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Study · Animal study (in vivo) · dog and rat · 1984

3 results

Evidence that [125I]N-Tyr-delta sleep-inducing peptide crosses the blood-brain barrier by a non-competitive mechanism.

Banks WA, Kastin AJ, Coy DH

Brain research1 Jun 1984Cited by 43 (Europe PMC)

PMID6547363 (opens in a new tab)DOI10.1016/0006-8993(84)91088-6 (opens in a new tab)PepBankPUB-06547363
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In rats, neither DSIP nor several analogs inhibited the passage of radioactive N-Tyr-DSIP across the blood-brain barrier.

    In plain wordsIn rats, unlabelled DSIP and analogs did not block radioactive DSIP from crossing into the brain.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeCompetitive inhibition of tracer passage across the blood-brain barrier
    Study

    ratn: not reported in source

    rat blood-brain barrier
    Comparator
    Unlabelled DSIP and analogs
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Neither DSIP nor several analogs, including non-radioactive [127I]N-Tyr-DSIP, injected by the jugular vein or carotid artery, inhibited passage of radioactive [125I]N-Tyr-DSIP across the rat BBB.
    1 context sentence
    Summary · context
    New experiments were conducted to determine if this crossing was competitive.
  2. 02AnimalAnimal study (in vivo)Pharmacokinetics

    In rats, column chromatography showed the radioactivity in brain was intact N-Tyr-DSIP, and competitors did not interfere with its degradation or binding.

    In plain wordsIn rats, the radioactivity found in the brain was intact DSIP, and competing substances did not change its breakdown or binding.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Not applicableIntegrity of tracer in brain
    Study

    ratn: not reported in source

    rat brain samples
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Column chromatography of brain samples confirmed that the radioactivity in the brain represented intact [125I]N-Tyr-DSIP and that the non-radioactive competing materials did not interfere with the degradation or binding of [125I]N-Tyr-DSIP.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In dogs, N-Tyr-DSIP did not inhibit the appearance of radioactive N-Tyr-DSIP in the CSF.

    In plain wordsIn dogs, unlabelled N-Tyr-DSIP did not block radioactive DSIP from appearing in the spinal fluid.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeCompetitive inhibition of tracer appearance in CSF
    Study

    dogn: not reported in source

    dog blood-CSF barrier
    Comparator
    N-Tyr-DSIP
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In addition, N-Tyr-DSIP was unable to inhibit the appearance of radioactive [125I]N-Tyr-DSIP in the CSF of dogs.
    1 context sentence
    Summary · context
    New experiments were conducted to determine if this crossing was competitive.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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