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Study · Animal study (in vivo) · rat · 2018

9 results

Phosphorylated delta sleep inducing peptide restores spatial memory and p-CREB expression by improving sleep architecture at high altitude.

Roy K, Chauhan G, Kumari P, Wadhwa M, Alam S, Ray K, Panjwani U, Kishore K

Life sciences11 Aug 2018Cited by 12 (Europe PMC)

PMID30107169 (opens in a new tab)DOI10.1016/j.lfs.2018.08.026 (opens in a new tab)PepBankPUB-30107169
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats exposed to simulated high altitude, daily p-DSIP injection enhanced non-REM sleep.

    In plain wordsIn rats at simulated high altitude, p-DSIP increased non-REM sleep.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseNon-REM sleep
    Study

    ratn: not reported in source

    Rats exposed to chronic hypobaric hypoxia at 7620 m
    Outcome group
    Sleep · Sleep
    Studied dose
    10 μg/Kg bw · intraperitoneal · daily during chronic hypobaric hypoxia exposureAs given in this study (rat).

    Source sentences

    Summary
    p-DSIP injection daily in circadian active period (18.30 h) during chronic HH enhanced non rapid eye movement sleep, rapid eye movement sleep as well as improved MWM performance of rats
    1 context sentence
    Summary · context
    Morris water maze (MWM) trained rats were exposed to HH at 7620 m. p-DSIP was injected intra-peritoneally (10 μg/Kg bw) during HH exposure as an intervention against sleep alteration.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats exposed to simulated high altitude, daily p-DSIP injection enhanced rapid eye movement sleep.

    In plain wordsIn rats at simulated high altitude, p-DSIP increased REM sleep.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseREM sleep
    Study

    ratn: not reported in source

    Rats exposed to chronic hypobaric hypoxia at 7620 m
    Outcome group
    Sleep · Sleep
    Studied dose
    10 μg/Kg bw · intraperitoneal · daily during chronic hypobaric hypoxia exposureAs given in this study (rat).

    Source sentences

    Summary
    p-DSIP injection daily in circadian active period (18.30 h) during chronic HH enhanced non rapid eye movement sleep, rapid eye movement sleep as well as improved MWM performance of rats
    1 context sentence
    Summary · context
    Morris water maze (MWM) trained rats were exposed to HH at 7620 m. p-DSIP was injected intra-peritoneally (10 μg/Kg bw) during HH exposure as an intervention against sleep alteration.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats exposed to simulated high altitude, daily p-DSIP injection improved Morris water maze performance.

    In plain wordsIn rats at simulated high altitude, p-DSIP improved spatial memory in a maze test.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseMorris water maze performance
    Study

    ratn: not reported in source

    Rats exposed to chronic hypobaric hypoxia at 7620 m
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    10 μg/Kg bw · intraperitoneal · daily during chronic hypobaric hypoxia exposureAs given in this study (rat).

    Source sentences

    Summary
    p-DSIP injection daily in circadian active period (18.30 h) during chronic HH enhanced non rapid eye movement sleep, rapid eye movement sleep as well as improved MWM performance of rats
    1 context sentence
    Summary · context
    Morris water maze (MWM) trained rats were exposed to HH at 7620 m. p-DSIP was injected intra-peritoneally (10 μg/Kg bw) during HH exposure as an intervention against sleep alteration.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In rats exposed to simulated high altitude, p-DSIP treatment lowered monoamine levels.

    In plain wordsIn rats at simulated high altitude, p-DSIP lowered brain monoamine levels.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseBrain stem and hypothalamus monoamine levels
    Study

    ratn: not reported in source

    Rats exposed to chronic hypobaric hypoxia at 7620 m
    Outcome group
    Neurotransmitters and neurotrophic factors · Nervous system and cognition
    Studied dose
    10 μg/Kg bw · intraperitoneal · daily during chronic hypobaric hypoxia exposureAs given in this study (rat).

    Source sentences

    Summary
    p-DSIP treatment showed lower monoamine level and tyrosine hydroxylase (TH) expression
    1 context sentence
    Summary · context
    Morris water maze (MWM) trained rats were exposed to HH at 7620 m. p-DSIP was injected intra-peritoneally (10 μg/Kg bw) during HH exposure as an intervention against sleep alteration.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In rats exposed to simulated high altitude, p-DSIP treatment lowered tyrosine hydroxylase expression.

    In plain wordsIn rats at simulated high altitude, p-DSIP lowered levels of an enzyme that makes brain monoamines.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseTyrosine hydroxylase expression
    Study

    ratn: not reported in source

    Rats exposed to chronic hypobaric hypoxia at 7620 m
    Outcome group
    Neurotransmitters and neurotrophic factors · Nervous system and cognition
    Studied dose
    10 μg/Kg bw · intraperitoneal · daily during chronic hypobaric hypoxia exposureAs given in this study (rat).

