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Study · Randomized controlled trial · n = 16 · 1992

4 results

Effects of delta sleep-inducing peptide on sleep of chronic insomniac patients. A double-blind study.

Bes F, Hofman W, Schuur J, Van Boxtel C

Neuropsychobiology1 Jan 1992Cited by 8 (Europe PMC)

PMID1299794 (opens in a new tab)DOI10.1159/000118919 (opens in a new tab)PepBankPUB-01299794
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In chronic insomniac patients, DSIP gave higher objective sleep efficiency than placebo.

    In plain wordsIn people with long-term insomnia, DSIP gave higher measured sleep efficiency than placebo, but the effect was weak.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseSleep efficiency (polysomnography)
    Study

    n = 16

    Comparator
    Placebo (glucose solution)
    Outcome group
    Sleep · Sleep
    Studied dose
    25 nmol/kg body weight · intravenous · 3 consecutive nightsAs given in this study (human).

    Source sentences

    Summary
    The results for objective sleep quality indicated higher sleep efficiency and shorter sleep latency with DSIP as compared to placebo.
    2 context sentences
    Summary · context
    In the afternoon before the 3rd, 4th and 5th night, half of the patients received intravenously 25 nmol/kg body weight DSIP, and half of the patients a glucose solution (placebo).
    Summary · context
    The influence of delta sleep-inducing peptide (DSIP) on sleep was studied in 16 chronic insomniac patients according to a double-blind matched-pairs parallel-groups design.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In chronic insomniac patients, DSIP gave shorter objective sleep latency than placebo.

    In plain wordsIn people with long-term insomnia, DSIP shortened the time to fall asleep compared with placebo, but the effect was weak.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseSleep latency (polysomnography)
    Study

    n = 16

    Comparator
    Placebo (glucose solution)
    Outcome group
    Sleep · Sleep
    Studied dose
    25 nmol/kg body weight · intravenous · 3 consecutive nightsAs given in this study (human).

    Source sentences

    Summary
    The results for objective sleep quality indicated higher sleep efficiency and shorter sleep latency with DSIP as compared to placebo.
    2 context sentences
    Summary · context
    In the afternoon before the 3rd, 4th and 5th night, half of the patients received intravenously 25 nmol/kg body weight DSIP, and half of the patients a glucose solution (placebo).
    Summary · context
    The influence of delta sleep-inducing peptide (DSIP) on sleep was studied in 16 chronic insomniac patients according to a double-blind matched-pairs parallel-groups design.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In chronic insomniac patients, one measure of subjectively estimated tiredness decreased within the DSIP group.

    In plain wordsIn people with long-term insomnia, one tiredness rating fell within the DSIP group; this was not a comparison with placebo.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseSubjectively estimated tiredness
    Study

    n = 16

    Comparator
    Baseline within DSIP group
    Outcome group
    Sleep · Sleep
    Studied dose
    25 nmol/kg body weight · intravenous · 3 consecutive nightsAs given in this study (human).

    Source sentences

    Summary
    One measure of subjectively estimated tiredness decreased within the DSIP group.
    2 context sentences
    Summary · context
    In the afternoon before the 3rd, 4th and 5th night, half of the patients received intravenously 25 nmol/kg body weight DSIP, and half of the patients a glucose solution (placebo).
    Summary · context
    The influence of delta sleep-inducing peptide (DSIP) on sleep was studied in 16 chronic insomniac patients according to a double-blind matched-pairs parallel-groups design.
  4. 04HumanRandomized controlled trialEfficacy outcome

    In chronic insomniac patients, DSIP did not change subjective sleep quality or the other measures assessed.

    In plain wordsIn people with long-term insomnia, DSIP did not change self-rated sleep quality or other measures compared with placebo.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeSubjective sleep quality and other measures
    Study

    n = 16

    Comparator
    Placebo (glucose solution)
    Outcome group
    Sleep · Sleep
    Studied dose
    25 nmol/kg body weight · intravenous · 3 consecutive nightsAs given in this study (human).

    Source sentences

    Summary
    As none of the other measures, including subjective sleep quality, showed any change
    2 context sentences
    Summary · context
    In the afternoon before the 3rd, 4th and 5th night, half of the patients received intravenously 25 nmol/kg body weight DSIP, and half of the patients a glucose solution (placebo).
    Summary · context
    The influence of delta sleep-inducing peptide (DSIP) on sleep was studied in 16 chronic insomniac patients according to a double-blind matched-pairs parallel-groups design.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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