[Metabolic effects of delta-sleep inducing peptide during physiological aging of the organism].

Bondarenko TI, Maĭboroda EA, Mikhaleva II, Prudchenko IA

Eksperimental'naia i klinicheskaia farmakologiia1 Jan 2013

PMID24432565PepBankPUB-24432565

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats aged 2 to 24 months, subcutaneous DSIP favored normalization of age-related changes in carbohydrate metabolism.
In plain wordsIn rats, DSIP injections favored a return toward normal of age-related changes in sugar metabolism.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
Not applicableAge-related changes in carbohydrate metabolism
Study
ratn: not reported in source
physiological aging, rats aged 2 to 24 months
Outcome group
Glycemic control · Metabolic and weight
Studied dose
10 microg/100 g body weight · subcutaneous · 5 consecutive days every monthAs given in this study (rat).
Source sentences
Summary
favors normalization of the age-related changes in carbohydrate metabolism
1 context sentence(design, population, supporting numbers)
Summary · context
Subcutaneous injection of delta-sleep inducing peptide (DSIP) to postnatal rats (aged from 2 to 24 months) during 5 consecutive days every months at a dose of 10 microg/100 g body weight
Report a problemFND-2443256501
02AnimalAnimal study (in vivo)Efficacy outcome
In rats aged 2 to 24 months, subcutaneous DSIP showed a hypoglycemic effect, with a decrease in glycosylated hemoglobin in erythrocytes.
In plain wordsIn rats, DSIP injections lowered glycosylated hemoglobin, a marker of blood sugar.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
DecreaseGlycosylated hemoglobin in erythrocytes
Study
ratn: not reported in source
physiological aging, rats aged 2 to 24 months
Outcome group
Glycemic control · Metabolic and weight
Studied dose
10 microg/100 g body weight · subcutaneous · 5 consecutive days every monthAs given in this study (rat).
Source sentences
Summary
shows hypoglycemic effect, as manifested by a decrease in the level of glycosylated hemoglobin in erythrocytes of test rats
1 context sentence(design, population, supporting numbers)
Summary · context
Subcutaneous injection of delta-sleep inducing peptide (DSIP) to postnatal rats (aged from 2 to 24 months) during 5 consecutive days every months at a dose of 10 microg/100 g body weight
Report a problemFND-2443256502
03AnimalAnimal study (in vivo)Efficacy outcome
In rats of different ages, DSIP decreased serum total lipid level.
In plain wordsIn rats, DSIP injections lowered total lipids in the blood.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
DecreaseSerum total lipid level
Study
ratn: not reported in source
physiological aging, rats aged 2 to 24 months
Outcome group
Lipids · Metabolic and weight
Studied dose
10 microg/100 g body weight · subcutaneous · 5 consecutive days every monthAs given in this study (rat).
Source sentences
Summary
The administration of DSIP in postnatal rats of different age also led to a decrease in serum total lipid level
1 context sentence(design, population, supporting numbers)
Summary · context
Subcutaneous injection of delta-sleep inducing peptide (DSIP) to postnatal rats (aged from 2 to 24 months) during 5 consecutive days every months at a dose of 10 microg/100 g body weight
Report a problemFND-2443256503
04AnimalAnimal study (in vivo)Efficacy outcome
In rats of different ages, DSIP decreased total cholesterol level.
In plain wordsIn rats, DSIP injections lowered total cholesterol.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
DecreaseTotal cholesterol level
Study
ratn: not reported in source
physiological aging, rats aged 2 to 24 months
Outcome group
Lipids · Metabolic and weight
Studied dose
10 microg/100 g body weight · subcutaneous · 5 consecutive days every monthAs given in this study (rat).
Source sentences
Summary
The administration of DSIP in postnatal rats of different age also led to a decrease in serum total lipid level, total cholesterol level, and atherogenicity index and an increase in the level of high-density lipoprotein cholesterol.
1 context sentence(design, population, supporting numbers)
Summary · context
Subcutaneous injection of delta-sleep inducing peptide (DSIP) to postnatal rats (aged from 2 to 24 months) during 5 consecutive days every months at a dose of 10 microg/100 g body weight
Report a problemFND-2443256504
05AnimalAnimal study (in vivo)Efficacy outcome
In rats of different ages, DSIP decreased the atherogenicity index.
In plain wordsIn rats, DSIP injections lowered the atherogenicity index, a ratio of blood fats.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
DecreaseAtherogenicity index
Study
ratn: not reported in source
physiological aging, rats aged 2 to 24 months
Outcome group
Lipids · Metabolic and weight
Studied dose
10 microg/100 g body weight · subcutaneous · 5 consecutive days every monthAs given in this study (rat).
Source sentences
Summary
The administration of DSIP in postnatal rats of different age also led to a decrease in serum total lipid level, total cholesterol level, and atherogenicity index and an increase in the level of high-density lipoprotein cholesterol.
1 context sentence(design, population, supporting numbers)
Summary · context
Subcutaneous injection of delta-sleep inducing peptide (DSIP) to postnatal rats (aged from 2 to 24 months) during 5 consecutive days every months at a dose of 10 microg/100 g body weight
Report a problemFND-2443256505
06AnimalAnimal study (in vivo)Efficacy outcome
In rats of different ages, DSIP increased the level of high-density lipoprotein cholesterol.
In plain wordsIn rats, DSIP injections raised HDL cholesterol.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
IncreaseHigh-density lipoprotein cholesterol level
Study
ratn: not reported in source
physiological aging, rats aged 2 to 24 months
Outcome group
Lipids · Metabolic and weight
Studied dose
10 microg/100 g body weight · subcutaneous · 5 consecutive days every monthAs given in this study (rat).
Source sentences
Summary
The administration of DSIP in postnatal rats of different age also led to a decrease in serum total lipid level, total cholesterol level, and atherogenicity index and an increase in the level of high-density lipoprotein cholesterol.
1 context sentence(design, population, supporting numbers)
Summary · context
Subcutaneous injection of delta-sleep inducing peptide (DSIP) to postnatal rats (aged from 2 to 24 months) during 5 consecutive days every months at a dose of 10 microg/100 g body weight
Report a problemFND-2443256506

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 17:28 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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