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Study · Measured the body's own peptide · 1991

2 results

Reduced concentrations of galanin, arginine vasopressin, neuropeptide Y and peptide YY in the temporal cortex but not in the hypothalamus of brains from schizophrenics.

Frederiksen SO, Ekman R, Gottfries CG, Widerlöv E, Jonsson S

Acta psychiatrica Scandinavica1 Apr 1991Cited by 60 (Europe PMC)

PMID1709331 (opens in a new tab)DOI10.1111/j.1600-0447.1991.tb05539.x (opens in a new tab)PepBankPUB-01709331
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelObservational studyOther

    In postmortem brains of schizophrenic patients, DSIP concentration in the temporal cortex was not significantly reduced versus controls (reduction bordered on significance).

    In plain wordsIn schizophrenia brains, the body's own DSIP in the temporal cortex was not clearly lower than in controls; the drop nearly reached significance.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeDSIP concentration in temporal cortex
    Study

    n = 35

    Comparator
    Matched controls
    Outcome group
    Endogenous peptide levels · Mental health and mood

    Source sentences

    Summary
    DSIP reduction only bordered on significance.
    3 context sentences
    Summary · context
    In the temporal cortex of the schizophrenic brains, galanin, AVP, NPY and PYY were significantly reduced.
    Summary · context
    Concentrations of galanin, delta-sleep-inducing peptide (DSIP), corticotropin-releasing factor (CRF), arginine vasopressin (AVP), neuropeptide Y (NPY) and peptide YY (PYY) were determined in the hypothalamus and grey matter from the temporal cortex.
    Summary · context
    Postmortem investigations were performed in brains from 14 schizophrenic patients and 21 controls matched for age and autopsy latency.

    This result measures the body's own Delta sleep-inducing peptide (DSIP). Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelObservational studyOther

    In postmortem brains of schizophrenic patients, hypothalamic neuropeptide concentrations, including DSIP, did not differ significantly from controls.

    In plain wordsIn brains of people with schizophrenia, the body's own DSIP in the hypothalamus did not differ significantly from controls.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeDSIP concentration in hypothalamus
    Study

    n = 35

    Comparator
    Matched controls
    Outcome group
    Endogenous peptide levels · Mental health and mood

    Source sentences

    Summary
    A comparison of controls with schizophrenics showed no significant differences in hypothalamic neuropeptide concentrations.
    2 context sentences
    Summary · context
    Concentrations of galanin, delta-sleep-inducing peptide (DSIP), corticotropin-releasing factor (CRF), arginine vasopressin (AVP), neuropeptide Y (NPY) and peptide YY (PYY) were determined in the hypothalamus and grey matter from the temporal cortex.
    Summary · context
    Postmortem investigations were performed in brains from 14 schizophrenic patients and 21 controls matched for age and autopsy latency.

    This result measures the body's own Delta sleep-inducing peptide (DSIP). Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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