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Study · Animal study (in vivo) · rabbit · 1991

4 results

[Hemodynamics as affected by delta-sleep-inducing peptide].

Pimenova TI

Patologicheskaia fiziologiia i eksperimental'naia terapiia1 Jan 1991

PMID1818276 (opens in a new tab)PepBankPUB-01818276
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rabbits, intravenous DSIP (60 nmol/kg) affected central hemodynamics, with two heterodirectional responses of heart and vessels.

    In plain wordsIn rabbits, DSIP changed blood circulation measures, with some animals responding mainly through the heart and others through the vessels.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    MixedCentral hemodynamic parameters
    Study

    rabbitn = 11

    Comparator
    Control group (9 rabbits)
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    60 nmol/kg · intravenousAs given in this study (rabbit).

    Source sentences

    Summary
    The effect of intravenous delta-sleep-inducing peptide (DSIP), 60 nmol/kg in 5 ml of saline, on central hemodynamic parameters was studied in 11 experiments.
    4 context sentences
    Summary · context
    Two heterodirectional responses of the heart and vessels occurred in the animals given DSIP, which made them divide into 2 groups: those with a predominantly cardiac type of hemodynamic responses (n = 5) and animals with a predominantly vascular type of hemodynamic responses (n = 6).
    Summary · context
    The results of the studies showed that DSIP affected central hemodynamics of intact animals
    Summary · context
    The study was performed on 20 male rabbits.
    Summary · context
    Nine rabbits formed the control group.
  2. 02AnimalAnimal study (in vivo)Safety outcome

    In rabbits, the DSIP-induced changes in hemodynamic parameters stayed within the physiological normal range.

    In plain wordsIn rabbits, the circulation changes after DSIP stayed within the normal range.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Not applicableSize of hemodynamic changes relative to physiological range
    Study

    rabbitn = 11

    Comparator
    Control group (9 rabbits)
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    60 nmol/kg · intravenousAs given in this study (rabbit).

    Source sentences

    Summary
    The changes in hemodynamic parameters were, however, within the physiological normal range.
    2 context sentences
    Summary · context
    The study was performed on 20 male rabbits.
    Summary · context
    Nine rabbits formed the control group.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rabbits given DSIP, 6 animals had a predominantly vascular type of hemodynamic response.

    In plain wordsIn rabbits given DSIP, 6 animals responded mainly through the blood vessels.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Not applicableAnimals with predominantly vascular type of hemodynamic response
    Study

    rabbitn = 6

    Outcome group
    Heart function · Cardiovascular
    Studied dose
    60 nmol/kg · intravenousAs given in this study (rabbit).

    Measurements

    animals with vascular type response
    6 animals
    DSIP

    Source sentences

    Summary
    Two heterodirectional responses of the heart and vessels occurred in the animals given DSIP, which made them divide into 2 groups: those with a predominantly cardiac type of hemodynamic responses (n = 5) and animals with a predominantly vascular type of hemodynamic responses (n = 6).
    2 context sentences
    Summary · context
    The study was performed on 20 male rabbits.
    Summary · context
    Nine rabbits formed the control group.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rabbits given DSIP, 5 animals had a predominantly cardiac type of hemodynamic response.

    In plain wordsIn rabbits given DSIP, 5 animals responded mainly through the heart.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Not applicableAnimals with predominantly cardiac type of hemodynamic response
    Study

    rabbitn = 5

    Outcome group
    Heart function · Cardiovascular
    Studied dose
    60 nmol/kg · intravenousAs given in this study (rabbit).

    Measurements

    animals with cardiac type response
    5 animals
    DSIP

    Source sentences

    Summary
    Two heterodirectional responses of the heart and vessels occurred in the animals given DSIP, which made them divide into 2 groups: those with a predominantly cardiac type of hemodynamic responses (n = 5) and animals with a predominantly vascular type of hemodynamic responses (n = 6).
    2 context sentences
    Summary · context
    The study was performed on 20 male rabbits.
    Summary · context
    Nine rabbits formed the control group.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 17:28 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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