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Study · Animal study (in vivo) · rat · 1987

6 results

Delta sleep inducing peptide (DSIP) stimulates the release of LH but not FSH via a hypothalamic site of action in the rat.

Iyer KS, McCann SM

Brain research bulletin1 Nov 1987Cited by 9 (Europe PMC)

PMID3121137 (opens in a new tab)DOI10.1016/0361-9230(87)90069-4 (opens in a new tab)PepBankPUB-03121137
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized rats, intraventricular DSIP significantly raised LH levels within 30 min, and the rise lasted for 2 hours.

    In plain wordsIn rats without ovaries, DSIP given into the brain raised luteinizing hormone levels within 30 minutes for about 2 hours.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseLH after intraventricular DSIP (5 micrograms)
    Study

    ratn: not reported in source

    Long-term ovariectomized Sprague-Dawley rats
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    5 micrograms · intraventricular (3rd ventricle)As given in this study (rat).

    Source sentences

    Summary
    Long term ovariectomized (OVX) Sprague-Dawley rats were injected intraventricularly (3rd ventricle) with 5 micrograms (2 microliter) of DSIP. This caused a significant elevation (p = 0.01) of LH levels within 30 min. The values remained elevated for 2 hr; however, FSH levels remained unchanged.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized rats, intraventricular DSIP did not change FSH levels.

    In plain wordsIn rats without ovaries, DSIP given into the brain did not change follicle-stimulating hormone levels.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeFSH after intraventricular DSIP
    Study

    ratn: not reported in source

    Long-term ovariectomized Sprague-Dawley rats
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    5 micrograms · intraventricular (3rd ventricle)As given in this study (rat).

    Source sentences

    Summary
    Long term ovariectomized (OVX) Sprague-Dawley rats were injected intraventricularly (3rd ventricle) with 5 micrograms (2 microliter) of DSIP.
    1 context sentence
    Summary · context
    however, FSH levels remained unchanged.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized rats, the minimal effective intraventricular DSIP dose to raise LH was 1 microgram.

    In plain wordsIn rats without ovaries, the smallest DSIP dose into the brain that raised luteinizing hormone was 1 microgram.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseMinimal effective DSIP dose for LH rise
    Study

    ratn: not reported in source

    Long-term ovariectomized Sprague-Dawley rats
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    1 microgram (minimal effective) · intraventricular (3rd ventricle)As given in this study (rat).

    Measurements

    Minimal effective dose
    1 microgram
    LH

    Source sentences

    Summary
    The minimal effective dose of DSIP to evoke this effect was 1 microgram.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized rats pretreated with estradiol, intraventricular DSIP (5 micrograms) raised LH even more, significantly at 30 and 60 min.

    In plain wordsIn rats without ovaries given estradiol first, DSIP given into the brain raised luteinizing hormone even more.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseLH after DSIP with estradiol pretreatment
    Study

    ratn: not reported in source

    Ovariectomized rats pretreated with estradiol
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    5 micrograms · intraventricular (3rd ventricle)As given in this study (rat).

    Source sentences

    Summary
    If plasma PH was lowered by pretreatment of the animals with estradiol, the 5 micrograms dose evoked an even greater effect to elevate LH significantly at 30 and 60 min following its intraventricular injection.
  5. 05LabEx vivo tissueEfficacy outcome

    In male rat median eminence fragments in vitro, DSIP at 10(-7) M significantly increased LHRH release.

    In plain wordsIn rat brain tissue in a dish, DSIP at a high concentration increased the release of LHRH.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseLHRH release from median eminence
    Study

    ratn: not reported in source

    Median eminence fragments from male rats
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    10(-10) to 10(-7) MAs given in this study (rat).

    Source sentences

    Summary
    To evaluate its possible action on the hypothalamus, median eminence (ME) fragments from male rats were incubated in vitro with DSIP in varying concentrations from 10(-7) to 10(-10) M. There was a significant (p less than 0.001) increase in LHRH released from the ME at a concentration of DSIP of 10(-7) M.
  6. 06LabIn vitro (cells)Efficacy outcome

    In cultured pituitary cells from ovariectomized rats, DSIP produced no response.

    In plain wordsIn rat pituitary cells in a dish, DSIP caused no response.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changePituitary cell response to DSIP
    Study

    ratn: not reported in source

    Dispersed overnight cultured pituitary cells from ovariectomized rats
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    10(-12) to 10(-7) MAs given in this study (rat).

    Source sentences

    Summary
    To determine the site of action of DSIP, dispersed, overnight cultured pituitary cells from OVX rats were incubated with varying concentrations (10(-7) to 10(-12) M) of DSIP in an in vitro system. There was no response to DSIP from the cells in the above system.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

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Terms as the source lists them.

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