[Opiate receptors and sleep. III. Effects of microinjections of DSIP (delta-sleep peptide) in the median thalamus, Periaqueductal gray matter and nucleus of the tractus solitarius of the rabbit (author's transl)].

Tissot R

Neuropsychobiology1 Jan 1981Cited by 21 (Europe PMC)

PMID6273764DOI10.1159/000117867PepBankPUB-06273764

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

3 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rabbits, DSIP microinjected into the median thalamus at optimal doses produced slow-wave sleep with abundant recruiting spindles.
In plain wordsIn rabbits, DSIP injected into a deep brain area caused slow-wave sleep.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
IncreaseSlow-wave sleep after microinjection in the median thalamus
Study
rabbitn: not reported in source
Outcome group
Sleep · Sleep
Studied dose
Dose not stated · intracerebral microinjectionAs given in this study (rabbit).
Source sentences
Summary
In the rabbit, microinjections of DSIP (delta-sleep peptide) at optimal doses in the median thalamus
2 context sentences(design, population, supporting numbers)
Summary · context
produce slow-wave sleep with abundant recruiting spindles.
Title · context
[Opiate receptors and sleep. III. Effects of microinjections of DSIP (delta-sleep peptide) in the median thalamus, Periaqueductal gray matter and nucleus of the tractus solitarius of the rabbit (author's transl)].
Report a problemFND-0627376401
02AnimalAnimal study (in vivo)Efficacy outcome
In rabbits, DSIP microinjected into the periaqueductal gray matter (22.5 nmol) produced slow-wave sleep with abundant recruiting spindles.
In plain wordsIn rabbits, DSIP injected into a deep brain area caused slow-wave sleep.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
IncreaseSlow-wave sleep after microinjection in the periaqueductal gray matter
Study
rabbitn: not reported in source
Outcome group
Sleep · Sleep
Studied dose
22.5 nmol · intracerebral microinjectionAs given in this study (rabbit).
Measurements
Dose
22.5 nmol
periaqueductal gray matter
Source sentences
Summary
In the rabbit, microinjections of DSIP (delta-sleep peptide) at optimal doses in the median thalamus, periaqueductal gray matter (22.5 nmol), and nucleus of the tractus solitarius (15.0 nmol) produce slow-wave sleep with abundant recruiting spindles.
1 context sentence(design, population, supporting numbers)
Title · context
[Opiate receptors and sleep. III. Effects of microinjections of DSIP (delta-sleep peptide) in the median thalamus, Periaqueductal gray matter and nucleus of the tractus solitarius of the rabbit (author's transl)].
Report a problemFND-0627376402
03AnimalAnimal study (in vivo)Efficacy outcome
In rabbits, DSIP microinjected into the nucleus of the tractus solitarius (15.0 nmol) produced slow-wave sleep with abundant recruiting spindles.
In plain wordsIn rabbits, DSIP injected into a deep brain area caused slow-wave sleep.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
IncreaseSlow-wave sleep after microinjection in the nucleus of the tractus solitarius
Study
rabbitn: not reported in source
Outcome group
Sleep · Sleep
Studied dose
15.0 nmol · intracerebral microinjectionAs given in this study (rabbit).
Measurements
Dose
15 nmol
nucleus of the tractus solitarius
Source sentences
Summary
In the rabbit, microinjections of DSIP (delta-sleep peptide) at optimal doses in the median thalamus, periaqueductal gray matter (22.5 nmol), and nucleus of the tractus solitarius (15.0 nmol) produce slow-wave sleep with abundant recruiting spindles.
1 context sentence(design, population, supporting numbers)
Title · context
[Opiate receptors and sleep. III. Effects of microinjections of DSIP (delta-sleep peptide) in the median thalamus, Periaqueductal gray matter and nucleus of the tractus solitarius of the rabbit (author's transl)].
Report a problemFND-0627376403

Studies that did not test the peptide alone1

In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Delta sleep-inducing peptide (DSIP).

04AnimalNot a test of Delta sleep-inducing peptide (DSIP) aloneAnimal study (in vivo)Mechanism
In rabbits, naloxone (160 micrograms intracerebrally) blocked the slow-wave sleep that DSIP microinjection produced.
In plain wordsIn rabbits, the drug naloxone blocked the sleep that DSIP caused.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
DecreaseNaloxone block of DSIP-induced slow-wave sleep
Study
rabbitn: not reported in source
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Source sentences
Summary
As is seen with morphine, this effect is blocked by naloxone (160 micrograms intracerebrally; i.c.).
1 context sentence(design, population, supporting numbers)
Title · context
[Opiate receptors and sleep. III. Effects of microinjections of DSIP (delta-sleep peptide) in the median thalamus, Periaqueductal gray matter and nucleus of the tractus solitarius of the rabbit (author's transl)].
In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).
Report a problemFND-0627376404

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 17:28 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

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