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Study · Animal study (in vivo) · rat · 1987

4 results

Delta sleep-inducing peptide (DSIP) stimulates LH release in steroid-primed ovariectomized rats.

Sahu A, Kalra SP

Life sciences1 Mar 1987Cited by 11 (Europe PMC)

PMID3550343 (opens in a new tab)DOI10.1016/0024-3205(87)90239-6 (opens in a new tab)PepBankPUB-03550343
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized rats, intraventricular DSIP (2 or 10 micrograms) did not affect LH release.

    In plain wordsIn rats without ovaries, DSIP given into the brain did not change luteinizing hormone release.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeLH release in ovariectomized rats
    Study

    ratn: not reported in source

    Ovariectomized rats
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    2 or 10 micrograms · intraventricularAs given in this study (rat).

    Source sentences

    Summary
    While intraventricular administration of DSIP (2 or 10 micrograms) failed to affect LH release
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In estrogen and progesterone-primed ovariectomized rats, intraventricular DSIP (2 or 10; 15 or 30 micrograms) promptly stimulated LH release.

    In plain wordsIn hormone-primed rats without ovaries, DSIP given into the brain quickly raised luteinizing hormone release.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseLH release in steroid-primed ovariectomized rats
    Study

    ratn: not reported in source

    Ovariectomized estrogen, progesterone-primed rats
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    2-30 micrograms · intraventricularAs given in this study (rat).

    Source sentences

    Summary
    in two separate experiments DSIP (2 or 10; 15 or 30 micrograms) promptly stimulated LH release in ovariectomized estrogen, progesterone-primed rats.
  3. 03LabEx vivo tissueEfficacy outcome

    In hemipituitaries from steroid-primed rats, DSIP had no effect on basal in vitro LH release.

    In plain wordsIn rat pituitary tissue in a dish, DSIP did not change basal luteinizing hormone release.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeBasal in vitro LH release from hemipituitaries
    Study

    ratn: not reported in source

    Hemipituitaries from ovarian steroid-primed rats
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    10(-8) or 10(-6)MAs given in this study (rat).

    Source sentences

    Summary
    However, DSIP (10(-8) or 10(-6)M) had no effect on either basal or luteinizing hormone-releasing hormone-induced in vitro LH release from the hemipituitaries of ovarian steroid-primed rats.
  4. 04LabEx vivo tissueEfficacy outcome

    In hemipituitaries from steroid-primed rats, DSIP had no effect on LHRH-induced in vitro LH release.

    In plain wordsIn rat pituitary tissue in a dish, DSIP did not change luteinizing hormone release caused by LHRH.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeLHRH-induced in vitro LH release from hemipituitaries
    Study

    ratn: not reported in source

    Hemipituitaries from ovarian steroid-primed rats
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    10(-8) or 10(-6)MAs given in this study (rat).

    Source sentences

    Summary
    However, DSIP (10(-8) or 10(-6)M) had no effect on either basal or luteinizing hormone-releasing hormone-induced in vitro LH release from the hemipituitaries of ovarian steroid-primed rats.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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