[Features of regulating delta sleep-inducing peptide by free radical processes in tissue and erythrocyte membranes in intact animals and under stress].

Shustanova TA, Bondarenko TI, Miliutina NP, Mikhaleva II

Uspekhi fiziologicheskikh nauk1 Jan 2003Cited by 1 (Europe PMC)

PMID12635477PepBankPUB-12635477

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Mechanism
In intact rats and in rats under cold stress, exogenous DSIP increased antioxidant system activity in brain, liver and blood.
In plain wordsIn rats, DSIP raised antioxidant activity in brain, liver and blood, with and without cold stress.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
IncreaseAntioxidant system activity in brain, liver and blood
Study
ratn: not reported in source
Outcome group
Oxidative stress · Whole body
Studied dose
Dose not stated
Source sentences
Summary
Exogenous DSIP increases the antioxidant system activity in tissues of brain, liver and blood in standard conditions and under cold stress.
1 context sentence(design, population, supporting numbers)
Summary · context
In activity the comparative analysis of metabolic effects delta--sleep inducing peptide (DSIP) in tissues and erythrocytes of intact rats and under cold stress is conducted.
Report a problemFND-1263547701
02AnimalAnimal study (in vivo)Mechanism
In rats, the anti-stress effect of DSIP was directed at an increase of endogenous enzymatic antioxidant system activity, especially glutathione peroxidase activity.
In plain wordsIn rats, DSIP raised the activity of the body's own antioxidant enzymes, mainly glutathione peroxidase.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
IncreaseEndogenous enzymatic antioxidant activity, especially glutathione peroxidase
Study
ratn: not reported in source
Outcome group
Oxidative stress · Whole body
Studied dose
Dose not stated
Source sentences
Summary
The anti-stress effect of DSIP is directed as on increase of power endogenic enzymatic antioxidant system activity, specially glutathione peroxidase activity, and not enzymatic of antioxidant protection.
1 context sentence(design, population, supporting numbers)
Summary · context
In activity the comparative analysis of metabolic effects delta--sleep inducing peptide (DSIP) in tissues and erythrocytes of intact rats and under cold stress is conducted.
Report a problemFND-1263547702
03AnimalAnimal study (in vivo)Mechanism
In intact rats, DSIP boosted myeloperoxidase activity in blood neutrophils.
In plain wordsIn healthy rats, DSIP raised myeloperoxidase activity in blood neutrophils.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
IncreaseMyeloperoxidase activity in blood neutrophils (intact rats)
Study
ratn: not reported in source
Outcome group
Oxidative stress · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
for intact animal boosts the myeloperoxidase activity in blood neutrophils
1 context sentence(design, population, supporting numbers)
Summary · context
In activity the comparative analysis of metabolic effects delta--sleep inducing peptide (DSIP) in tissues and erythrocytes of intact rats and under cold stress is conducted.
Report a problemFND-1263547703
04AnimalAnimal study (in vivo)Mechanism
In intact rats, DSIP had no essential influence on xanthine oxidase activity in brain and liver.
In plain wordsIn healthy rats, DSIP did not change xanthine oxidase activity in brain and liver.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
No significant changeXanthine oxidase activity in brain and liver (intact rats)
Study
ratn: not reported in source
Outcome group
Oxidative stress · Whole body
Studied dose
Dose not stated
Source sentences
Summary
not rendering essential influencing on the xanthine oxidase activity in tissues of brain, liver
1 context sentence(design, population, supporting numbers)
Summary · context
In activity the comparative analysis of metabolic effects delta--sleep inducing peptide (DSIP) in tissues and erythrocytes of intact rats and under cold stress is conducted.
Report a problemFND-1263547704
05AnimalAnimal study (in vivo)Mechanism
In rats under cold stress, DSIP activated myeloperoxidase activity.
In plain wordsIn rats under cold stress, DSIP raised myeloperoxidase activity.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
IncreaseMyeloperoxidase activity under stress
Study
ratn: not reported in source
Outcome group
Oxidative stress · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
activates the myeloperoxidase activity, depresses the xanthine oxidase activity for rats at stress.
1 context sentence(design, population, supporting numbers)
Summary · context
In activity the comparative analysis of metabolic effects delta--sleep inducing peptide (DSIP) in tissues and erythrocytes of intact rats and under cold stress is conducted.
Report a problemFND-1263547705
06AnimalAnimal study (in vivo)Mechanism
In rats under cold stress, DSIP depressed xanthine oxidase activity.
In plain wordsIn rats under cold stress, DSIP lowered xanthine oxidase activity.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
DecreaseXanthine oxidase activity under stress
Study
ratn: not reported in source
Outcome group
Oxidative stress · Whole body
Studied dose
Dose not stated
Source sentences
Summary
depresses the xanthine oxidase activity for rats at stress.
1 context sentence(design, population, supporting numbers)
Summary · context
In activity the comparative analysis of metabolic effects delta--sleep inducing peptide (DSIP) in tissues and erythrocytes of intact rats and under cold stress is conducted.
Report a problemFND-1263547706
07AnimalAnimal study (in vivo)Mechanism
In intact rats and in rats under stress, the membranotropic effect of DSIP was connected to increased stability of protein-lipid interplays.
In plain wordsIn rats, DSIP was linked to more stable protein-lipid interactions in membranes, with and without stress.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
IncreaseStability of protein-lipid interplays in erythrocyte membranes
Study
ratn: not reported in source
Outcome group
Oxidative stress · Whole body
Studied dose
Dose not stated
Source sentences
Summary
The membranotropic effect of DSIP in the norm and under stress is connected to increase of stability of protein--lipid interplays.
1 context sentence(design, population, supporting numbers)
Summary · context
In activity the comparative analysis of metabolic effects delta--sleep inducing peptide (DSIP) in tissues and erythrocytes of intact rats and under cold stress is conducted.
Report a problemFND-1263547707
08AnimalAnimal study (in vivo)Mechanism
In rats under stress, DSIP decreased the polarity of the lipid phase of erythrocyte membranes.
In plain wordsIn stressed rats, DSIP lowered the polarity of the lipid layer in red blood cell membranes.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
DecreasePolarity of lipid phase of erythrocyte membranes under stress
Study
ratn: not reported in source
Outcome group
Oxidative stress · Whole body
Studied dose
Dose not stated
Source sentences
Summary
The membranostabilizing effect of DSIP in conditions of stress is characterized decrease of polarity of lipid phase and negative surface charge of erythrocyte membranes, modified in course of lipid peroxidation.
1 context sentence(design, population, supporting numbers)
Summary · context
In activity the comparative analysis of metabolic effects delta--sleep inducing peptide (DSIP) in tissues and erythrocytes of intact rats and under cold stress is conducted.
Report a problemFND-1263547708
09AnimalAnimal study (in vivo)Mechanism
In rats under stress, DSIP decreased the negative surface charge of erythrocyte membranes.
In plain wordsIn stressed rats, DSIP lowered the negative surface charge of red blood cell membranes.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
DecreaseNegative surface charge of erythrocyte membranes under stress
Study
ratn: not reported in source
Outcome group
Oxidative stress · Whole body
Studied dose
Dose not stated
Source sentences
Summary
The membranostabilizing effect of DSIP in conditions of stress is characterized decrease of polarity of lipid phase and negative surface charge of erythrocyte membranes, modified in course of lipid peroxidation.
1 context sentence(design, population, supporting numbers)
Summary · context
In activity the comparative analysis of metabolic effects delta--sleep inducing peptide (DSIP) in tissues and erythrocytes of intact rats and under cold stress is conducted.
Report a problemFND-1263547709

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 17:28 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

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