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Study · Randomized controlled trial · n = 11 · 1989

4 results

Reduction of immunoreactive ACTH in plasma following intravenous injection of delta sleep-inducing peptide in man.

Bjartell A, Ekman R, Bergquist S, Widerlöv E

Psychoneuroendocrinology1 Jan 1989Cited by 14 (Europe PMC)

PMID2554357 (opens in a new tab)DOI10.1016/0306-4530(89)90004-8 (opens in a new tab)PepBankPUB-02554357
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

  1. 01HumanRandomized controlled trialMechanism

    In healthy men, a single intravenous dose of DSIP reduced plasma ACTH-like immunoreactivity for at least 3 hr compared with saline.

    In plain wordsIn healthy men, one DSIP injection lowered a stress-hormone marker (ACTH-like) in blood for at least 3 hours compared with saline.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreasePlasma ACTH-like immunoreactivity
    Study

    n = 11

    Comparator
    Saline
    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    25 nmol/kg BW · intravenous · single doseAs given in this study (human).

    Source sentences

    Summary
    A significant reduction of ACTH-like immunoreactivity (ACTH-LI) in plasma was detected for at least 3 hr after the DSIP injection, compared to the control subjects, in whom a slightly elevated concentration of ACTH-LI occurred.
    1 context sentence
    Summary · context
    Eleven healthy male volunteers, ages 25-39 years, received a single dose of synthetic delta sleep-inducing peptide (DSIP) (25 nmol/kg BW) or saline intravenously in a randomized cross-over, double-blind study.
  2. 02HumanRandomized controlled trialMechanism

    In healthy men, plasma cortisol levels were unaffected by a single intravenous dose of DSIP and followed the normal diurnal decline.

    In plain wordsIn healthy men, one DSIP injection did not change blood cortisol, which followed its normal daily decline.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changePlasma cortisol
    Study

    n = 11

    Comparator
    Saline
    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    25 nmol/kg BW · intravenous · single doseAs given in this study (human).

    Source sentences

    Summary
    Plasma cortisol levels were unaffected and followed the normal diurnal decline.
    1 context sentence
    Summary · context
    Eleven healthy male volunteers, ages 25-39 years, received a single dose of synthetic delta sleep-inducing peptide (DSIP) (25 nmol/kg BW) or saline intravenously in a randomized cross-over, double-blind study.
  3. 03HumanRandomized controlled trialMechanism

    In healthy men, urinary cortisol did not differ between the DSIP and saline conditions.

    In plain wordsIn healthy men, urine cortisol did not differ between DSIP and saline.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeUrinary cortisol
    Study

    n = 11

    Comparator
    Saline
    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    25 nmol/kg BW · intravenous · single doseAs given in this study (human).

    Source sentences

    Summary
    No differences in urinary cortisol or monoamine metabolite concentrations occurred between the two groups.
    1 context sentence
    Summary · context
    Eleven healthy male volunteers, ages 25-39 years, received a single dose of synthetic delta sleep-inducing peptide (DSIP) (25 nmol/kg BW) or saline intravenously in a randomized cross-over, double-blind study.
  4. 04HumanRandomized controlled trialMechanism

    In healthy men, urinary monoamine metabolite concentrations did not differ between the DSIP and saline conditions.

    In plain wordsIn healthy men, urine levels of monoamine breakdown products did not differ between DSIP and saline.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeUrinary monoamine metabolites
    Study

    n = 11

    Comparator
    Saline
    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    25 nmol/kg BW · intravenous · single doseAs given in this study (human).

    Source sentences

    Summary
    No differences in urinary cortisol or monoamine metabolite concentrations occurred between the two groups.
    1 context sentence
    Summary · context
    Eleven healthy male volunteers, ages 25-39 years, received a single dose of synthetic delta sleep-inducing peptide (DSIP) (25 nmol/kg BW) or saline intravenously in a randomized cross-over, double-blind study.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    27 Oct 2026, 16:35 UTC

    Study data updated · source update from Europe PMC

  2. Version 2

    9 Oct 2026, 18:17 UTC

    Study results updated

  3. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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