Effects of DSIP in man. Multifunctional psychophysiological properties besides induction of natural sleep.

Schneider-Helmert D, Schoenenberger GA

Neuropsychobiology1 Jan 1983Cited by 28 (Europe PMC)

PMID6689058DOI10.1159/000117964PepBankPUB-06689058

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

10 results from studies that gave the peptide. 10 results from people.

01HumanOther designSafety outcome
In five human studies with intravenous DSIP, compatibility was good.
In plain wordsIn five studies in people, DSIP injected into a vein was well tolerated.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
Not applicableCompatibility of DSIP
Study
n: not reported in source
Outcome group
Adverse events · Whole body
Studied dose
Dose not stated · intravenousAs given in this study (human).
Source sentences
Summary
Compatibility of DSIP was good.
1 context sentence(design, population, supporting numbers)
Summary · context
Five different human studies were carried out with single and repeated intravenous injections of DSIP under double-blind conditions, and with assessing treatment effects by psychophysiological tests and polygraphic recordings.
Report a problemFND-0668905801
02HumanOther designEfficacy outcome
In humans, intravenous DSIP induced sleep after a latency of 1 h.
In plain wordsIn people, sleep began about 1 hour after a DSIP injection.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
Not applicableLatency of sleep induction
Study
n: not reported in source
Outcome group
Sleep · Sleep
Studied dose
Dose not stated · intravenousAs given in this study (human).
Measurements
Sleep induction latency
1 h
humans
Source sentences
Summary
A latency of sleep induction of 1 h
1 context sentence(design, population, supporting numbers)
Summary · context
Five different human studies were carried out with single and repeated intravenous injections of DSIP under double-blind conditions, and with assessing treatment effects by psychophysiological tests and polygraphic recordings.
Report a problemFND-0668905802
03HumanOther designEfficacy outcome
In humans, the sleep effect of intravenous DSIP lasted up to 20 h.
In plain wordsIn people, the sleep effect of DSIP lasted up to 20 hours.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
Not applicableDuration of sleep after DSIP
Study
n: not reported in source
Outcome group
Sleep · Sleep
Studied dose
Dose not stated · intravenousAs given in this study (human).
Measurements
Duration of effect
≤ 20 h
humans
Source sentences
Summary
A latency of sleep induction of 1 h, but a duration of up to 20 h was found.
1 context sentence(design, population, supporting numbers)
Summary · context
Five different human studies were carried out with single and repeated intravenous injections of DSIP under double-blind conditions, and with assessing treatment effects by psychophysiological tests and polygraphic recordings.
Report a problemFND-0668905803
04HumanOther designEfficacy outcome
In humans, intravenous DSIP confirmed the somnogenic properties first seen in animal studies.
In plain wordsIn people, DSIP promoted sleep, as earlier animal studies had shown.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
IncreaseSleep promotion (somnogenic effect)
Study
n: not reported in source
Outcome group
Sleep · Sleep
Studied dose
Dose not stated · intravenousAs given in this study (human).
Source sentences
Summary
The somnogenic properties, initially proven in animal studies, were confirmed.
1 context sentence(design, population, supporting numbers)
Summary · context
Five different human studies were carried out with single and repeated intravenous injections of DSIP under double-blind conditions, and with assessing treatment effects by psychophysiological tests and polygraphic recordings.
Report a problemFND-0668905804
05HumanOther designEfficacy outcome
In humans, there were indications of specific effects of DSIP on chronobiological regulations.
In plain wordsIn people, there were signs that DSIP affects body clock regulation.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
Direction not reportedChronobiological regulation
Study
n: not reported in source
Outcome group
Sleep · Sleep
Studied dose
Dose not stated · intravenousAs given in this study (human).
Source sentences
Summary
Indications of specific effects on chronobiological regulations were found.
1 context sentence(design, population, supporting numbers)
Summary · context
Five different human studies were carried out with single and repeated intravenous injections of DSIP under double-blind conditions, and with assessing treatment effects by psychophysiological tests and polygraphic recordings.
Report a problemFND-0668905805
06HumanOther designEfficacy outcome
