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Study · Animal study (in vivo) · rat · 2012

3 results

Effect of delta sleep-inducing peptide on oxidative modification of proteins in rat tissues and blood during physiological aging.

Bondarenko TI, Sorokina IA, Mayboroda EA, Durkanaeva OA, Kutilin DS, Mikhaleva II

Bulletin of experimental biology and medicine1 Jul 2012Cited by 3 (Europe PMC)

PMID22866315 (opens in a new tab)DOI10.1007/s10517-012-1719-3 (opens in a new tab)PepBankPUB-22866315
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats of different ages, subcutaneous DSIP (100 μg/kg, monthly 5-day courses) protected proteins in the studied tissues from oxidation, with tissue-specific effects.

    In plain wordsIn rats of different ages, DSIP protected tissue proteins from oxidation, and the effect differed between tissues.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseOxidative modification of proteins in tissues and blood
    Study

    ratn: not reported in source

    Outcome group
    Aging markers · Aging and longevity
    Studied dose
    100 μg/kg · subcutaneous · monthly 5-day coursesAs given in this study (rat).

    Source sentences

    Summary
    Exogenous delta sleep-inducing peptide injected subcutaneously to rats of different age in a dose of 100 μg/kg by monthly 5-day courses protected proteins of the studied tissues from oxidation; its effect was tissue-specific.
    1 context sentence
    Summary · context
    Accumulation of oxidized proteins (evaluated by the levels of carbonyl and SH groups) in tissues of 2-24-month-old rats (spleen>myocardium>testicles>liver>skeletal muscles) has been demonstrated.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In aging rats, DSIP prevented nonenzymatic glycosylation of hemoglobin and showed a hypoglycemic effect.

    In plain wordsIn aging rats, DSIP prevented sugar attachment to hemoglobin and showed a blood sugar lowering effect.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseNonenzymatic glycosylation of hemoglobin
    Study

    ratn: not reported in source

    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    100 μg/kg · subcutaneous · monthly 5-day coursesAs given in this study (rat).

    Source sentences

    Summary
    Delta sleep-inducing peptide exhibited a hypoglycemic effect: it prevented nonenzymatic glycosylation of hemoglobin
    2 context sentences
    Summary · context
    Exogenous delta sleep-inducing peptide injected subcutaneously to rats of different age in a dose of 100 μg/kg by monthly 5-day courses protected proteins of the studied tissues from oxidation; its effect was tissue-specific.
    Summary · context
    Accumulation of oxidized proteins (evaluated by the levels of carbonyl and SH groups) in tissues of 2-24-month-old rats (spleen>myocardium>testicles>liver>skeletal muscles) has been demonstrated.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In aging rats, DSIP reduced the level of defective protein molecules.

    In plain wordsIn aging rats, DSIP lowered the level of defective protein molecules.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseDefective protein molecules during aging
    Study

    ratn: not reported in source

    Outcome group
    Aging markers · Aging and longevity
    Studied dose
    100 μg/kg · subcutaneous · monthly 5-day coursesAs given in this study (rat).

    Source sentences

    Summary
    and reduced the level of defective protein molecules during aging.
    2 context sentences
    Summary · context
    Exogenous delta sleep-inducing peptide injected subcutaneously to rats of different age in a dose of 100 μg/kg by monthly 5-day courses protected proteins of the studied tissues from oxidation; its effect was tissue-specific.
    Summary · context
    Accumulation of oxidized proteins (evaluated by the levels of carbonyl and SH groups) in tissues of 2-24-month-old rats (spleen>myocardium>testicles>liver>skeletal muscles) has been demonstrated.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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