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Study · Animal study (in vivo) · rat · 2021

2 results

Delta Sleep-Inducing Peptide Recovers Motor Function in SD Rats after Focal Stroke.

Tukhovskaya EA, Ismailova AM, Shaykhutdinova ER, Slashcheva GA, Prudchenko IA, Mikhaleva II, Khokhlova ON, Murashev AN, Ivanov VT

Molecules (Basel, Switzerland)26 Aug 2021Cited by 1 (Europe PMC)

PMID34500605 (opens in a new tab)PMCIDPMC8434407 (opens in a new tab)DOI10.3390/molecules26175173 (opens in a new tab)PepBankPUB-34500605
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Summary

Background and Objectives: Mutual effect of the preliminary and therapeutic intranasal treatment of SD rats with DSIP (8 days) on the outcome of focal stroke, induced with intraluminal middle cerebral occlusion (MCAO), was investigated. Materials and Methods: The groups were the following: MCAO + vehicle, MCAO + DSIP, and SHAM-operated. DSIP or vehicle was applied nasally 60 (±15) minutes prior to the occlusion and for 7 days after reperfusion at dose 120 µg/kg. The battery of behavioral tests was performed on 1, 3, 7, 14, and 21 days after MCAO. Motor coordination and balance and bilateral asymmetry were tested. At the end of the study, animals were euthanized, and their brains were perfused, serial cryoslices were made, and infarction volume in them was calculated. Results: Although brain infarction in DSIP-treated animals was smaller than in vehicle-treated animals, the difference was not significant. However, motor performance in the rotarod test significantly recovered in DSIP-treated animals. Conclusions: Intranasal administration of DSIP in the course of 8 days leads to accelerated recovery of motor functions.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with focal stroke, intranasal DSIP did not significantly reduce brain infarction volume compared with vehicle.

    In plain wordsIn rats with stroke, DSIP did not significantly shrink the brain damage area compared with vehicle.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeBrain infarction volume
    Study

    ratn: not reported in source

    Focal stroke (MCAO)
    Comparator
    Vehicle
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    120 µg/kg · intranasal · 8 daysAs given in this study (rat).

    Source sentences

    Summary
    Although brain infarction in DSIP-treated animals was smaller than in vehicle-treated animals, the difference was not significant.
    3 context sentences
    Summary · context
    Mutual effect of the preliminary and therapeutic intranasal treatment of SD rats with DSIP (8 days) on the outcome of focal stroke, induced with intraluminal middle cerebral occlusion (MCAO), was investigated.
    Summary · context
    The groups were the following: MCAO + vehicle, MCAO + DSIP, and SHAM-operated.
    Summary · context
    DSIP or vehicle was applied nasally 60 (±15) minutes prior to the occlusion and for 7 days after reperfusion at dose 120 µg/kg.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with focal stroke, intranasal DSIP significantly improved recovery of rotarod motor performance compared with vehicle.

    In plain wordsIn rats with stroke, DSIP helped movement recover more than vehicle did.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseMotor performance recovery (rotarod)
    Study

    ratn: not reported in source

    Focal stroke (MCAO)
    Comparator
    Vehicle
    Outcome group
    Exercise and physical function · Nervous system and cognition
    Studied dose
    120 µg/kg · intranasal · 8 daysAs given in this study (rat).

    Source sentences

    Summary
    However, motor performance in the rotarod test significantly recovered in DSIP-treated animals.
    3 context sentences
    Summary · context
    Mutual effect of the preliminary and therapeutic intranasal treatment of SD rats with DSIP (8 days) on the outcome of focal stroke, induced with intraluminal middle cerebral occlusion (MCAO), was investigated.
    Summary · context
    The groups were the following: MCAO + vehicle, MCAO + DSIP, and SHAM-operated.
    Summary · context
    DSIP or vehicle was applied nasally 60 (±15) minutes prior to the occlusion and for 7 days after reperfusion at dose 120 µg/kg.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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