    Source sentences

    Summary
    p-DSIP treatment showed lower monoamine level and tyrosine hydroxylase (TH) expression
    1 context sentence
    Summary · context
    Morris water maze (MWM) trained rats were exposed to HH at 7620 m. p-DSIP was injected intra-peritoneally (10 μg/Kg bw) during HH exposure as an intervention against sleep alteration.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In rats exposed to simulated high altitude, p-DSIP treatment increased monoamine oxidase A expression.

    In plain wordsIn rats at simulated high altitude, p-DSIP raised levels of an enzyme that breaks down brain monoamines.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseMonoamine oxidase A expression
    Study

    ratn: not reported in source

    Rats exposed to chronic hypobaric hypoxia at 7620 m
    Outcome group
    Neurotransmitters and neurotrophic factors · Nervous system and cognition
    Studied dose
    10 μg/Kg bw · intraperitoneal · daily during chronic hypobaric hypoxia exposureAs given in this study (rat).

    Source sentences

    Summary
    p-DSIP treatment showed lower monoamine level and tyrosine hydroxylase (TH) expression and increased monoamine oxidase A (MAO A), glutamic acid decarboxylase (GAD) and Choline acetyltransferase (ChAT) expression.
    1 context sentence
    Summary · context
    Morris water maze (MWM) trained rats were exposed to HH at 7620 m. p-DSIP was injected intra-peritoneally (10 μg/Kg bw) during HH exposure as an intervention against sleep alteration.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In rats exposed to simulated high altitude, p-DSIP treatment increased glutamic acid decarboxylase expression.

    In plain wordsIn rats at simulated high altitude, p-DSIP raised levels of an enzyme that makes the brain messenger GABA.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseGlutamic acid decarboxylase expression
    Study

    ratn: not reported in source

    Rats exposed to chronic hypobaric hypoxia at 7620 m
    Outcome group
    Neurotransmitters and neurotrophic factors · Nervous system and cognition
    Studied dose
    10 μg/Kg bw · intraperitoneal · daily during chronic hypobaric hypoxia exposureAs given in this study (rat).

    Source sentences

    Summary
    p-DSIP treatment showed lower monoamine level and tyrosine hydroxylase (TH) expression and increased monoamine oxidase A (MAO A), glutamic acid decarboxylase (GAD) and Choline acetyltransferase (ChAT) expression.
    1 context sentence
    Summary · context
    Morris water maze (MWM) trained rats were exposed to HH at 7620 m. p-DSIP was injected intra-peritoneally (10 μg/Kg bw) during HH exposure as an intervention against sleep alteration.
  8. 08AnimalAnimal study (in vivo)Mechanism

    In rats exposed to simulated high altitude, p-DSIP treatment increased choline acetyltransferase expression.

    In plain wordsIn rats at simulated high altitude, p-DSIP raised levels of an enzyme that makes acetylcholine.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseCholine acetyltransferase expression
    Study

    ratn: not reported in source

    Rats exposed to chronic hypobaric hypoxia at 7620 m
    Outcome group
    Neurotransmitters and neurotrophic factors · Nervous system and cognition
    Studied dose
    10 μg/Kg bw · intraperitoneal · daily during chronic hypobaric hypoxia exposureAs given in this study (rat).

    Source sentences

    Summary
    p-DSIP treatment showed lower monoamine level and tyrosine hydroxylase (TH) expression and increased monoamine oxidase A (MAO A), glutamic acid decarboxylase (GAD) and Choline acetyltransferase (ChAT) expression.
    1 context sentence
    Summary · context
    Morris water maze (MWM) trained rats were exposed to HH at 7620 m. p-DSIP was injected intra-peritoneally (10 μg/Kg bw) during HH exposure as an intervention against sleep alteration.
  9. 09AnimalAnimal study (in vivo)Mechanism

    In rats given p-DSIP at simulated high altitude, naloxone, a mu opioid receptor antagonist, decreased hippocampal CREB and p-CREB and altered navigational memory, suggesting it suppressed the sleep-inducing effect of p-DSIP.

    In plain wordsIn rats at simulated high altitude, an opioid blocker lowered memory-related proteins and changed maze memory, which hints that it blocked the effect of p-DSIP.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Not applicableHippocampal CREB and p-CREB with naloxone
    Study

    ratn: not reported in source

    Rats exposed to chronic hypobaric hypoxia at 7620 m
    Outcome group
    Neurotransmitters and neurotrophic factors · Nervous system and cognition
    Studied dose
    10 μg/Kg bw · intraperitoneal · daily during chronic hypobaric hypoxia exposureAs given in this study (rat).

    Source sentences

    Summary
    Further, naloxone altered navigational memory by decreasing the CREB and p-CREB level in hippocampus suggesting suppression of sleep inducing effect of p-DSIP.
    1 context sentence
    Summary · context
    Naloxone (1 mg/kg bw), a μ opioid receptor antagonist of sleep inducing effect of DSIP was also studied.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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