Delta sleep-inducing peptide as a factor increasing the content of substance P in the hypothalamus and the resistance of rats to emotional stress.

Salieva RM, Yanovskii K, Ratsak R, Trofimova YaI, Oeme P, Sudakov KV, Yumatov EA

Neuroscience and behavioral physiology1 Jul 1992Cited by 2 (Europe PMC)

PMID1382246DOI10.1007/bf01182865PepBankPUB-01382246

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In male rats, DSIP significantly increased the average content of substance P in the hypothalamus.
In plain wordsIn rats, DSIP raised the amount of substance P in the hypothalamus.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
IncreaseHypothalamic substance P content
Study
ratn: not reported in source
male rats of the August line
Outcome group
Stress hormones · Nervous system and cognition
Studied dose
60 and 120 nmole/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
It was demonstrated that the administration of DSIP significantly increases the average content of SP in the hypothalamus, as well as its content in animals resistant to and predisposed to emotional stress.
1 context sentence(design, population, supporting numbers)
Summary · context
The influence of delta sleep-inducing peptide (DSIP, 60 and 120 nmole/kg, intraperitoneally) on the content of substance P (SP) in the hypothalamus of rats was studied in male rats of the August line.
Report a problemFND-0138224601
02AnimalAnimal study (in vivo)Efficacy outcome
In rats resistant to and predisposed to emotional stress, DSIP increased the content of substance P in the hypothalamus.
In plain wordsIn rats, DSIP raised hypothalamic substance P in both stress-resistant and stress-prone animals.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
IncreaseHypothalamic substance P in stress-resistant and stress-predisposed rats
Study
ratn: not reported in source
male rats of the August line
Outcome group
Stress hormones · Nervous system and cognition
Studied dose
60 and 120 nmole/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
It was demonstrated that the administration of DSIP significantly increases the average content of SP in the hypothalamus, as well as its content in animals resistant to and predisposed to emotional stress.
1 context sentence(design, population, supporting numbers)
Summary · context
The influence of delta sleep-inducing peptide (DSIP, 60 and 120 nmole/kg, intraperitoneally) on the content of substance P (SP) in the hypothalamus of rats was studied in male rats of the August line.
Report a problemFND-0138224602
03AnimalAnimal study (in vivo)Efficacy outcome
In rats under emotional stress, daily DSIP given before stress raised hypothalamic substance P that had been decreased by the stress.
In plain wordsIn stressed rats, daily DSIP given beforehand raised the hypothalamic substance P that stress had lowered.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
IncreaseHypothalamic substance P during emotional stress, daily DSIP before stress
Study
ratn: not reported in source
male rats of the August line
Outcome group
Stress hormones · Nervous system and cognition
Studied dose
60 and 120 nmole/kg · intraperitoneal · dailyAs given in this study (rat).
Source sentences
Summary
A daily one-time administration of DSIP before placing the rats in conditions of stress increases the content of SP in the hypothalamus which was decreased during emotional stress.
1 context sentence(design, population, supporting numbers)
Summary · context
The influence of delta sleep-inducing peptide (DSIP, 60 and 120 nmole/kg, intraperitoneally) on the content of substance P (SP) in the hypothalamus of rats was studied in male rats of the August line.
Report a problemFND-0138224603
04AnimalAnimal study (in vivo)Efficacy outcome
In rats exposed to a stressor, a preliminary one-time DSIP dose increased substance P content in the hypothalamus.
In plain wordsIn stressed rats, one earlier DSIP dose raised substance P in the hypothalamus.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
IncreaseHypothalamic substance P after a one-time DSIP dose before a stressor
Study
ratn: not reported in source
male rats of the August line
Outcome group
Stress hormones · Nervous system and cognition
Studied dose
60 and 120 nmole/kg · intraperitoneal · single administrationAs given in this study (rat).
Source sentences
Summary
The preliminary one-time administration of DSIP to animals subjected to a stressor influence also increases the SP content in the hypothalamus.
1 context sentence(design, population, supporting numbers)
Summary · context
The influence of delta sleep-inducing peptide (DSIP, 60 and 120 nmole/kg, intraperitoneally) on the content of substance P (SP) in the hypothalamus of rats was studied in male rats of the August line.
Report a problemFND-0138224604
05AnimalAnimal study (in vivo)Efficacy outcome
In rats under emotional stress, one-time DSIP at 60 nmole/kg sharply decreased adrenal hypertrophy.
In plain wordsIn stressed rats, one DSIP dose sharply reduced the enlargement of the adrenal glands.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
DecreaseAdrenal hypertrophy under stress
Study
ratn: not reported in source
male rats of the August line
Outcome group
Stress hormones · Endocrine and hormones
Studied dose
60 nmole/kg · intraperitoneal · single administrationAs given in this study (rat).
Source sentences
Summary
It was established that a one-time administration of DSIP in a dose of 60 nmole/kg sharply decreases the classical manifestations of stress such as the hypertrophy of the adrenals and involution of the thymus.
1 context sentence(design, population, supporting numbers)
Summary · context
The influence of delta sleep-inducing peptide (DSIP, 60 and 120 nmole/kg, intraperitoneally) on the content of substance P (SP) in the hypothalamus of rats was studied in male rats of the August line.
Report a problemFND-0138224605
06AnimalAnimal study (in vivo)Efficacy outcome
In rats under emotional stress, one-time DSIP at 60 nmole/kg sharply decreased thymus involution.
In plain wordsIn stressed rats, one DSIP dose sharply reduced shrinking of the thymus.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
DecreaseThymus involution under stress
Study
ratn: not reported in source
male rats of the August line
Outcome group
Stress hormones · Immune and inflammation
Studied dose
60 nmole/kg · intraperitoneal · single administrationAs given in this study (rat).
Source sentences
Summary
It was established that a one-time administration of DSIP in a dose of 60 nmole/kg sharply decreases the classical manifestations of stress such as the hypertrophy of the adrenals and involution of the thymus.
1 context sentence(design, population, supporting numbers)
Summary · context
The influence of delta sleep-inducing peptide (DSIP, 60 and 120 nmole/kg, intraperitoneally) on the content of substance P (SP) in the hypothalamus of rats was studied in male rats of the August line.
Report a problemFND-0138224606

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 09:43 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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MeSH terms

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