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Study · Randomized controlled trial · n = 8 · 1994

6 results

Different effects of delta-sleep-inducing peptide on arginine-vasopressin and ACTH secretion in normal men.

Chiodera P, Volpi R, Capretti L, Giacalone G, Caffarri G, Davoli C, Nigro E, Coiro V

Hormone research1 Jan 1994Cited by 8 (Europe PMC)

PMID7698722 (opens in a new tab)DOI10.1159/000184207 (opens in a new tab)PepBankPUB-07698722
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. 6 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In normal men, DSIP infusion did not change basal circulating arginine-vasopressin concentrations.

    In plain wordsIn healthy men, DSIP did not change the body's own vasopressin levels compared with saline.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeBasal circulating AVP
    Study

    n = 8

    Comparator
    Placebo (normal saline)
    Outcome group
    Pituitary hormones · Endocrine and hormones
    Studied dose
    25 nmol/kg · infusion · 10-min infusionAs given in this study (human).

    Source sentences

    Summary
    The administration of DSIP or normal saline alone did not change the concentrations of circulating AVP.
    2 context sentences
    Summary · context
    DSIP (25 nmol/kg) was infused in 10 min to 8 normal men
    Summary · context
    In different occasions, a 10-min infusion of normal saline (placebo) was given instead of DSIP.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In normal men, DSIP infusion significantly decreased ACTH levels, beyond the slight decline seen with saline.

    In plain wordsIn healthy men, DSIP lowered ACTH levels more than the slight decline seen with saline.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseACTH levels
    Study

    n = 8

    Comparator
    Placebo (normal saline)
    Outcome group
    Pituitary hormones · Endocrine and hormones
    Studied dose
    25 nmol/kg · infusion · 10-min infusionAs given in this study (human).

    Source sentences

    Summary
    A slight physiological decline in ACTH levels was observed during saline infusion, whereas a significant decrease in ACTH levels was induced by DSIP administration.
    2 context sentences
    Summary · context
    DSIP (25 nmol/kg) was infused in 10 min to 8 normal men
    Summary · context
    In different occasions, a 10-min infusion of normal saline (placebo) was given instead of DSIP.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In normal men, DSIP did not modify the rise in plasma AVP induced by hypertonic saline.

    In plain wordsIn healthy men, DSIP did not change the vasopressin rise caused by salt-water stimulation.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeAVP response to osmotic stimulation
    Study

    n = 8

    Comparator
    Placebo (normal saline)
    Outcome group
    Pituitary hormones · Endocrine and hormones
    Studied dose
    25 nmol/kg · infusion · 10-min infusionAs given in this study (human).

    Source sentences

    Summary
    Osmotic stimulation of AVP secretion by hypertonic NaCl induced a significant increase in plasma AVP concentrations which was not modified by DSIP administration.
    2 context sentences
    Summary · context
    DSIP (25 nmol/kg) was infused in 10 min to 8 normal men
    Summary · context
    In different occasions, a 10-min infusion of normal saline (placebo) was given instead of DSIP.
  4. 04HumanRandomized controlled trialEfficacy outcome

    In normal men, ACTH secretory patterns during hypertonic saline with DSIP were similar to those during normal saline with DSIP.

    In plain wordsIn healthy men, ACTH patterns during salt-water stimulation with DSIP matched those with normal saline and DSIP.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeACTH secretory pattern during osmotic stimulation
    Study

    n = 8

    Comparator
    Placebo (normal saline)
    Outcome group
    Pituitary hormones · Endocrine and hormones
    Studied dose
    25 nmol/kg · infusion · 10-min infusionAs given in this study (human).

    Source sentences

    Summary
    The ACTH secretory patterns during hypertonic NaCl and hypertonic NaCl plus DSIP were similar to those observed during normal saline and normal saline plus DSIP, respectively.
    2 context sentences
    Summary · context
    DSIP (25 nmol/kg) was infused in 10 min to 8 normal men
    Summary · context
    In different occasions, a 10-min infusion of normal saline (placebo) was given instead of DSIP.
  5. 05HumanRandomized controlled trialEfficacy outcome

    In normal men, the orthostatic test gave similar plasma AVP increments regardless of earlier DSIP treatment.

    In plain wordsIn healthy men, standing upright raised vasopressin by a similar amount whether or not they had received DSIP.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeAVP response to orthostatic test
    Study

    n = 8

    Comparator
    Placebo (normal saline)
    Outcome group
    Pituitary hormones · Endocrine and hormones
    Studied dose
    25 nmol/kg · infusion · 10-min infusionAs given in this study (human).

    Source sentences

    Summary
    The orthostatic test provided similar plasma AVP increments, regardless of the previous treatment with DSIP
    2 context sentences
    Summary · context
    DSIP (25 nmol/kg) was infused in 10 min to 8 normal men
    Summary · context
    In different occasions, a 10-min infusion of normal saline (placebo) was given instead of DSIP.
  6. 06HumanRandomized controlled trialEfficacy outcome

    In normal men, results after DSIP given at time 0 and at -60 min were similar.

    In plain wordsIn healthy men, results were similar whether DSIP was given right before the test or 60 minutes earlier.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeEffect of DSIP timing (time 0 versus -60 min)
    Study

    n: not reported in source

    Comparator
    DSIP given at -60 min
    Outcome group
    Pituitary hormones · Endocrine and hormones
    Studied dose
    25 nmol/kg · infusion · 10-min infusionAs given in this study (human).

    Source sentences

    Summary
    The results obtained after the administration of DSIP at time 0 and at -60 min were similar.
    2 context sentences
    Summary · context
    In an additional 7 subjects, DSIP or placebo was given 60 min before hypertonic saline or the orthostatic test.
    Summary · context
    In different occasions, a 10-min infusion of normal saline (placebo) was given instead of DSIP.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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