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Study · Animal study (in vivo) · rat · 1986

10 results

Oxytocin: an extremely potent inducer of penile erection and yawning in male rats.

Argiolas A, Melis MR, Gessa GL

European journal of pharmacology1 Nov 1986Cited by 96 (Europe PMC)

PMID3792449 (opens in a new tab)DOI10.1016/0014-2999(86)90277-3 (opens in a new tab)PepBankPUB-03792449
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In male rats, intracerebroventricular oxytocin at 5 to 90 ng induced penile erection.

    In plain wordsIn male rats, oxytocin injected into the brain ventricles caused penile erection.

    Peptide
    Oxytocin
    Outcome
    IncreasePenile erection
    Study

    ratn: not reported in source

    male rats
    Outcome group
    Sexual function · Reproductive and sexual health
    Studied dose
    5 to 90 ng (5-90 pmol) · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    The intracerebroventricular (i.c.v.) injection of oxytocin, in doses ranging from 5 to 90 ng (5-90 pmol) induced penile erection and yawning in male rats.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In male rats, intracerebroventricular oxytocin at 5 to 90 ng induced yawning.

    In plain wordsIn male rats, oxytocin injected into the brain ventricles caused yawning.

    Peptide
    Oxytocin
    Outcome
    IncreaseYawning
    Study

    ratn: not reported in source

    male rats
    Outcome group
    Locomotor and behavioral activity · Nervous system and cognition
    Studied dose
    5 to 90 ng (5-90 pmol) · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    The intracerebroventricular (i.c.v.) injection of oxytocin, in doses ranging from 5 to 90 ng (5-90 pmol) induced penile erection and yawning in male rats.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In male rats, intracerebroventricular oxytocin at doses higher than 100 ng did not induce the erection and yawning response.

    In plain wordsIn male rats, higher oxytocin doses did not cause erection or yawning.

    Peptide
    Oxytocin
    Outcome
    No significant changePenile erection and yawning at doses above 100 ng
    Study

    ratn: not reported in source

    male rats
    Outcome group
    Sexual function · Reproductive and sexual health
    Studied dose
    higher than 100 ng · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    Such response was not induced by doses of the peptide higher than 100 ng
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In male rats, intracerebroventricular DSIP at doses equimolar to oxytocin did not induce penile erection.

    In plain wordsIn male rats, DSIP injected into the brain ventricles did not cause penile erection.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changePenile erection after DSIP
    Study

    ratn: not reported in source

    male rats
    Outcome group
    Sexual function · Reproductive and sexual health
    Studied dose
    equimolar doses · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    Such response was not induced by doses of the peptide higher than 100 ng, nor by equimolar doses of i.c.v. [Arg8]vasopressin, ACTH-(1-24), alpha-MSH, rat corticotropin-releasing factor (rCRF), delta sleep-inducing peptide, neurotensin or substance P.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In male rats, intracerebroventricular DSIP at doses equimolar to oxytocin did not induce yawning.

    In plain wordsIn male rats, DSIP injected into the brain ventricles did not cause yawning.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeYawning after DSIP
    Study

    ratn: not reported in source

    male rats
    Outcome group
    Locomotor and behavioral activity · Nervous system and cognition
    Studied dose
    equimolar doses · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    Such response was not induced by doses of the peptide higher than 100 ng, nor by equimolar doses of i.c.v. [Arg8]vasopressin, ACTH-(1-24), alpha-MSH, rat corticotropin-releasing factor (rCRF), delta sleep-inducing peptide, neurotensin or substance P.

Studies that did not test the peptide alone5

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

  1. 06AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism

    In male rats, atropine and morphine prevented oxytocin-induced penile erection and yawning.

    In plain wordsIn male rats, atropine and morphine blocked the erection and yawning that oxytocin caused.

    Peptide
    Oxytocin
    Outcome
    DecreaseAtropine and morphine on oxytocin-induced erection and yawning
    Study

    ratn: not reported in source

    male rats
    Outcome group
    Sexual function · Reproductive and sexual health

    Source sentences

    Summary
    Oxytocin-induced penile erection and yawning were prevented by atropine and morphine
    1 context sentence
    Summary · context
    The intracerebroventricular (i.c.v.) injection of oxytocin, in doses ranging from 5 to 90 ng (5-90 pmol) induced penile erection and yawning in male rats.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  2. 07AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism

    In male rats, methylatropine and the opiate antagonist naloxone did not prevent oxytocin-induced penile erection and yawning.

    In plain wordsIn male rats, methylatropine and naloxone did not block the erection and yawning that oxytocin caused.

    Peptide
    Oxytocin
    Outcome
    No significant changeMethylatropine and naloxone on oxytocin-induced erection and yawning
    Study

    ratn: not reported in source

    male rats
    Outcome group
    Sexual function · Reproductive and sexual health

    Source sentences

    Summary
    Oxytocin-induced penile erection and yawning were prevented by atropine and morphine, but not by methylatropine or the opiate antagonist naloxone.
    1 context sentence
    Summary · context
    The intracerebroventricular (i.c.v.) injection of oxytocin, in doses ranging from 5 to 90 ng (5-90 pmol) induced penile erection and yawning in male rats.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  3. 08AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism

    In male rats, low doses of haloperidol did not prevent oxytocin-induced responses.

    In plain wordsIn male rats, low doses of haloperidol did not block the effects of oxytocin.

    Peptide
    Oxytocin
    Outcome
    No significant changeLow-dose haloperidol on oxytocin-induced responses
    Study

    ratn: not reported in source

    male rats
    Outcome group
    Sexual function · Reproductive and sexual health

    Source sentences

    Summary
    Haloperidol, a dopamine receptor antagonist, was ineffective at low doses; it partially prevented penile erection but not yawning at high doses.
    1 context sentence
    Summary · context
    The intracerebroventricular (i.c.v.) injection of oxytocin, in doses ranging from 5 to 90 ng (5-90 pmol) induced penile erection and yawning in male rats.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  4. 09AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism

    In male rats, high doses of haloperidol partially prevented oxytocin-induced penile erection.

    In plain wordsIn male rats, high doses of haloperidol partly blocked the erection that oxytocin caused.

    Peptide
    Oxytocin
    Outcome
    DecreaseHigh-dose haloperidol on oxytocin-induced penile erection
    Study

    ratn: not reported in source

    male rats
    Outcome group
    Sexual function · Reproductive and sexual health

    Source sentences

    Summary
    Haloperidol, a dopamine receptor antagonist, was ineffective at low doses; it partially prevented penile erection but not yawning at high doses.
    1 context sentence
    Summary · context
    The intracerebroventricular (i.c.v.) injection of oxytocin, in doses ranging from 5 to 90 ng (5-90 pmol) induced penile erection and yawning in male rats.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  5. 10AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism

    In male rats, high doses of haloperidol did not prevent oxytocin-induced yawning.

    In plain wordsIn male rats, high doses of haloperidol did not block the yawning that oxytocin caused.

    Peptide
    Oxytocin
    Outcome
    No significant changeHigh-dose haloperidol on oxytocin-induced yawning
    Study

    ratn: not reported in source

    male rats
    Outcome group
    Locomotor and behavioral activity · Nervous system and cognition

    Source sentences

    Summary
    Haloperidol, a dopamine receptor antagonist, was ineffective at low doses; it partially prevented penile erection but not yawning at high doses.
    1 context sentence
    Summary · context
    The intracerebroventricular (i.c.v.) injection of oxytocin, in doses ranging from 5 to 90 ng (5-90 pmol) induced penile erection and yawning in male rats.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:04 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:52 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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