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Study · Animal study (in vivo) · rat · 1985

2 results

Delta-sleep-inducing peptide reduces CRF-induced corticosterone release.

Graf MV, Kastin AJ, Coy DH, Fischman AJ

Neuroendocrinology1 Oct 1985Cited by 22 (Europe PMC)

PMID2995861 (opens in a new tab)DOI10.1159/000124200 (opens in a new tab)PepBankPUB-02995861
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats treated with chlorpromazine-morphine-pentobarbital, intravenous DSIP reduced corticosterone release stimulated by corticotropin releasing factor.

    In plain wordsIn rats, DSIP given into a vein lowered the corticosterone rise caused by CRF.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseCRF-stimulated corticosterone release
    Study

    ratn: not reported in source

    Outcome group
    Hormone levels · Endocrine and hormones
    Studied dose
    5-30 micrograms/kg · intravenousAs given in this study (rat).

    Source sentences

    Summary
    Significant reduction of corticosterone levels were observed after intravenous injection of 5-30 micrograms/kg DSIP.
    1 context sentence
    Summary · context
    We studied the effects of this nonapeptide on corticotropin releasing factor (CRF)-stimulated release of corticosterone in rats treated with chlorpromazine-morphine-pentobarbital.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats, DSIP had no effect on corticosterone release elicited by adrenocorticotropic hormone.

    In plain wordsIn rats, DSIP did not change the corticosterone rise caused by ACTH.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeACTH-stimulated corticosterone release
    Study

    ratn: not reported in source

    Outcome group
    Hormone levels · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    No effect of DSIP was found on the corticosterone release elicited by injection of adrenocorticotropic hormone.
    1 context sentence
    Summary · context
    We studied the effects of this nonapeptide on corticotropin releasing factor (CRF)-stimulated release of corticosterone in rats treated with chlorpromazine-morphine-pentobarbital.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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