The circadian cycle effects of DSIP on colonic temperature, blood pressure, and heart rate in control and area postrema-lesioned rats.

Yehuda S, Caspy T, Carasso RL

The International journal of neuroscience1 Oct 1988Cited by 7 (Europe PMC)

PMID3209378DOI10.3109/00207458808991600PepBankPUB-03209378

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In control rats, DSIP induced a shift in the hyperthermic cycle of colonic temperature.
In plain wordsIn rats, DSIP shifted the daily cycle of raised body temperature.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
MixedCircadian colonic temperature cycle in control rats
Study
ratn: not reported in source
Comparator
Saline
Outcome group
Body temperature · Whole body
Studied dose
0.1 mg/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
DSIP induced a shift in the hyperthermic cycle of control rats
1 context sentence(design, population, supporting numbers)
Summary · context
Groups of control and Area Postrema rats were treated with 0.1 mg/kg, i.p., DSIP or with saline, at 06:00, 09:00, 12:00, 15:00, 18:00, 21:00, 24:00, and at 03:00. Colonic temperature, blood pressure, and heart rate were measured 30 min after treatment.
Report a problemFND-0320937801
02AnimalAnimal study (in vivo)Efficacy outcome
In area postrema-lesioned rats, DSIP did not modify the noncyclic hypothermia.
In plain wordsIn rats with a lesion in the area postrema, DSIP did not change their low body temperature.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
No significant changeColonic temperature in area postrema-lesioned rats
Study
ratn: not reported in source
Comparator
Saline
Outcome group
Body temperature · Whole body
Studied dose
0.1 mg/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
but was unable to modify the noncyclic hypothermia found among Area Postrema-lesioned rats.
1 context sentence(design, population, supporting numbers)
Summary · context
Groups of control and Area Postrema rats were treated with 0.1 mg/kg, i.p., DSIP or with saline, at 06:00, 09:00, 12:00, 15:00, 18:00, 21:00, 24:00, and at 03:00. Colonic temperature, blood pressure, and heart rate were measured 30 min after treatment.
Report a problemFND-0320937802
03AnimalAnimal study (in vivo)Efficacy outcome
In control rats, DSIP decreased blood pressure.
In plain wordsIn rats, DSIP lowered blood pressure.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
DecreaseBlood pressure in control rats
Study
ratn: not reported in source
Comparator
Saline
Outcome group
Blood pressure · Cardiovascular
Studied dose
0.1 mg/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
Furthermore, DSIP caused a decrease in the blood pressure level of control rats
1 context sentence(design, population, supporting numbers)
Summary · context
Groups of control and Area Postrema rats were treated with 0.1 mg/kg, i.p., DSIP or with saline, at 06:00, 09:00, 12:00, 15:00, 18:00, 21:00, 24:00, and at 03:00. Colonic temperature, blood pressure, and heart rate were measured 30 min after treatment.
Report a problemFND-0320937803
04AnimalAnimal study (in vivo)Efficacy outcome
In area postrema-lesioned rats, DSIP had no effect on the already depressed blood pressure.
In plain wordsIn rats with a lesion in the area postrema, DSIP did not change their already low blood pressure.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
No significant changeBlood pressure in area postrema-lesioned rats
Study
ratn: not reported in source
Comparator
Saline
Outcome group
Blood pressure · Cardiovascular
Studied dose
0.1 mg/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
but had no such effect on the already depressed level of blood pressure in the Area Postrema-lesioned rats.
1 context sentence(design, population, supporting numbers)
Summary · context
Groups of control and Area Postrema rats were treated with 0.1 mg/kg, i.p., DSIP or with saline, at 06:00, 09:00, 12:00, 15:00, 18:00, 21:00, 24:00, and at 03:00. Colonic temperature, blood pressure, and heart rate were measured 30 min after treatment.
Report a problemFND-0320937804
05AnimalAnimal study (in vivo)Efficacy outcome
In control rats, DSIP decreased heart rate.
In plain wordsIn rats, DSIP slowed the heart rate.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
DecreaseHeart rate in control rats
Study
ratn: not reported in source
Comparator
Saline
Outcome group
Heart function · Cardiovascular
Studied dose
0.1 mg/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
Finally, DSIP decreased the heart rate of control rats
1 context sentence(design, population, supporting numbers)
Summary · context
Groups of control and Area Postrema rats were treated with 0.1 mg/kg, i.p., DSIP or with saline, at 06:00, 09:00, 12:00, 15:00, 18:00, 21:00, 24:00, and at 03:00. Colonic temperature, blood pressure, and heart rate were measured 30 min after treatment.
Report a problemFND-0320937805
06AnimalAnimal study (in vivo)Efficacy outcome
In area postrema-lesioned rats, DSIP significantly antagonized the elevated heart rate.
In plain wordsIn rats with a lesion in the area postrema, DSIP lowered their raised heart rate.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
DecreaseElevated heart rate in area postrema-lesioned rats
Study
ratn: not reported in source
Comparator
Saline
Outcome group
Heart function · Cardiovascular
Studied dose
0.1 mg/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
and significantly antagonized the elevated heart rate observed in the Area Postrema-lesioned rats.
1 context sentence(design, population, supporting numbers)
Summary · context
Groups of control and Area Postrema rats were treated with 0.1 mg/kg, i.p., DSIP or with saline, at 06:00, 09:00, 12:00, 15:00, 18:00, 21:00, 24:00, and at 03:00. Colonic temperature, blood pressure, and heart rate were measured 30 min after treatment.
Report a problemFND-0320937806

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 09:43 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

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