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Study · Non-randomized trial · n = 6 · 1981

7 results

The influence of synthetic DSIP (delta-sleep-inducing-peptide) on disturbed human sleep.

Schneider-Helmert D, Schoenenberger GA

Experientia1 Jan 1981Cited by 12 (Europe PMC)

PMID7028502 (opens in a new tab)DOI10.1007/bf01971753 (opens in a new tab)PepBankPUB-07028502
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. 7 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In six middle-aged chronic insomniacs, acute intravenous DSIP led to longer sleep duration.

    In plain wordsIn six middle-aged adults with chronic insomnia, DSIP was followed by longer sleep.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseSleep duration
    Study

    n = 6

    Outcome group
    Sleep · Sleep
    Studied dose
    25 nmol/kg · intravenousAs given in this study (human).

    Source sentences

    Summary
    longer sleep duration
    1 context sentence
    Summary · context
    The effects of acute intravenous administration of synthetic DSIP, 25 nmoles/kg b.wt, on disturbed human sleep were tested in 6 middle-aged chronic insomniacs.
  2. 02HumanNon-randomized trialEfficacy outcome

    In six middle-aged chronic insomniacs, acute intravenous DSIP led to a higher quality of sleep.

    In plain wordsIn six middle-aged adults with chronic insomnia, DSIP was followed by better sleep quality.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseSleep quality
    Study

    n = 6

    Outcome group
    Sleep · Sleep
    Studied dose
    25 nmol/kg · intravenousAs given in this study (human).

    Source sentences

    Summary
    a higher quality of sleep
    1 context sentence
    Summary · context
    The effects of acute intravenous administration of synthetic DSIP, 25 nmoles/kg b.wt, on disturbed human sleep were tested in 6 middle-aged chronic insomniacs.
  3. 03HumanNon-randomized trialEfficacy outcome

    In six middle-aged chronic insomniacs, acute intravenous DSIP led to fewer sleep interruptions.

    In plain wordsIn six middle-aged adults with chronic insomnia, DSIP was followed by fewer sleep interruptions.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseSleep interruptions
    Study

    n = 6

    Outcome group
    Sleep · Sleep
    Studied dose
    25 nmol/kg · intravenousAs given in this study (human).

    Source sentences

    Summary
    with fewer interruptions
    1 context sentence
    Summary · context
    The effects of acute intravenous administration of synthetic DSIP, 25 nmoles/kg b.wt, on disturbed human sleep were tested in 6 middle-aged chronic insomniacs.
  4. 04HumanNon-randomized trialEfficacy outcome

    In six middle-aged chronic insomniacs, acute intravenous DSIP was followed by slightly more REM sleep.

    In plain wordsIn six middle-aged adults with chronic insomnia, DSIP was followed by slightly more REM sleep.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseREM sleep
    Study

    n = 6

    Outcome group
    Sleep · Sleep
    Studied dose
    25 nmol/kg · intravenousAs given in this study (human).

    Source sentences

    Summary
    slightly more REM-sleep
    1 context sentence
    Summary · context
    The effects of acute intravenous administration of synthetic DSIP, 25 nmoles/kg b.wt, on disturbed human sleep were tested in 6 middle-aged chronic insomniacs.
  5. 05HumanNon-randomized trialSafety outcome

    In six middle-aged chronic insomniacs, acute intravenous DSIP caused no day-time sedation or other side effects.

    In plain wordsIn six middle-aged adults with chronic insomnia, DSIP caused no day-time sedation or other side effects.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeDay-time sedation and other side effects
    Study

    n = 6

    Outcome group
    Adverse events · Whole body
    Studied dose
    25 nmol/kg · intravenousAs given in this study (human).

    Source sentences

    Summary
    no day-time sedation or other side effects though the sleep enhancing capacity was seen for up to 6 h of night sleep.
    1 context sentence
    Summary · context
    The effects of acute intravenous administration of synthetic DSIP, 25 nmoles/kg b.wt, on disturbed human sleep were tested in 6 middle-aged chronic insomniacs.
  6. 06HumanNon-randomized trialEfficacy outcome

    In six middle-aged chronic insomniacs, sleep-promoting effects of DSIP occurred only in the second hour after injection.

    In plain wordsIn six middle-aged adults with chronic insomnia, DSIP helped sleep only from the second hour after injection.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseSleep-promoting effect in the second hour after injection
    Study

    n = 6

    Outcome group
    Sleep · Sleep
    Studied dose
    25 nmol/kg · intravenousAs given in this study (human).

    Source sentences

    Summary
    Sleep-promoting effects occurred only in the second hour after injection, in the first hour a slight arousing effect was indicated.
    1 context sentence
    Summary · context
    The effects of acute intravenous administration of synthetic DSIP, 25 nmoles/kg b.wt, on disturbed human sleep were tested in 6 middle-aged chronic insomniacs.
  7. 07HumanNon-randomized trialEfficacy outcome

    In six middle-aged chronic insomniacs, a slight arousing effect of DSIP was indicated in the first hour after injection.

    In plain wordsIn six middle-aged adults with chronic insomnia, DSIP showed a slight arousing effect in the first hour.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseArousing effect in the first hour after injection
    Study

    n = 6

    Outcome group
    Sleep · Sleep
    Studied dose
    25 nmol/kg · intravenousAs given in this study (human).

    Source sentences

    Summary
    in the first hour a slight arousing effect was indicated.
    1 context sentence
    Summary · context
    The effects of acute intravenous administration of synthetic DSIP, 25 nmoles/kg b.wt, on disturbed human sleep were tested in 6 middle-aged chronic insomniacs.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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