In insomniacs, four consecutive DSIP injections achieved a complete normalization of disturbed sleep.
In plain wordsIn people with insomnia, four DSIP injections in a row brought sleep back to normal.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
DecreaseDisturbed sleep in insomniacs
Study
n: not reported in source
Outcome group
Sleep · Sleep
Studied dose
Dose not stated · intravenousAs given in this study (human).
Source sentences
Summary
A complete normalization of disturbed sleep was achieved by four consecutive injections to insomniacs.
1 context sentence(design, population, supporting numbers)
Summary · context
Five different human studies were carried out with single and repeated intravenous injections of DSIP under double-blind conditions, and with assessing treatment effects by psychophysiological tests and polygraphic recordings.
Report a problemFND-0668905806
07HumanOther designEfficacy outcome
In humans, DSIP induced higher alertness during the active awake state.
In plain wordsIn people, DSIP raised alertness while they were awake.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
IncreaseAlertness during the awake state
Study
n: not reported in source
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
Dose not stated · intravenousAs given in this study (human).
Source sentences
Summary
During the active awake state, DSIP induced higher alertness and better performance.
1 context sentence(design, population, supporting numbers)
Summary · context
Five different human studies were carried out with single and repeated intravenous injections of DSIP under double-blind conditions, and with assessing treatment effects by psychophysiological tests and polygraphic recordings.
Report a problemFND-0668905807
08HumanOther designEfficacy outcome
In humans, DSIP induced better performance during the active awake state.
In plain wordsIn people, DSIP led to better performance while they were awake.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
IncreasePerformance during the awake state
Study
n: not reported in source
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
Dose not stated · intravenousAs given in this study (human).
Source sentences
Summary
During the active awake state, DSIP induced higher alertness and better performance.
1 context sentence(design, population, supporting numbers)
Summary · context
Five different human studies were carried out with single and repeated intravenous injections of DSIP under double-blind conditions, and with assessing treatment effects by psychophysiological tests and polygraphic recordings.
Report a problemFND-0668905808
09HumanOther designEfficacy outcome
In humans, psychological tests and psychotherapist evaluation indicated improved stress tolerance with DSIP.
In plain wordsIn people, tests and therapist ratings pointed to better stress tolerance with DSIP.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
IncreaseStress tolerance
Study
n: not reported in source
Outcome group
Anxiety and mood · Mental health and mood
Studied dose
Dose not stated · intravenousAs given in this study (human).
Source sentences
Summary
Psychological tests and evaluation by psychotherapists indicated modulation of ego functions by DSIP in the direction of improved stress tolerance and coping ability.
1 context sentence(design, population, supporting numbers)
Summary · context
Five different human studies were carried out with single and repeated intravenous injections of DSIP under double-blind conditions, and with assessing treatment effects by psychophysiological tests and polygraphic recordings.
Report a problemFND-0668905809
10HumanOther designEfficacy outcome
In humans, psychological tests and psychotherapist evaluation indicated improved coping ability with DSIP.
In plain wordsIn people, tests and therapist ratings pointed to better coping ability with DSIP.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
IncreaseCoping ability
Study
n: not reported in source
Outcome group
Anxiety and mood · Mental health and mood
Studied dose
Dose not stated · intravenousAs given in this study (human).
Source sentences
Summary
Psychological tests and evaluation by psychotherapists indicated modulation of ego functions by DSIP in the direction of improved stress tolerance and coping ability.
1 context sentence(design, population, supporting numbers)
Summary · context
Five different human studies were carried out with single and repeated intravenous injections of DSIP under double-blind conditions, and with assessing treatment effects by psychophysiological tests and polygraphic recordings.
Report a problemFND-0668905810

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
9 Oct 2026, 18:17 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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