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Study · Animal study (in vivo) · rat · 1985

3 results

Delta-sleep-inducing peptide and two of its analogs reduce nocturnal increase of N-acetyltransferase activity in rat pineal gland.

Graf MV, Kastin AJ, Schoenenberger GA

Journal of neurochemistry1 Feb 1985Cited by 14 (Europe PMC)

PMID3838100 (opens in a new tab)DOI10.1111/j.1471-4159.1985.tb05458.x (opens in a new tab)PepBankPUB-03838100
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats, intravenous DSIP or either of two analogs given in the evening significantly reduced the nocturnal increase of pineal N-acetyltransferase 4 h later.

    In plain wordsIn rats, DSIP or two analogs given in the evening reduced the night-time rise of a pineal enzyme.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseNocturnal increase of pineal N-acetyltransferase after evening injection
    Study

    ratn: not reported in source

    Outcome group
    Sleep · Nervous system and cognition
    Studied dose
    Dose not stated · intravenousAs given in this study (rat).

    Source sentences

    Summary
    Intravenous injection of this peptide or either of two of its analogs in the evening significantly reduced the increase of N-acetyltransferase 4 h later.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats, the dose-response of the peptides on pineal N-acetyltransferase was inverted U-shaped, with the active dose about 30 nmol/kg.

    In plain wordsIn rats, the peptides worked best at a middle dose, about 30 nmol/kg, and less at lower or higher doses.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    MixedPineal N-acetyltransferase dose-response
    Study

    ratn: not reported in source

    Outcome group
    Sleep · Nervous system and cognition
    Studied dose
    about 30 nmol/kg · intravenousAs given in this study (rat).

    Measurements

    Active dose
    ≈ 30 nmol/kg
    pineal N-acetyltransferase

    Source sentences

    Summary
    The dose-response relationship of the peptides showed an inverted U-shaped pattern with the active dose about 30 nmol/kg.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats, morning injections of the peptides did not change pineal N-acetyltransferase activity.

    In plain wordsIn rats, injections in the morning did not change the pineal enzyme activity.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changePineal N-acetyltransferase after morning injection
    Study

    ratn: not reported in source

    Outcome group
    Sleep · Nervous system and cognition
    Studied dose
    Dose not stated · intravenousAs given in this study (rat).

    Source sentences

    Summary
    The effect appears to be dependent on the time of day of administration, as injections in the morning did not change the enzymatic activity.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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