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Study · Animal study (in vivo) · dog, monkey and rat · 1984

7 results

Development of an enzyme immunoassay for delta sleep-inducing peptide (DSIP) and its use in the determination of the metabolic clearance rate of DSIP administered to dogs.

Kato N, Honda Y, Ebihara S, Naruse H, Takahashi Y

Neuroendocrinology1 Jul 1984Cited by 14 (Europe PMC)

PMID6379493 (opens in a new tab)DOI10.1159/000123952 (opens in a new tab)PepBankPUB-06379493
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Pharmacokinetics

    In anesthetized dogs, DSIP given intravenously was cleared rapidly, with a mean metabolic clearance rate of 30.7 ml/kg.min.

    In plain wordsIn dogs, DSIP left the blood quickly after an injection into a vein.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Not applicableMetabolic clearance rate of DSIP
    Study

    dogn = 4

    anesthetized dogs
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    1 or 2 mg · intravenousAs given in this study (dog).

    Measurements

    Metabolic clearance rate
    30.7 ml/kg.min
    dogs

    Source sentences

    Summary
    DSIP was found to have a rapid disappearance with a mean metabolic clearance rate of 30.7 +/- 2.5 ml/kg . min and a mean half-life of 4.0 +/- 0.7 min in the dogs.
    1 context sentence
    Summary · context
    1 or 2 mg of DSIP was injected intravenously into 4 anesthetized dogs and blood was taken at 5-min intervals.
  2. 02AnimalAnimal study (in vivo)Pharmacokinetics

    In anesthetized dogs, the mean plasma half-life of intravenous DSIP was 4.0 min.

    In plain wordsIn dogs, DSIP had a very short half-life in the blood, about 4 minutes.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Not applicableBiological half-life of DSIP in dogs
    Study

    dogn = 4

    anesthetized dogs
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    1 or 2 mg · intravenousAs given in this study (dog).

    Measurements

    Half-life
    4 min
    dogs

    Source sentences

    Summary
    DSIP was found to have a rapid disappearance with a mean metabolic clearance rate of 30.7 +/- 2.5 ml/kg . min and a mean half-life of 4.0 +/- 0.7 min in the dogs.
    1 context sentence
    Summary · context
    1 or 2 mg of DSIP was injected intravenously into 4 anesthetized dogs and blood was taken at 5-min intervals.
  3. 03AnimalAnimal study (in vivo)Pharmacokinetics

    In 3 rats, DSIP cleared rapidly from plasma in vivo with a half-life of 2.0 min.

    In plain wordsIn rats, DSIP left the blood quickly, with a half-life of about 2 minutes.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Not applicablePlasma half-life of DSIP in rats
    Study

    ratn = 3

    rats
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated

    Measurements

    Half-life
    2 min
    rats

    Source sentences

    Summary
    Additional measurement of the metabolic parameters in a monkey and 3 rats treated similarly revealed a rapid in vivo clearance of DSIP from plasma with a half-life of 2.9 and 2.0 +/- 0.54 min, respectively.
  4. 04AnimalAnimal study (in vivo)Pharmacokinetics

    In one monkey, DSIP cleared rapidly from plasma in vivo with a half-life of 2.9 min.

    In plain wordsIn one monkey, DSIP left the blood quickly, with a half-life of 2.9 minutes.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Not applicablePlasma half-life of DSIP in monkey
    Study

    monkeyn = 1

    monkey
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated

    Measurements

    Half-life
    2.9 min
    monkey

    Source sentences

    Summary
    Additional measurement of the metabolic parameters in a monkey and 3 rats treated similarly revealed a rapid in vivo clearance of DSIP from plasma with a half-life of 2.9 and 2.0 +/- 0.54 min, respectively.

Studies that did not test the peptide alone3

In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Delta sleep-inducing peptide (DSIP).

  1. 05LabNot a test of Delta sleep-inducing peptide (DSIP) aloneIn vitro (cell-free)Other

    The enzyme immunoassay for DSIP had a sensitivity of approximately 30 pg/ml.

    In plain wordsIn lab tests, the new assay could detect DSIP at about 30 pg/ml.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Not applicableEIA sensitivity
    Study

    n: not reported in source

    enzyme immunoassay
    Outcome group
    Pharmacokinetics · Pharmacology

    Measurements

    Assay sensitivity
    ≈ 30 pg/ml
    EIA

    Source sentences

    Summary
    The assay sensitivity was approximately 30 pg/ml.

    In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).

  2. 06LabNot a test of Delta sleep-inducing peptide (DSIP) aloneIn vitro (cell-free)Other

    Antisera raised in rabbits against DSIP conjugated to bovine serum albumin were specific for the C-terminus of the peptide.

    In plain wordsIn lab tests, the antibodies against DSIP recognised the C-terminal end of the peptide.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Not applicableAntiserum specificity
    Study

    n: not reported in source

    enzyme immunoassay
    Outcome group
    Pharmacokinetics · Pharmacology

    Source sentences

    Summary
    Antisera to DSIP conjugated to bovine serum albumin were raised in rabbits and proved to be specific for the C-terminus of the peptide.

    In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).

  3. 07LabNot a test of Delta sleep-inducing peptide (DSIP) aloneIn vitro (cell-free)Other

    Unextracted plasma gave parallel displacement curves to the standards in the DSIP enzyme immunoassay.

    In plain wordsIn lab tests, the assay worked directly on plasma and gave curves parallel to the standards.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Not applicableAssay behaviour in unextracted plasma
    Study

    n: not reported in source

    enzyme immunoassay
    Outcome group
    Pharmacokinetics · Pharmacology

    Source sentences

    Summary
    Unextracted plasma was subjected to the EIA directly and showed parallel displacement curves to the standards.

    In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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