DSIP-Like KND Peptide Reduces Brain Infarction in C57Bl/6 and Reduces Myocardial Infarction in SD Rats When Administered during Reperfusion.

Tukhovskaya EA, Shaykhutdinova ER, Ismailova AM, Slashcheva GA, Prudchenko IA, Mikhaleva II, Khokhlova ON, Murashev AN, Ivanov VT

Biomedicines9 Apr 2021Cited by 2 (Europe PMC)

PMID33918965PMCIDPMC8069497DOI10.3390/biomedicines9040407PepBankPUB-33918965

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Summary

A structural analogue of the DSIP, peptide KND, previously showed higher detoxification efficacy upon administration of the cytotoxic drug cisplatin, compared to DSIP. DSIP and KND were investigated using the model of acute myocardial infarction in male SD rats and the model of acute focal stroke in C57Bl/6 mice. A significant decrease in the myocardial infarction area was registered in KND-treated animals relative to saline-treated control animals (19.1 ± 7.3% versus 42.1 ± 9.2%). The brain infarction volume was significantly lower in animals intranasally treated with KND compared to the control saline-treated animals (7.4 ± 3.5% versus 12.2 ± 5.6%). Injection of KND in the first minute of reperfusion in the models of myocardial infarction and cerebral stroke reduced infarction of these organs, indicating a pronounced cardioprotective and neuroprotective effect of KND and potentiality for the treatment of ischemia-reperfusion injuries after transient ischemic attacks on the heart and brain, when administered during the reperfusion period. A preliminary pilot study using the model of myocardial infarction with the administration of DSIP during occlusion, and the model of cerebral stroke with the administration of KND during occlusion, resulted in 100% mortality in animals. Thus, in the case of ischemia-reperfusion injuries of the myocardium and the brain, use of these peptides is only possible during reperfusion.

CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study1

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01AnimalAnimal study (in vivo)Safety outcome
In a preliminary pilot in rats with myocardial infarction, DSIP given during occlusion was followed by 100% mortality.
In plain wordsIn a small pilot in rats with induced heart attack, all animals given DSIP during the blockage died.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
Not applicableMortality with DSIP given during occlusion (pilot)
Study
ratn: not reported in source
Acute myocardial infarction model
Outcome group
Mortality · Cardiovascular
Studied dose
Dose not stated
Measurements
Mortality
100%
DSIP during occlusion, pilot
Source sentences
Summary
A preliminary pilot study using the model of myocardial infarction with the administration of DSIP during occlusion, and the model of cerebral stroke with the administration of KND during occlusion, resulted in 100% mortality in animals.
1 context sentence(design, population, supporting numbers)
Summary · context
DSIP and KND were investigated using the model of acute myocardial infarction in male SD rats and the model of acute focal stroke in C57Bl/6 mice.
Show in the study text Report a problemFND-3391896501

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Version history

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Version 2Current
10 Oct 2026, 08:55 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

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