cats, the shortening of sleep onset and REM sleep latencies after DSIP was not statistically significant versus control.
In plain wordsIn cats, DSIP did not significantly shorten the time to fall asleep or to start REM sleep compared with a control injection.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
No significant changeSleep onset and REM sleep latencies
Study
catn = 8
Comparator
Ringer injection
Outcome group
Sleep · Sleep
Studied dose
120 nmol/kg · subcutaneousAs given in this study (cat).
Source sentences
Summary
There was a tendency to reduced waking time and a prolongation of slow wave sleep time, and a shortening of sleep onset and REM sleep latencies but the differences from control (Ringer injection) were not statistically significant.
1 context sentence(design, population, supporting numbers)
Summary · context
Cats (n = 8) were SC injected with DSIP (120 nmol.kg-1) prior to polygraphic recording of EEG combined with electro-oculography, EOG) and electromyography (EMG) for 8 hours.
Report a problemFND-0367151905
06AnimalAnimal study (in vivo)Efficacy outcome
In cats, DSIP did not change the amount of REM sleep.
In plain wordsIn cats, DSIP did not change the amount of REM sleep.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
No significant changeREM sleep amount
Study
catn = 8
Comparator
Ringer injection
Outcome group
Sleep · Sleep
Studied dose
120 nmol/kg · subcutaneousAs given in this study (cat).
Source sentences
Summary
There was no change in the amount of REM sleep.
1 context sentence(design, population, supporting numbers)
Summary · context
Cats (n = 8) were SC injected with DSIP (120 nmol.kg-1) prior to polygraphic recording of EEG combined with electro-oculography, EOG) and electromyography (EMG) for 8 hours.
Report a problemFND-0367151906

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 09:43 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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