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Study · Not a test of the peptide alone · 1985

2 results

Aluminum alters the permeability of the blood-brain barrier to some non-peptides.

Banks WA, Kastin AJ

Neuropharmacology1 May 1985Cited by 40 (Europe PMC)

PMID4022265 (opens in a new tab)DOI10.1016/0028-3908(85)90025-5 (opens in a new tab)PepBankPUB-04022265
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone2

In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Delta sleep-inducing peptide (DSIP).

  1. 01AnimalNot a test of Delta sleep-inducing peptide (DSIP) aloneAnimal study (in vivo)Other

    In animals, intraperitoneal aluminum enhanced blood-brain barrier permeability to labelled N-Tyr-DSIP.

    In plain wordsIn animals, aluminum made the blood-brain barrier more permeable to a labelled form of DSIP; DSIP was used as a test molecule.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseBlood-brain barrier permeability to N-Tyr-DSIP with aluminum
    Study

    n: not reported in source

    Comparator
    Without aluminum
    Outcome group
    Pharmacokinetics · Pharmacology

    Source sentences

    Summary
    Aluminum enhanced the permeability of the blood-brain barrier to labelled prolactin, thyroxine, cortisol, growth hormone, N-Tyr-DSIP
    1 context sentence
    Summary · context
    N-Tyr-delta sleep-inducing peptide (N-Tyr-DSIP), growth hormone, thyroid stimulating hormone (TSH), prolactin and human and rat luteinizing hormone was examined.

    In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).

  2. 02AnimalNot a test of Delta sleep-inducing peptide (DSIP) aloneAnimal study (in vivo)Other

    In animals, incubating the peptide with aluminum before injection did not increase its penetration into the brain.

    In plain wordsIn animals, mixing the labelled peptide with aluminum before injection did not increase how much entered the brain.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changePenetration of N-Tyr-DSIP after incubation with aluminum
    Study

    n: not reported in source

    Comparator
    Without aluminum
    Outcome group
    Pharmacokinetics · Pharmacology

    Source sentences

    Summary
    Incubation of the peptide with aluminum before injection did not increase penetration, demonstrating that aluminum did not increase the permeability of the blood-brain barrier by acting directly on the peptide.
    1 context sentence
    Summary · context
    N-Tyr-delta sleep-inducing peptide (N-Tyr-DSIP), growth hormone, thyroid stimulating hormone (TSH), prolactin and human and rat luteinizing hormone was examined.

    In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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