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Study · Animal study (in vivo) · rat · 1984

3 results

Differential sleep-promoting effects of five sleep substances nocturnally infused in unrestrained rats.

Inoué S, Honda K, Komoda Y, Uchizono K, Ueno R, Hayaishi O

Proceedings of the National Academy of Sciences of the United States of America1 Oct 1984Cited by 39 (Europe PMC)

PMID6592612 (opens in a new tab)PMCIDPMC391896 (opens in a new tab)DOI10.1073/pnas.81.19.6240 (opens in a new tab)PepBankPUB-06592612
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats, a nocturnal intracerebroventricular infusion of DSIP rapidly increased slow-wave sleep.

    In plain wordsIn rats, DSIP infused into the brain ventricles at night quickly increased slow-wave sleep.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseSlow-wave sleep
    Study

    ratn: not reported in source

    freely moving male rats, nocturnal infusion
    Outcome group
    Sleep · Sleep
    Studied dose
    2.5 nmol · intracerebroventricular · 10 hrAs given in this study (rat).

    Source sentences

    Summary
    Delta-sleep-inducing peptide (2.5 nmol), which induces electroencephalogram delta (slow)-wave patterns, was rapidly effective in increasing both slow-wave sleep and paradoxical sleep but the effects were not long-lasting.
    1 context sentence
    Summary · context
    Sleep-inducing and sleep-maintaining effects of five different putative sleep substances were compared by the same nocturnal 10-hr intracerebroventricular infusion technique in otherwise saline-infused, freely moving male rats.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats, a nocturnal intracerebroventricular infusion of DSIP rapidly increased paradoxical sleep.

    In plain wordsIn rats, DSIP infused into the brain ventricles at night quickly increased paradoxical sleep.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseParadoxical sleep
    Study

    ratn: not reported in source

    freely moving male rats, nocturnal infusion
    Outcome group
    Sleep · Sleep
    Studied dose
    2.5 nmol · intracerebroventricular · 10 hrAs given in this study (rat).

    Source sentences

    Summary
    Delta-sleep-inducing peptide (2.5 nmol), which induces electroencephalogram delta (slow)-wave patterns, was rapidly effective in increasing both slow-wave sleep and paradoxical sleep but the effects were not long-lasting.
    1 context sentence
    Summary · context
    Sleep-inducing and sleep-maintaining effects of five different putative sleep substances were compared by the same nocturnal 10-hr intracerebroventricular infusion technique in otherwise saline-infused, freely moving male rats.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats, the sleep-increasing effects of nocturnal DSIP infusion were not long-lasting.

    In plain wordsIn rats, the extra sleep after DSIP infusion at night did not last long.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Not applicableDuration of the sleep effect
    Study

    ratn: not reported in source

    freely moving male rats, nocturnal infusion
    Outcome group
    Sleep · Sleep
    Studied dose
    2.5 nmol · intracerebroventricular · 10 hrAs given in this study (rat).

    Source sentences

    Summary
    Delta-sleep-inducing peptide (2.5 nmol), which induces electroencephalogram delta (slow)-wave patterns, was rapidly effective in increasing both slow-wave sleep and paradoxical sleep but the effects were not long-lasting.
    1 context sentence
    Summary · context
    Sleep-inducing and sleep-maintaining effects of five different putative sleep substances were compared by the same nocturnal 10-hr intracerebroventricular infusion technique in otherwise saline-infused, freely moving male rats.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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